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Pinealectomy Aggravates and Melatonin Administration Attenuates Brain Damage in Focal Ischemia
(Sage Publications Inc, 1999)
Large infarcts develop in pinealectomized rats subjected to middle cerebral artery occlusion, which was attributed to loss of antioxidant action of melatonin. However, melatonin also has vascular actions, and pinealectomy ...
Endothelial Nitric Oxide Synthase-Dependent Cerebral Blood Flow Augmentation By L-Arginine After Chronic Statin Treatment
(Sage Publications Inc, 2000)
Nitric oxide, a product of nitric oxide synthase activity, relaxes vascular smooth muscle and elevates brain blood flow. We evaluated the importance of eNOS to cerebral blood flow augmentation after L-arginine infusion and ...
Mechanisms Of Motor Dysfunction After Transient Mca Occlusion - Persistent Transmission Failure In Cortical Synapses Is A Major Determinant
(Lippincott Williams & Wilkins, 1998)
Background and Purpose-Failure of prompt motor recovery after spontaneous recirculation or thrombolytic therapy may be due to an unsatisfactory restoration of synaptic activity within cortex and/or blockade of electrical ...
Prolonged Therapeutic Window for Ischemic Brain Damage Caused by Delayed Caspase Activation
(Sage Publications Inc, 1998)
Apoptotic cell death is prominent in neurodegenerative disorders, such as Alzheimer's disease and Huntington's disease? and is found in cerebral ischemia. Using a murine model of delayed cell death, we determined that ...
Role of Endothelial Nitric Oxide Generation and Peroxynitrite Formation in Reperfusion Injury After Focal Cerebral Ischemia
(Lippincott Williams & Wilkins, 2000)
Background and Purpose-Reperfusion injury is one of the factors that unfavorably affects stroke outcome and shortens the window of opportunity for thrombolysis. Surges of nitric oxide (NO) and superoxide generation on ...
Reperfusion-Induced Oxidative/Nitrative Injury To Neurovascular Unit After Focal Cerebral Ischemia
(Lippincott Williams & Wilkins, 2004)
Background and Purpose-Use of thrombolysis in stroke is limited by a short therapeutic window because delayed reperfusion may cause brain hemorrhage and edema. Available evidence suggests a role for superoxide, NO, and ...
Vegf Protects Brain Against Focal Ischemia Without Increasing Blood-Brain Permeability When Administered Intracerebroventricularly
(Sage Publications Inc, 2005)
Delayed administration of vascular endothelial growth factor (VEGF) promotes functional recovery after focal cerebral ischemia. However, early intravenous injection of VEGF increases blood-brain barrier (BBB) leakage, ...