Browsing Kanser Enstitüsü Tez Koleksiyonu by Issue Date
Now showing items 21-40 of 67
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Cyberknife Synchrony® Solunum Takip Sisteminin Polimer Jel Dozimetre ile Üç Boyutlu Performans Analizi
(Kanser Enstitüsü, 2017-02-20)ŞAHİN, M. C. Three Dimensional Performance Analysis Of Cyberknife Synchrony® Respiratory Tracking System Using Polymer Gel Dosimeter. Hacettepe University Institute of Health Sciences, Thesis in Radiotherapy Physics ... -
Cyberknife® X-Sight® Vertebra Takip Sisteminin Vertebra Dışı Lezyonlarda Uygulanabilirliğinin Araştırılması
(Kanser Enstitüsü, 2017-03-25)One of devices which uses the ablative dose for the Stereotactik body radiation theraphy (SBRT) is CyberKnife® Stereotactic Radiosurgery System. This device, has different tracking system from other devices. This systems ... -
Modulation of Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR)-GITR Ligand (GITRL) Interaction in Breast Cancer Cells Under the Control of Ataxia Telangiectasia Mutated (ATM) Promoter
(Kanser Enstitüsü, 2017-07-21)Treatment response for basal-like breast cancers (BLBC) is limited and this aggressive breast cancer sub-type has poor prognosis and high mortality. Our first aim is to investigate ATM activity in BLBC cell lines with ... -
The Effect of Acute Myeloid Leukemia Cells Expressing PD-L2 Co-Stimulatory Molecule on Helper T Cell Activation
(Sağlık Bilimleri Enstitüsü, 2017-07-25)The binding of PD-1 to its ligands (PD-L1 and PD-L2) inhibits and/or regulates T cell responses. Myeloid leukemia cells can express both co-activatory and co-inhibitory molecules simultaneously. The function of PD-L1 in ... -
3′End Maturation of Human Telomerase Rna Component (Terc) and Its Effects on Telomere Dynamics
(Sağlık Bilimleri Enstitüsü, 2017-09-15)Telomerase RNA Component (TERC) is the non-coding RNA template and scaffold of the telomerase holoenzyme. TERC level has been shown to be a limiting factor for telomerase activity, lower levels resulting in telomere diseases ... -
Mikozis Fungoides Mikroçevresinde Bulunan Dermal Fibroblastların Anti-Tümör İmmün Yanıta Etkisi
(Sağlık Bilimleri Enstitüsü, 2017-12)Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. The interaction of the neoplastic lymphocytes with their microenvironment is of crucial importance in disease progression. Cancer associated ... -
Meme Kanserinde, Normal Fibroblastlar ve Kanserle İlişkili Fibroblastların Monosit Çağrılması, Makrofaj Polarizasyonu ve İnvazyona Etkisi
(Kanser Enstitüsü, 2018)GÖK YAVUZ B., The Effect of Cancer Associated Fibroblasts and Normal Fibroblasts on Monocyte Recruitment, Macrophage Polarization and Invasion in Breast Cancer. Hacettepe University Institute of Health Sciences Ph.D Thesis ... -
CyberKnife® Robotik Radyocerrahi Cihazında MAGIC Polimer Jel Dozimetre İle Küçük Alan Dozimetrisinin İncelenmesi
(Kanser Enstitüsü, 2018)ENKAVİ, M.F. Investigation of Small Field Dosimetry with MAGIC Polymer Gel Dosimeter in CyberKnife® Robotic Radiosurgery Device. Hacettepe University Institute of Health Sciences, MSc. Thesis in Radiotherapy Physics Program, ... -
Kanser Tanısı Alan Hastaların Birinci Derece Yakınlarında Sigara Bırakma Davranışının Değerlendirilmesi
(Kanser Enstitüsü, 2018)Tobacco use is one of the most important causes of morbidity and mortality. As a consequence, quitting smoking is a fundamental aim of primary prevention of diseases. Diagnosing a smoker or his/her relative with cancer may ... -
Investigation of Lung Cancer Cell Culture Supernatants Activated with Tlr Agonists Effect on Macrophage Polarization
(Kanser Enstitüsü, 2018)It is well known that inflammation is involved in the development of lung cancer. Macrophages in the tumor microenvironment are the anti-inflammatory M2 type and anti-tumor type M1. Inflammatory cytokines, such as IL-1β, ... -
