Nörolojik Bilimler ve Psikiyatri Enstitüsü: Recent submissions
Now showing items 1-20 of 46
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Periferik Sinir Continous Teta Burst Stimülasyonunun (Periferik-cTBS) Kortikal Uyarılabilirlik Üzerine Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024-06-29)Panpallı Ateş, M., Effect of Peripheral Nerve Continuous Theta Burst Stimulation (“Peripheral-cTBS”) on Cortical Excitability, Hacettepe University Institute of Health Sciences -Advanced Neurological and Psychiatric Sciences ... -
Çocukluk Çağı Epilepsi Hastalarında Erken Senesens Biyobelirteçleri ve Komorbid Bilişsel Etkilenme ile İlişkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024-07-03)Senescence, a steady loss of proliferative capacity triggered by complex pathways, has been studied in neurodegenerative diseases but remains obscure in epilepsy. This study aims to investigate whether the chronic stress ... -
Otizm Spektrum Bozukluğunda Nöroinflamasyonun Sinaptik Plastiklik Üzerine Etkileri
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024-02-22)Ünal D. The Effects Of Neuroinflamation On Synaptic Plasticity In Autism Spectrum Disorders, Hacettepe University Graduate School of Health Sciences Basic Neurological Sciences (Neuroscience) Program, Doctor of ... -
Alzheimer Hastalığında serum proteomik analizleri ile yeni biyobelirteçlerin araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2024)Current diagnostic criteria set for Alzheimer’s Disease (AD) is not sufficient for accurate prediction of the pathology. The use of CSF and PET biomarkers increase the accuracy of diagnoses but they are limited for widespread ... -
The Investigation the Role of Reduced Folate Carrier 1 in the Models of Ischemic Stroke and Retinal Ischemia
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023)Gurler, G., The Investigation the Role of Reduced Folate Carrier 1 in the Models of Ischemic Stroke and Retinal Ischemia, Hacettepe University, Graduate School of Health Sciences, Neuroscience Program, Doctor of Philosophy ... -
Pediyatrik ve Erişkin Hemofagositik Sendromların Tanı ve Tedavi Uygulamalarının Gözden Geçirilmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023-09-27)Hemophagocytic syndromes are rare, life-threatening conditions characterized by hypercytokinemia, systemic inflammation, and overstimulation of the immune system leading to multi-organ failure. Primary Hemophagocytic ... -
Multipl Skleroz ve Parkinson Hastalarında Neopterin Düzeyi ve Kinürenin Yolağının İnflamasyon ve Nörodejenerasyon Üzerine Etkisi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023)ABSTRACT Yavas, I. The Effect of Neopterin Level and Kynurenine Pathway on Inflammation and Neurodegeneration in Patients with Multiple Sclerosis and Parkinson's. Hacettepe University Graduate School Health Sciences ... -
Yetersiz Perisinaptik Astrosit Glikojeni Kullanımının Nöroinflamatuvar ve Davranışsal Etkilerinin İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023)Several findings suggest that the brain energy demand is mostly localized at the synapses, and glycogen in the perisynaptic astrocytic endfeet serves as the main actor that matches the synaptic energy supply and demand. ... -
Optogenetik uyarımla nf-κb aktivasyonu yapan bir yöntemin mss'de inflamasyonun primer depresyon patofizyolojisindeki rolünün incelenmesi amacıyla ın vıvo koşullar için geliştirilmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023-01-05)One of the critical limitations of the studies examining the effects of neuro-inflammation on depression is not implementing a protocol compatible with the pathophysiology of primary depression instead of using a protocol ... -
DOPA Yanıtlı Distoni Fare Modelinde Striatal Kolinerjik Sistemin Rolü
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022-05-26)Dystonia, which is the third most common movement disorder, is a heterogeneous group of diseases both etiologically and pathophysiologically. Striatal cholinergic dysfunction is a common pathophysiologiccal mechanism ... -
Dişi ve Erkek Farelerde Depresyonun Stres ve Optogenetik Modelinde MSS-Kökenli Nöroinflamasyonun İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022)There is ample evidence for the role of inflammatory signaling pathways in depression. However, in these studies, depression was modeled either by bacterial endotoxins or by acute stress, usually studied only in male animals ... -
Molecular Motor Contractıle Mechanısm of Retınal Perıcytes
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020)Although it is known that capillary pericytes function in the regulation of capillary tone and blood flow, the contractile proteins involved in these processes are unidentified. It is likely that α-SMA functions as a part ... -
Short-Hairpin Rna Silencing Of Endogenous Fibroblast Growth Factor 2 In Rat Hippocampus Increases Anxiety Behavior
(Elsevier Science Inc, 2011)Background: The fibroblast growth factor system has been implicated in the pathophysiology of mood disorders in humans and in affective behavior in animal models. However, the studies have been either correlative or involved ... -
The Neurophysiologic Frequency Of Hereditary Neuropathy With Liability To Pressure Palsy In Entrapment Neuropathies
(Türk Nöroloji Derneği, 2016)"Objective: Hereditary neuropathy with liability to pressure palsy (HNPP) needs to be differentiated from entrapment neuropathies due to differences in the treatment management. Materials and Methods: Among 5075 patients ... -
Thrombotic Distal Middle Cerebral Artery Occlusion Produced By Topical Fecl3 Application: A Novel Model Suitable For Intravital Microscopy And Thrombolysis Studies
(Nature Publishing Group, 2011)Intravital or multiphoton microscopy and laser-speckle imaging have become popular because they allow live monitoring of several processes during cerebral ischemia. Available rodent models have limitations for these ... -
What is a Pericyte?
(International Society for Cerebral Blood Flow & Metabolism, 2016)Pericytes, spatially-isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting capillaries and then dying. ... -
Refractory Lesional Parietal Lobe Epilepsy: Clinical, Electroencephalographic and Neurodiagnostic Findings
(Aves, 2016)Introduction: Specialized centers, in the management and surgical treatment of medically refractory epilepsy, emphasize the importance of differentiating the varieties of localization related epilepsies. There has been ... -
Plasma Glycine and Serine Levels in Schizophrenia Compared to Normal Controls and Major Depression: Relation to Negative Symptoms
(Oxford Univ Press, 2004)Previous Studies have suggested decreased N-methyl-D-aspartate (NMDA)-type glutamate receptor function may contribute to increased negative symptoms in patients with schizophrenia. Consistent with this hypothesis, glycine, ... -
Inhibiting 12/15-Lipoxygenase To Treat Acute Stroke In Permanent And Tpa Induced Thrombolysis Models
(Elsevier Science Bv, 2018)12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, ... -
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation And Provides Neuroprotection
(Lippincott Williams & Wilkins, 2018)Background and Purpose-Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized ...
