Bölüm "Nörolojik ve Psikiyatrik Temel Bilimler" için listeleme
Toplam kayıt 38, listelenen: 1-20
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Alzheimer Hastalığında serum proteomik analizleri ile yeni biyobelirteçlerin araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024)Current diagnostic criteria set for Alzheimer’s Disease (AD) is not sufficient for accurate prediction of the pathology. The use of CSF and PET biomarkers increase the accuracy of diagnoses but they are limited for widespread ... -
Beyin Kökenli Nörotrofik Faktörün Kortikal Yayılan Depresyonun Tetiklediği Nöroinflamasyon Üzerine Etkilerinin Araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-04)Cortical spreading depression (CSD) is not just an experimental phenomenon, but also seen in the conditions such as migraine aura, ischemic stroke, acute brain trauma, intracranial hemorrhage and epilepsy in people. It has ... -
Bilateral Temporal Bone Xanthomas in Type II Hypercholesterolemia
(Turkish Neurosurgical Soc, 2010)We present a very rare case of intracranial xanthoma with bilateral temporal bone involvement. The lesion caused destruction and remodelling in mastoid air cells. On the right side, cerebellar compression was obvious. The ... -
Capillary Pericytes Express Α-Smooth Muscle Actin, Which Requires Prevention of Filamentous-Actin Depolymerization For Detection
(eLife Sciences, 2018)Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, ... -
Data Of Ascending Cortical Vein Occlusion Induced Spreading Depression
(Elsevier, 2018)The data presented in this article are related to the research article entitled “Microembolism of single cortical arterioles can induce spreading depression and ischemic injury; a potential trigger for migraine and related ... -
Default Mode Network Connectivity Is Linked to Cognitive Functioning and Csf A Beta(1-42) Levels In Alzheimer'S Disease
(Elsevier Ireland Ltd, 2016)Background: Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific A beta pathology. Methods: Cognitive profiles; DMN connectivity alterations; ... -
Deneysel İskemik İnme Modelinde Oksidatif Hasarın Hücresel Düzeyde İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-11)The aim of this study is direct intravital monitorization of the pharmacological effects of two well-known neuroprotectant antioxidant molecules having different blood-brain barrier (BBB) permeability against ischemia/reperfusion ... -
Dişi ve Erkek Farelerde Depresyonun Stres ve Optogenetik Modelinde MSS-Kökenli Nöroinflamasyonun İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022)There is ample evidence for the role of inflammatory signaling pathways in depression. However, in these studies, depression was modeled either by bacterial endotoxins or by acute stress, usually studied only in male animals ... -
DOPA Yanıtlı Distoni Fare Modelinde Striatal Kolinerjik Sistemin Rolü
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022-05-26)Dystonia, which is the third most common movement disorder, is a heterogeneous group of diseases both etiologically and pathophysiologically. Striatal cholinergic dysfunction is a common pathophysiologiccal mechanism ... -
Dysregulated Fibroblast Growth Factor (Fgf) Signaling in Neurological and Psychiatric Disorders
(Academic Press Ltd Elsevier Science Ltd, 2016)The role of the fibroblast growth factor (FGF) system in brain-related disorders has received considerable attention in recent years. To understand the role of this system in neurological and psychiatric disorders, it is ... -
Elektrokonvulzı̇f Nöbetlerı̇n Farelerde Nöroı̇nflamatuvar Yanıt Üzerı̇ndekı̇ Olası Etkı̇sı̇ ve Bu Etkı̇nı̇n Doğurduğu Sonuçların İncelenmesı̇
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2017)Neuroinflammation has been shown to be involved in pathological conditions like cortical spreading depression, seizures and ischemia. Its involvement in physiological processes like neurogenesis, learning and memory has ... -
Farede Optogenetik Yolla Tetiklenen Kortikal Yayılan Depresyonun Subkortikal Yayılım Mekanizmalarının İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019)Uzay B. Investigation of the Subcortical Spreading Mechanisms of the Optogenetically Induced Cortical Spreading Depression in Mice, Hacettepe University Graduate School of Health Sciences Basic Neurological Sciences ... -
Glikojenin İskemik İnme ve Retinal İskemi Üzerine Olan Etkilerinin Nörogliovasküler Seviyede İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020-01-16)Ischemic stroke results in sudden blood flow cessation thus leads to sudden onset unmet energy requirements. Although the clotted artery is recanalized and blood flow is restored back, brain perfusion may not be sustained ... -
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation And Provides Neuroprotection
(Lippincott Williams & Wilkins, 2018)Background and Purpose-Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized ... -
Inadequate Brain Glycogen Or Sleep Increases Spreading Depression Susceptibility
(Wiley, 2018)Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional ... -
Inhibiting 12/15-Lipoxygenase To Treat Acute Stroke In Permanent And Tpa Induced Thrombolysis Models
(Elsevier Science Bv, 2018)12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, ... -
Kortikal Yayılan Depresyonun Tetiklediği Nöroinflamasyonun Çözülmesi ve Bunun Migren Baş Ağrısı Patofizyolojisindeki Yeri
(Sağlık Bilimleri Enstitüsü, 2019-08-28)Migraine is a common disorder which manifests itself as severe headache. Migraine pathophysiology needs deeper understanding in order to develop more effective treatments. Cortical spreading depression (CSD) is the ... -
KORTİKAL YAYILAN DEPOLARİZASYON İLE TETİKLENEN NÖRO-PARAİNFLAMASYONDA NLRP2 İNFLAMAZOMUNUN ROLÜ
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024)Migraine is a common headache syndrome in the general population. Inflammation resulting from activation of the trigeminovascular system plays an important role in its pathophysiology. Cortical spreading depolarization ... -
Lipopolisakkaritle Oluşturulan Nöroinflamasyon Modelinde Pro-İnflamatuar Sitokinlerin ve Yolaklarının Glia Limitans Üzerine Etkileri
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-09-10)The term Neuroinflammation (NI) that is unique for Central Nervous System (CNS), defines a process that includes complex cellular and intercellular relationships. The inflammatory responses of microglia and astrocytes ... -
Mitochondrial Dna Analysis in The Turkish Leber'S Hereditary Optic Neuropathy Population
(Royal Coll Ophthalmologists, 2001)Purpose To define the prevalence of a panel of mitochondrial DNA (mtDNA) mutations associated with Leber's hereditary optic neuropathy (LHON) in the Turkish LHON population. LHON-associated mtDNA mutations have been found ...