Browsing Temel Tıp Bilimleri Bölümü Tez Koleksiyonu by Funding "Bilimsel Araştırma Projeleri KB"
Now showing items 1-20 of 48
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AEBP1/ACLP'nin Protein Etklileşim Ağının Proteomik ve Biyoinformatik Yöntemlerle Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Extracellular Matrix (ECM) is the mechanical supportive structure for cells and tissues. Chronic damage may cause loss of ECM integrity that may result in fibrosis which is the progressive and irreversible accumulation of ... -
Ailevi Akdeniz Ateşi Hastalarında Otoenflamasyonun İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease. The aim of this study is to determine the changes of GSDMD, IL-1B, and IL-18 in disease attacks of FMF and to compare their levels in the ... -
Allojenik Mezenkimal Kök Hücre Eksozomlarının Üç Boyutlu Mikroakışkan Proksimal Tübül Platformundaki İskemik Akut Böbrek Hasarında Terapötik Etkilerinin Değerlendirilmesi
(Tıp Fakültesi, 2022-05)Cam SB, The Assessment Of The Therapeutic Effects of Allogeneic Human Mesenchymal Stem Cell Exosomes on Ischemic Acute Kidney Injury Model Constituting Three Dimensional Microfluidic Proximal Tubule-On-A-Chip Platform, ... -
Antioksidan Kullanımının Meme Kanseri Tedavisi Üzerindeki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021-01-20)Drug resistance against chemotherapy is one of the main factors limitating the success of cancer treatment. Several studies have reported that the expression level of the glutathione S-transferase P1 (GSTP1) isozyme from ... -
Bisfenol A’nın Hepg2 Hücrelerine Olan Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2020)Öz, E. Examination of the Effects of Bisphenol A on HepG2 Cells. Hacettepe University Graduate School of Health Sciences, Biochemistry Program, Master Thesis, Ankara, 2020. In this study, it was aimed to determine the ... -
Büyüme Çağındaki Sıçanlarda Oral Kaprilik Asit Uygulamasının Açil Ghrelin ve Büyüme Hormonu Düzeyleri ile Anksiyete Üzerine Etkisi
(Tıp Fakültesi, 2022)Caprylic acid is a medium chain fatty acid containing 8 carbons. Caprylic acid is necessary for the conversion of ghrelin which is known as the hunger hormone, to its active form acyl ghrelin. In addition to its functions ... -
Deneysel Parkinson Hastalığı Modelinde Obezitenin Motor Becerilere Etkisi ve Beyin Tirozin Hidroksilaz Düzeyi, Dopaminerjik Reseptörler ve Leptin Reseptörleri ile İlişkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023-03)Excessive increase in body weight, which has already become a public health problem, is also associated with many diseases. On the other hand, prolonged life expectancy also increases the incidence of neurodegenerative ... -
Desma Mutant Zebra Balığı Modelinde Tedavi Amaçlı Xmu-Mp-1 Uygulaması
(Sağlık Bilimleri Enstitüsü, 2021)In this thesis, the application of XMU-MP-1 drug candidate molecule which is a MST1 / 2 kinase inhibitor and selectively inhibits the Hippo pathway was performed by mixing the drug with zebrafish embryo egg water or adult ... -
Determination of Lipid Metabolism Alterations and Their Association with Disease Pathogenesis in Sickle Cell Disease
(Sağlık Bilimleri Enstitüsü, 2020-07-07)Sickle cell disease (SCD) is a hemoglobinopathy that causes severe anemia and is characterized by lipid abnormalities, oxidative stress and chronic inflammation. It is caused by a single point-mutation in the beta globin ... -
Diyabet Hastalarında Mineral Trioksit Agregat/1α,25-Dihidroksivitamin D3 Kombinasyonu İle Dental Pulpa Kök Hücrelerinde Odontojenik Farklılaşmanın Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021-01-15)Dental treatments in diabetic patients have been reported to fail in the long term and these patients have more tooth extraction. It is aimed to investigate the odonto/osteogenic differentiation potential of the combination ... -
