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BORTEZOMİB VE İMATİNİB'İN PANKREAS KANSERİNDE OLASI SİNERJİSTİK ETKİSİNİN İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2023-05-22)The high mortality rate among pancreatic cancer patients underlines the importance of proper treatment. However, the traditional treatment strategies remain inadequate indicating that alternative therapy options need to ... -
Akciğer Kanseri ve Sol Meme Radyoterapisinde Kardiyak Altyapı Marjlarının Oluşturulması ve Tedavi Planı Optimizasyonu
(Kanser Enstitüsü, 2023)In thoracic irradiations, the coronary arteries (CA) are involuntarily exposed to radiation and subsequent cardiovascular toxicities may occur. To avoid this, the importance of accurately creating the safety margins (SM) ... -
MEME KANSERİNDE, IL-1β İLE TETİKLENEN EPİTELYAL MEZENKİMAL DÖNÜŞÜMDE HÜCRE İSKELETİ DİNAMİKLERİNİN İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2023-03)The presence of interleukin (IL)-1β, a proinflammatory cytokine, has been demonstrated in the breast cancer microenvironment. IL-1β supports cell survival, proliferation, adhesion, invasion, and migration mechanisms. It ... -
Prostat Ve Akciğer Kanserlerinin Vmat (Volümetrik Ayarlı Radyoterapi) ve Yart (Yoğunluk Ayarlı Radyoterapi) Tabanlı Tedavilerinde Termal Fotonötron Kontaminasyonunun İncelenmesi
(Kanser Enstitüsü, 2022)Yılmaz, E. Investigation of Thermal Photoneutron Contamination in VMAT (Volumetric Modulated Arc Therapy) and IMRT (Intensity-Modulated Radiation Therapy)-Based Treatments of Prostate and Lung Cancers, Hacettepe University ... -
Functions of the Activation Induced Cytidine Deaminase (AID) and Toll-like Receptors (TLR) on Regulation of the Central B cell Tolerance Checkpoint
(Sağlık Bilimleri Enstitüsü, 2022-09)Çakan, E., Functions of the Activation Induced Cytidine Deaminase (AID) and Toll-Like Receptors (TLR) on Regulation of the Central B Cell Tolerance Checkpoint, Hacettepe University Graduate School Health Sciences Program ... -
Comparatıve Analysıs of Myeloıd-Derıved Suppressor Cells From Blood and Spleen in Gastrıc and Pancreatıc Cancer
(Sağlık Bilimleri Enstitüsü, 2022-07-29)Under physiological conditions, development and maturation of the myeloid cells take place in the bone marrow. In case of chronic inflammatory disorders such as cancer, production of chemokines, growth factors, and cytokines ... -
Pankreas Kanseri Hücre Hattında TFAM Ekspresyon Düzeyinin Hücre Fonksiyonları Üzerine Etkisi
(Kanser Enstitüsü, 2022-07-29)Pancreatic cancer is an aggressive malignancy with a poor prognosis. Early diagnosis and application of tumor-specific treatment are very important in pancreatic cancer. Therefore, new biomarkers are needed in the diagnosis ... -
Tip-1 Yardımcı T (Th1) Hücrelerin Radyasyon Stresi Altında Fonksiyonel ve Fenotipik Değişimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022-07-18)It's critical to understand changes in the functional and phenotypic status of T cells, which play a key role in the anti-tumor response due to the immunosuppressive environment in the tumor microenvironment. In chronic ... -
Hacettepe Üniversitesi Onkoloji Hastanesinde Yatmakta Olan Hastalara Bakım Verenlerin Sosyodemografik Özelliklerinin ve Yaşam Kalitelerinin, Hastaların Yaşam Kalitesi Üzerine Etkisi
(Kanser Enstitüsü, 2022)Güner Üliç. P., The Effects of Sociodemographic Characteristics and Quality Of Life of Caregivers on Quality of Life of Inpatient Cancer Patients in Hacettepe University Oncology Hospital, Hacettepe University Graduate ... -
İnsan Makrofajlarında Nitrik Oksit Sentaz 2 (Nos2) İfade ve Aktivitesinin Bazal Benzeri Meme Kanseri Hücrelerinden Üretilen Faktörler Varlığında İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022)Macrophages are the leading cells of innate immunity in the immune response against pathogens and are involved in the regulation of adaptive immune responses. Macrophages with microbicidal properties promote the proinflammatory ... -
