Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disease, which is caused by irreversible loss of neurons in the hippocampus and cortex regions of the brain. Although the molecular mechanism ...

The aim of this project is to design inhibitors for GST P1-1 and test their effectiveness on breast cancer cells. For this purpose benzoxazole, benzimidazole, benzothiazole derivative compounds were synthesized. Recombinant ...

Cardiovascular complication is the main cause of mortality in diabetes mellitus. Beta blockers are groups of drugs that used in the treatment of heart disease in diabetes mellitus. The object of this study is to investigate ...

Telomerase mediated telomere targeted therapy represents a new approach in cancer therapy. In this study, I report that the nucleoside analogue 6-thio-2’-deoxyguanosine (6-thio-dG) is recognized by the telomerase ...

In this study, a new micellar electrokinetic capillary chromatography (MEKC) method was developed to analysis of Leflunomide in pharmaceutical preparations. Best results in the MEKC method were obtained by the use of pH ...

Myeloperoxidase (MPO) has been purified from human leucocytes obtained by leukapheresis, and kinetic properties were determined, nitrite oxidation and tyrosine nitration catalyzed by the purified enzyme have been studied. ...

The incidence of breast cancer is rapidly increasing and it is one of the major causes of death. The molecular changes leading to malignant transformation and metastasis of mammary cells is studied intensively. The expression ...

Butyrylcholinesterase (BChE) synthesized in liver is mostly associated with the detoxification of xenobiotics. Recently we have shown that in sedentary young males, application of exercise and/or conjugated linoleic acid ...

Dönmez, B. Synthesis of New Acetylsalicyclic Acid Derivatives Via Amino Acids and Amıno Alcohols, Hacettepe University Health Sciences Institute M.Sci. Thesis in Basic Pharmaceutical Sciences, Ankara, 2018. In this study, ...

Nowadays, a large number of cancer-related research is being conducted, which is one of the most difficult and deadly diseases to treat. Thanks to one of these studies, proteomics analysis, which is one of the omic techniques, ...