Bölüm "Tıbbi Farmakoloji" için listeleme
Toplam kayıt 45, listelenen: 1-20
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5-Hydroxytryptamine Does Not Reduce Sympathetic Nerve Activity or Neuroeffector Function In The Splanchnic Circulation
(Elsevier Science Bv, 2015)Infusion of 5-hydroxytryptamine (5 HI) in conscious rats results in a sustained (up to 30 days) fall in blood pressure. This is accompanied by an increase in splanchnic blood flow. Because the splanchnic circulation is ... -
Aging Changes Agonist Induced Contractile Responses In Permeabilized Rat Bladder
(Springer, 2015)Aging alters bladder functions where a decrease in filling, storage and emptying is observed. These changes cause urinary incontinence, especially in women. The aim of this study is to examine how aging affects the ... -
Agmatinin Deneysel Sıçan Septik Şok Modelinde Bozulmuş Vasküler Yanıta Etkisi
(Tıp Fakültesi, 2023)Sepsis is the inflammatory response of the host to pathogen. Regardless of the severity of inflammation, mortality is observed as a result of impaired hemodynamic homeostasis-mediated organ dysfunction. Therefore, treatment ... -
Alamandinin Lipopolisakkarit ile İndüklenmiş Sıçan Sepsis Modelinde Vasküler ve Renal Fonksiyonlara Etkisi
(Sağlık Bilimleri Enstitüsü, 2024)Sepsis is defined as uncontrolled inflammation leading to multiple organ system failure and dysfuncion. Acute kidney injury is an important cause of significant morbidity and mortality in sepsis. Alamandine (ALA) is a ... -
Alpha(1)-Adrenoceptor-Mediated Contraction Of Rat Aorta Is Partly Mediated Via Transactivation Of The Epidermal Growth Factor Receptor
(Wiley-Blackwell, 2010)Background and purpose: High level of plasma catecholamines is a risk factor for vascular diseases such as hypertension and atherosclerosis. Catecholamines induce hypertrophy of vascular smooth muscle through alpha(1)-ad ... -
Automated Discrimination of Psychotropic Drugs in Mice Via Computer Vision-Based Analysis
(Elsevier Science Bv, 2009)We developed an inexpensive computer vision-based method utilizing an algorithm which differentiates drug-induced behavioral alterations. The mice were observed in an open-field arena and their activity was recorded for ... -
Bernard Lerer: Recipient of the 2014 Inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association For Clinical Pharmacogenetics)
(Mary Ann Liebert, Inc, 2014)This article announces the recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine by the Pacific Rim Association for Clinical Pharmacogenetics (PRACP): Bernard ... -
Decreased Activity And Genetic Polymorphisms Of Cyp2C19 In Behcet'S Disease
(Wiley, 2017)Behcet's disease (BD) is a systemic autoimmune disorder. Cytochrome P450 enzymes (CYPs) are responsible for various drug metabolism reactions as well as those of endogenous substances which may be associated with autoimmune ... -
Electrophysiological Effects of Eslicarbazepine on Selected Nav1.6 Variants Associated with Developmental and Epileptic Encephalopathies
(Sağlık Bilimleri Enstitüsü, 2020)Major problems with the current anti-epileptic drugs (AED) are resistance, inability to modify the course of the disease and side effects profiles, which rises the need for improved AEDs for all age group of patients. ... -
Empaglı̇flozı̇nı̇n Sıçanda Lı̇popolı̇sakkarı̇t ile İndüklenmı̇ş Sepsı̇ste Akut Böbrek Hasarı Üzerı̇ne Etkı̇lerı̇nı̇n Değerlendı̇rı̇lmesı̇
(Sağlık Bilimleri Enstitüsü, 2022-12-26)Sepsis is a fatal disease that progresses with uncontrolled inflammation and acute septic renal injury and kidney failure are frequently observed in sepsis. Mortality is significantly higher in sepsis patients who ... -
Endotelin Reseptör Antagonisti Tezosentanın Sıçanda Lipopolisakkarit İle Oluşturulan Deneysel Sepsis Modelinde Kardiyak Disfonksiyon Üzerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2019)KARA, S.C., Effect of Endothelin Receptor Antagonist Tezosentan on Cardiac Dysfunction on an Experimental Model of Sepsis Induced by Lipopolysaccharide in Rats, Hacettepe University Graduate School of Health Sciences, ... -
Estrogen And Aging Affect Synaptic Distribution Of Phosphorylated Lim Kinase (Plimk) In Ca1 Region Of Female Rat Hippocampus
(Pergamon-Elsevier Science Ltd, 2008)17 beta-Estradiol (E) increases axospinous synapse density in the hippocampal CA1 region of young female rats, but not in aged rats. This may be linked to age-related alterations in signaling pathways activated by synaptic ... -
Evidence For Regulation Of Udp-Glucuronosyltransferase (Ugt) 1A1 Protein Expression And Activity Via Dna Methylation In Healthy Human Livers
(Wiley, 2013)Objectives Interindividual variability in glucuronidation of bilirubin and drugs by UDP-glucuronosyltransferase 1A1 (UGT1A1) is considerable and only partially explained by genetic polymorphisms and enzyme inducers. Here ... -
Farede Lipopolisakkarit ile Oluşturulan Deneysel Sepsis Modelinde Alfa-7 Nikotinik Reseptör Agonisti PNU-282987’nin, Mezenter-Portal Perfüzyon ve Organ Hasarına Etkileri
(Tıp Fakültesi, 2022)Sepsis is life-threatening organ dysfunction caused by dysregulated host response to infection. It is among the most common reasons for admission to intensive care units in worldwide. Sepsis is characterized by systemic ... -
Hepatitis A Immunity In Yozgat, Turkey
(2019)BACKGROUND Since routine immunization could change the epidemiological profile of hepatitis A virus (HAV) infection in the future, it is important to determine the baseline immunity to HAV across Turkey. OBJECTIVE The aim ...