Akciğer Kanser Hücrelerinden Salınan Eksozomların Makrofaj Polarizasyonuna ve Fonksiyonlarına Etkisinin Araştırılması
(Kanser Enstitüsü, 2021)Lung cancer has the highest mortality rate in both men and women worldwide. With our developing technology and knowledge, the research of methods in cancer targeted treatments have turned to target such as tumor microenvironment, ... -
The Role of Regnase-1 Protein in Sculpting of Tumor Microenvironment
(Kanser Enstitüsü, 2021)The tumor microenvironment (TME) contains cancer-associated fibroblasts (CAFs) and their tumor-supportive role helps to build an environment in favor of cancer cell progression. Recent researches have revealed that targeting ... -
HER2 EKSPRESYONU OLAN MEME KANSERİ HÜCRELERİNDE ÖKARYOTİK ELONGASYON FAKTÖR-2 KİNAZ (eEF2K) AKTİVASYONUNUN ROLÜ
(Kanser Enstitüsü, 2021-06-22)Continuous activation of HER2 leads to the deregulation of various biological responses such as cell proliferation, survival, and migration, and tumor growth. eEF2K is a protein kinase involved in the regulation of protein ... -
Hipoksinin Anti-Tümor İmmün Yanıt Üzerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)Inhibition of tumor angiogenesis has been extensively utilized in the treatment of metastatic colorectal cancer and renal cell carcinoma. Complete disruption of tumor angiogenesis results in hypoxia which promotes tumor ... -
Β-Catenın N-Terminal Bölge Değişikliklerinin Neoplastik Süreçlerdeki Rolünün Araştırılması
(Kanser Enstitüsü, 2021)Uzun, S, Investigation of The Role of β-catenin N-terminal Domain Alterations in Neoplastic Processes, Hacettepe University Graduate School of Health Sciences Tumor Biology and Immunology Program Doctor of Philosophy ... -
Tüm Beden Işınlamalarında Farklı Tedavi Planlama Tekniklerinin Dozimetrik Olarak Karşılaştırılması
(Kanser Enstitüsü, 2021-02-10)The purpose of Total Body Irradiation (TBI) in radiotherapy is to suppress the immune system of the patient by destroying bone marrow cells, prepare the host for bone marrow transplantation and enhance the antitumor effect. ... -
Stereotaktik Radyocerrahi ve Stereotaktik Beden Radyoterapisi Uygulamalarında Manyetik Rezonans Görüntüleme Tabanlı Tedavi Planlama Sisteminin Kullanılabilirliği
(Kanser Enstitüsü, 2021-02-05)In this study, feasibility of Magnetic Resonance Imaging (MRI) based treatment planning system instead of computed tomography (CT) in SRC and SBRT was evaluated. Three different scenarios were created for density and ... -
Cyberknife® ve Varian RapidArc® TrilogyTM Cihazında Üç Boyutlu Uzaysal Fraksiyone Grid Terapi Doz Karakteristiklerinin Karşılaştırılması
(Kanser Enstitüsü, 2020-12). Lattice therapy is an innovative method to increase the effectiveness of radiotherapy by delivering a high dose to the target volume irradiated through small spaces in one or more fractions.In this study, we investigated ... -
Mikrotübül İnhibitörlerinin Kanser Hücrelerinde Tehlike-İlişkili Moleküler Desen Düzeylerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Cancer cells are proliferate rapidly and uncontrolled. Chemotherapeutics such as vinorelbine and colchicine affect the cell cycle and DNA synthesis mechanism; they causes cells to be kept in the G2 / M phase by preventing ... -
Pankreas Kanserinde MUC1, MUC4, MUC16 Molekülleri ile Treg Hücreleri ve Epitelyal-Mezenkimal Transizyon Arasındaki İlişki
(Kanser Enstitüsü, 2020-08-14)Pancreatic cancer has a poor prognosis due to its increased invasion and metastasis capacity. Transmembrane mucins normally have as their functions to protect the epithelial tissues but their expression level is has been ...
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