Küçük Hücreli Dışı Akciğer Kanserinde Serum ve Glukokortikoid ile İndüklenebilen Kinaz 1 (SGK-1) İnhibisyonunun Epidermal Büyüme Faktörü Reseptörü (EGFR) Aracılı Sinyal Yolağı Üzerindeki Etkisi
(Kanser Enstitüsü, 2018)Oncogenic activation of epidermal growth factor receptor (EGFR) signaling exists in non-small cell lung cancer (NSCLC). Increased expression of Serum and Glucocorticoid Inducible Kinase 1 (SGK-1) in NSCLC cells was found ... -
Evaluation of Metadherin Expression in Breast Cancer
(Sağlık Bilimleri Enstitüsü, 2018)Metadherin gene (MTDH/ AEG-1/ Lyric) encodes a 582- aminoacid protein, metadherin (MTDH), which is almost undetectable by immunohistochemistry in normal breast tissue. MTDH expression is markedly increased in breast cancer ... -
Vajinal Kaf Brakiterapi Uygulamaları için Yoğunluk Ayarlı Aplikatör Tasarımı: Dozimetrik Fizibilite Çalışması
(Kanser Enstitüsü, 2018)Depending on technological advances in radiotherapy, the use of three-dimensional (3D) treatment planning in brachytherapy (BRT) applications has provided a great advantage in terms of efficacy of treatment in gynecological ... -
Effect of Calcıum Carbonate Encapsulatıon on the Oral Actıvıty of Cpg Olıgodeoxynucleotıdes and Assessment of the Response of Human Monocytes to Tlr Lıgands
(Sağlık Bilimleri Enstitüsü, 2018-03)Toll-like receptor (TLR) ligands modulate immune responses and have been used in immunotherapy. Clinical trials designed to evaluate the utility of CpG ODN, a synthetic TLR9 ligand, relied on parenteral routes of administration. ... -
Inhibition of Serum and Glucocortıcoıd Inducible Kinase 1 (Sgk1) in Triple Negative Breast Cancer
(Kanser Enstitüsü, 2018-07-18)Glucocorticoid receptor overexpression leads to poor prognosis in breast cancer, particularly in triple negative phenotype. This poor prognosis has been shown to be due to the activation of SGK1 (serum and glucocorticoid ... -
Kolorektal Kanserlerde Th17 İlişkili IL-17, IL-21 ve IL-22 Sitokinlerinin Ekspresyon Düzeylerinin Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2019)Immune system cells and released cytokines in tumor microenvironment have a very important role in cancer prognosis. Also, T-helper 17 (Th17) cells have been frequently found in many tumors microenvironment and their effects ... -
Evaluation of T Cell Responses In The Co-Cultures Establıshed Wıth Neutrophıls, Monocytes, and Lung Adenocarcınoma Cells
(Kanser Enstitüsü, 2019)CD4+ and CD8+ T cells are critical mediators in anti-tumor immunity. Together with neutrophils, they have been shown to dominate the immune landscape of the non-small cell lung cancer (NSCLC). A number of studies have ... -
Prostat Kanserinde Tlr Agonistlerinin M1, M2 Makrofaj Polarizasyonunda Rolü
(Kanser Enstitüsü, 2019)It is well known that inflammation is effective in the development of prostate cancer. Macrophages in the tumor microenvironment are either anti-inflammatory M2-type that help tumor growth or pro-inflammatory M1-type that ... -
Meme Kanseri Hücreleri Tarafından Üretilen Fibronektinin Miyeloid Hücre Karakteri Üzerine Etkisi
(Kanser Enstitüsü, 2019)Basal-like breast cancer (BLBC) possess high capacity to regulate inflammation and identified with high-level myeloid cell infiltration. Extracellular matrix components produced by tumor cells, e.g. fibronectin (FN), can ... -
Cxcl Kemokı̇n ÖncüL Dı̇zelerı̇nden Türevlenen Küçük Peptı̇t MoleküLlerı̇nin İmmün Düzenleyı̇cı̇ Etkı̇sinin Değerlendirmesı̇
(Kanser Enstitüsü, 2019-03-12)Peptide structured small molecules function in the regulation of a variety of physiological processes and intercellular communication. In this study, precursor sequences of known 17 CXCL chemokine molecules were analyzed ...
