The Spectrum Of Diseases Causing Fever Of Unknown Origin In Turkey: A Multicenter Study
Tarih
2008Yazar
Kucukardali, Yasar
Oncul, Oral
Cavuslu, Saban
Danaci, Mehmet
Calangu, Semra
Erdem, Hakan
Topcu, Ayse Wilike
Adibelli, Zuhal
Akova, Murat
Karaali, Emel Azak
Ozel, Ahmet Melih
Bolaman, Zahit
Caka, Bulent
Cetin, Birsen
Coban, Erkan
Karabay, Oguz
Karakoc, Cagla
Karan, Mehmet Akif
Korkmaz, Selda
Sahin, Gulsen Ozkaya
Pahsa, Alaaddin
Sirmatel, Fatma
Solmazgul, Emrullah
Ozmen, Namik
Tokatli, Ilyas
Uzun, Cengiz
Yakupoglu, Gulsen
Besirbellioglu, Bulent Ahmet
Gul, Hanefi Cem
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Objective: The purpose of this trial was to determine the spectrum of diseases with fever of unknown origin (FUO) in Turkey. Methods: A prospective multicenter study of 154 patients with FUO in twelve Turkish tertiarycare hospitals was conducted. Results: The mean age of the patients was 42 +/- 17 years (range 17-75). Fifty-three (34.4%) had infectious diseases (ID), 47 (30.5%) had non-infectious inflammatory diseases (NIID), 22 (14.3%) had malignant diseases (MD), and eight (5.2%) had miscellaneous diseases (Mi). In 24 (15.6%) of the cases, the reason for high fever could not be determined despite intensive efforts. The most common ID etiologies were tuberculosis (13.6%) and cytomegalovirus (CMV) infection (3.2%). Adult Still's disease was the most common NIID (13.6%) and hematological malignancy was the most common MD (7.8%). In patients with NIID, the mean duration of reaching a definite diagnosis (37 +/- 23 days) was significantly longer compared to the patients with ID (25 +/- 12 days) (p = 0.007). In patients with MD, the mean duration of fever (51 +/- 35 days) was longer compared to patients with ID (37 +/- 38 days) (p = 0.052). Conclusions: Although infection remains the most common cause of FUO, with the highest percentage for tuberculosis, non-infectious etiologies seem to have increased when compared with previous studies. (C) 2007 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.