Farklı Dozlarda ve Sükrozla Birlikte Uygulanan Kakaonun (Theobroma Cacao) Sıçanlar Üzerindeki Anksiyolitik Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Anxiety disorder is a common condition. The effectiveness of current pharmacological treatments is delayed and their side effects negatively impact patients. Therefore, patients turn to different products. Cocoa is a ... -
Fenilketonüride Öğrenme Bellek Mekanizmasının Dişi Ve Erkek Sıçanlarda cAMP/PKA/CREB/BDNF Yolağı Üzerinden İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2020)Phenylketonuria is a rare hereditary metabolic disease characterized by deficiency of phenylalanine hydroxylase. The absence of enzyme causes blood phenylalanine levels to rise. If patients are not treated, irreversible ... -
FF-MAS Oksisterolünün Folikülogenezdeki Rolünün ve Hedgehog Sinyal Yolağıyla İlişkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2021-04-29)FF-MAS oxysterol is a derivative of steroid, found in follicular fluid and involved in oocyte maturation. Hedgehog pathway is one of the many cell signaling mechanisms effective in cell proliferation and its effect on the ... -
Hacettepe Üniversitesi Merkez Laboratuvarı Biyokimya Analizlerinde Onay Destek Sistemi Geliştirilmesi ve Validasyonu
(Tıp Fakültesi, 2020)The autoverification (AV) system in medical laboratories is a process in which computer-based algorithms automatically take actions on laboratory test results without the need for manual intervention by laboratory employees ... -
Haemophilus İnfluenzae'larda Tiplendirme Yöntemleri ve Önemi
(Sağlık Bilimleri Enstitüsü, 2021)Haemophilus influenzae is a gram-negative, cocobacilli or bacillus bacterium that can cause systemic and invasive infections. Serotyping of H.influenzae can be done conventionally by capsule-specific antisera or ... -
Hücre Kültüründe Aromataz/Sirtuin-1 Etkileşiminin miRNA İfade Düzeyine Olan Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)Kartal, Y. Evaluation of the Relationship Between Aromatase/Sirtuin-1 Interaction and miRNA Expression in Human Neuroblastoma Cells, Hacettepe University Graduate School of Health Sciences Physiology Programme Doctor of ... -
Improvement of Germ Stem Cell Pool by Leptin Supplementation and Gene Editing for Male Infertility
(Sağlık Bilimleri Enstitüsü, 2020-06-12)Infertility affects up to 12-15% of sexually active couples, and male factors contribute about 30-55% of these cases. Infertility can be caused by injuries, genetic factors, exposure to toxicants, immune-suppressive and ... -
İlaç Yeniden Konumlandırma Yaklaşımı ile Alfa Tübülin Asetilasyonunu Arttırabilecek Bileşiklerin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Drug repurposing approach is used to identify new indications of drugs outside the scope of their original indications. This approach has been used to identify effective compounds for neurodegenerative diseases. Axonal ... -
İnsan Granüloza Hücresi Mitokondriyon Fonksiyonu ile AMH ve Östrojen İlişkisi
(Tıp Fakültesi, 2021)Anti-Müllerian Hormone (AMH) and estrogen are essential hormones in human ovarian folliculogenesis. AMH and estrogen are produced by granulosa cells. It is known that mitochondria in human granulosa cells are important for ... -
İnsan Serum Bütirilkolinesterazının Olası Lipolitik Aktivitesi-Lipid Metabolizması ile İlişkisi.
(Sağlık Bilimleri Enstitüsü, 2021-01-21)Cholinesterases (AChE and BChE) terminate acetylcholine-induced neurotransmission at cholinergic synapses in muscle-nerve junctions. We previously showed BChE expression is regulated by essential fatty acids. The similarity ...
