Poli(Bütilenadipat-ko-Tereftalat) (PBAT) Mikro ve Nanopartiküller: Sentez, Karakterizasyon ve Kurkumin Salım Kinetiğinin İncelenmesi

Abstract

This study was performed with the support of ‘Poly(butylene adipate-coterephthalate) (PBAT) Micro and Nanoparticles: Synthesis, Characterization and Investigation of Curcumin Release Kinetics’ entitled and FHD-2016-11953 coded Hacettepe University funding project and TÜBİTAK 2210-C Primary Subject National Scholarship Program for MSc Students. In the scope of the thesis, the efficiency of aliphatic-aromatic copolyester poly(butylene adipate-co-terephthalate) (PBAT) in drug release applications was investigated. For this purpose, after the synthesis and characterization of PBAT micro and nanoparticles the loading and in-vitro release of curcumin that is recently prominent as a natural, anticancerogenic drug was achieved and the cytotoxic effect of the particles was determined in the cell culture systems.