Browsing Eczacılık Meslek Bilimleri Bölümü by Department "Farmasötik Toksikoloji"
Now showing items 1-20 of 99
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Akrilamid ve 5-Hidroksimetilfurfural'in Olası Genotoksik Etkilerinin Tek Hücre Jel Elektroforez Yöntemi ile İn Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2021)The cooking processes of foods containing carbohydrates forms acrylamide and 5-hydroxymethylfurfural (HMF) as a result of Maillard reaction. According to previous in vivo and in vitro tests, these two substances ... -
Alzheimer Hastalığının in vitro Modellerinde Herpes Simpleks Proteinlerinin Kompleman Sistem, Sitokinler ve Epigenetik Değişiklikler Üzerindeki Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)Alzheimer's disease (AD) is characterized by decline in cognitive functions and dementia. Most cases are sporadic. However, some of these cases may develop from genetic or epigenetic origins. Additionally, it has been ... -
An Exploratory Study Of Neopterin And Kynurenine Pathway In Pterygium
(2019)Pterygium is an inflammatory, vascular and degenerative disorder with unknown aetiology. The aim of this study was to evaluate the changes in neopterin levels, reflecting T-cell immunity, and the kynurenine pathway, the ... -
An In Vitro Study On The Cytotoxicity And Genotoxicity Of Silver Sulfide Quantum Dots Coated With Meso-2,3-Dimercaptosuccinic Acid
(2019)Objectives: Silver sulfide (Ag2S) quantum dots (QDs) are highly promising nanomaterials in bioimaging systems due to their high activities for both imaging and drug/gene delivery. There is insufficient research on the ... -
Ankara İlinde Reçetelenen İlaçlara Bağlı İstenmeyen Etkilerin İzlenmesi ve Farmakovijilans Konusunda Farkındalığın Artırılması
(Sağlık Bilimleri Enstitüsü, 2017)Temiz Nemutlu N. Monitoring the Unintended Effects of Prescribed Drugs in Ankara and Improving the Awareness of Pharmacovigilance. Hacettepe University Institute of Health Sciences, Thesis of Master ... -
Anti-Cancer Effects of 3,5-Dimethylaminophenol in A549 Lung Cancer Cells
(2018)Exposure to 3,5-dimethylaminophenol (3,5-DMAP), the metabolite of the 3-5-dimethylaniline, was shown to cause high levels of oxidative stress in different cells. The aim of the present work was to observe whether this ... -
Antigenotoxic Properties of Paliurus Spina-Christi Mill Fruits and Their Active Compounds
(2017)Background Paliurus spina-christi Mill. (PS) fruits are widely used for different medical purposes in Turkey. Like in many medicinal herbs the studies concerning their activity, the activities of PS are also not well ... -
Antioxidants And Selenocompounds Inhibit 3,5-Dimethylaminophenol Toxicity To Human Urothelial Cells
(2019)Exposure to alkyl anilines may lead to bladder cancer, which is the second most frequent cancer of the urogenital tract. 3,5-dimethylaniline is highly used in industry. Studies on its primary' metabolite 3,5-dimethylaminophenol ... -
Assessment Of Genotoxic Effects Of Pendimethalin In Chinese Hamster Over Cells By The Single Cell Gel Electrophoresis (Comet) Assay
(Turkish Pharmacists Association, 2017)Objectives: Pendimethalin (N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzeneamine) is a dinitroaniline herbicide compound which selectively controls weeds. It is a cell division and growth inhibitor. It descends plants in ... -
Aşılarda Kullanılan Koruyucu ve Adjuvan Maddelerin Olası Toksik Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022)The World Health Organization defines vaccines as “pharmaceutical products that enable our immune system to recognize and fight pathogens such as viruses and bacteria and protect our body against the diseases caused by ... -
Bisfenol Türevlerinin Oksidatif Stres Parametreleri Üzerine Etkilerinin HepG2 Hücrelerinde Karşılaştırmalı Olarak Değerlendirilmesi.
(Sağlık Bilimleri Enstitüsü, 2018)Bisphenols belong to a chemical group known as diphenylmethanes and widely used in the production of polycarbonate plastics, as basic chemicals in the resin coating of food and beverage tins. These substances are suggested ... -
Chronopharmacodynamics Of Drugs In Toxicological Aspects: A Short Review For Clinical Pharmacists And Pharmacy Practitioners
(2012)For many decades, researchers are aware of the importance of circadian rhythm in physiological/biochemical properties and drug metabolism. Chronopharmacology is the study of how the effects of drugs vary with biological ... -
Chronopharmacokinetics Of Drugs In Toxicological Aspects: A Short Review For Pharmacy Practitioners
(2012)A rough 24-hour cycle driven endogenously in biochemical, physiological or behavioral processes is called circadian rhythm. Chronobiology is the study of biological temporal rhythms. For decades, we know that the biological ... -
Cinsiyete dayalı farklılıklar açısından metil cıva ve tiyomersalin toksisitelerinin insan nöroblastoma hücrelerinde karşılaştırmalı olarak değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-12-09)Depending on exposure time and concentration, organic mercury compounds cause significant neurotoxic effects, ranging from deterioration in motor development and cognitive activities to severe neuromotor alterations. It ... -
Çinko Oksit ve Bakır Oksit Nanoparçacıklarının in Vitro Sistemler Üzerindeki Toksik Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2017-09)Zinc oxide (ZnO) and copper oxide (CuO) NPs are commonly used metal nanoparticles with a high toxicity potential. However, information on toxicity mechanisms like other NPs, is limited. In this study, the possible ... -
Detection Of Neopterin In Tear Samples
(Walter De Gruyter Gmbh, 2016)The main goal of the present study was to detect neopterin concentrations in human tear samples and to evaluate its potential correlation with serum neopterin levels. For this purpose, 20 systemically healthy volunteers ... -
Dibutil Ftalatın İnsan Akciğer Hücre Hattına Toksik Etkilerinin Değerlendirilmesi ve Askorbik Asit ve N-Asetilsisteinin Olası Koruyucu Etkileri
(Sağlık Bilimleri Enstitüsü, 2020)Endocrine disruptings are chemical substances which are generally produced by humans that disrupt the normal functioning of the body by imitating or blocking hormones. The mostly studied phthalate derivative is ...
