Farklı Beden Kütle Indekslerine Göre Serum Visfatin Düzeyi ile Metabolik Parametreler Arasındaki Ilişki

Abstract

This study was conducted in individuals whose BMIs were different with the purpose of evaluating the relationship between the grade of obesity and serum visfatin, role of serum visfatin in the relation between obesity and insulin resistance, and association of serum visfatin levels with fasting insulin, fasting blood glucose and lipid parameters with the enrolment of 55 female and 35 male patients between 18-65 years of age who admitted to the outpatient clinics of Family Medicine and Internal Medicine of the Afyon Kocatepe University Hospital and who were free of any known chronic systemic, endocrinal and neurologic pathologies. Dietary habits questionnaire was applied to the patients and body analyses were performed. Patients enrolled in this study were applied a questionnaire including their personal information, dietary habits and status of physical activities. Their length and body weight were measured, BMIs were calculated, and body fat percentage and waist circumference (in centimetre) were measured. In addition, routine biochemical parameters (lipid profiles [total cholesterol, triglyceride, HDL-cholesterol, LDLcholesterol, VLDL-cholesterol], fasting blood glucose, fasting insulin) and serum visfatin levels of patients were tested, and they were evaluated according to their BMIs. At the end of the study, minimal serum visfatin level was found 5.1 mg/dL, maximal serum visfatin level was found 26.8 mg/dL and mean serum visfatin level was found 10.7 mg/dL. Serum visfatin levels of patients were not found to be correlated with their age, gender and waist circumference, but it was determined to be correlated negatively with body fat percentage moderately. There found to be a statistically significant relation between BMI and serum visfatin level. It was determined that mean serum visfatin level of patients whose BMI values were lower than 25 was significantly higher than others. As BMI increased, serum visfatin level decreased. And, as examined the relationship between serum visfatin level and biochemical findings, while there were no statistically significant relation between serum visfatin level and cholesterol, triglyceride, HDLcholesterol, LDL-cholesterol as well as VLDL-cholesterol, there found to be a statistically significant relation between serum visfatin level and fasting blood glucose as well as fasting insulin. There found to be no statistically significant relation between serum visfatin level and sporting or doing physical exercise as well as smoking. As a result of the data obtained by this study, serum visfatin resulted in lower levels in patients with high BMI. Negative correlation between serum visfatin level and fasting blood glucose as well as fasting blood insulin indicates that serum visfatin level may be associated with the mechanism of insulin resistance in obesity.