Organophosphorus (OP) pesticides are irreversible inhibitors of cholinesterases [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)]. The OPs cause the acute toxic effect by covalent binding to a serine amino ...

The aim of this study is to determine the gene-based homogeneous subgroups of acute myeloblastic leukemias using the gene expression profiles of renin angiotensin system, the determination of biomarker potentially genes ...

Özen G., In Vitro Analysis of Resistance to Chemotherapeutics in Colon Cancer by Metabolomic and Fluxomic Studies, Hacettepe University Graduate of Health Sciences, Analytical Chemistry Program, Ph.D. Thesis, Ankara, 2019. ...

Essential oils have been used in cosmetic products for centuries. Its use for many years can be perceived as a reassuring factor; however, some of these oils can be dangerous for consumers through transdermal absorption ...

AFM1 is the hydroxylated metabolite of AFB1, and it is formed in the liver by cytochrome P450 enzymes and can be secreted into the urine, feces and milk of mammals. Since AFM1 is a carcinogenic, cytotoxic, teratogenic, ...

Mohammadi Nejad S. Evaluation of Developmental Toxicity of Ethephon Using Embryonic Stem Cell Model. Hacettepe University, Graduate School of Health Sciences, Pharmaceutical Toxicology Program, Doctor of Philosophy Thesis, ...

Down Syndrome is a common genetic disorder arising due to the condition that humans having an additional chromosome within 21st chromosome couple. Metabolomics is identification and quantification of small molecule metabolites ...

To evaluate the influence of the parameters predicted to develop nephrotoxiciy and the incidence of acute renal failure on the development of nephrotoxicity 30 patients who underwent intravenous colistin therapy for at ...

Atmaca, L., Investigation of Interactions of Antineoplastic Drugs with DNA by UV-Visible Region Spectroscopy, Hacettepe University Graduate School of Health Sciences Department of Analytical Chemistry Master’s Thesis, ...

Cancer is the one of the most difficult disease to detect and treat. By omic technologies it has been analyzed at molecular level about cancer. Among the omic technologies Proteomic, has been studied intensively worldwide, ...