Cholinesterases (AChE and BChE) terminate acetylcholine-induced neurotransmission at cholinergic synapses in muscle-nerve junctions. We previously showed BChE expression is regulated by essential fatty acids. The similarity ...

Drug resistance against chemotherapy is one of the main factors limitating the success of cancer treatment. Several studies have reported that the expression level of the glutathione S-transferase P1 (GSTP1) isozyme from ...

Phenylketonuria is a rare hereditary metabolic disease characterized by deficiency of phenylalanine hydroxylase. The absence of enzyme causes blood phenylalanine levels to rise. If patients are not treated, irreversible ...

Inborn errors of bile acid synthesis (IEBAS) are autosomal recessively inherited disorders that are resulted from the deficiencies in the structure or function of the enzymes involved in the synthesis of bile acids, causing ...

Cystic fibrosis, the most common autosomal recessive disease, is caused by mutations in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene. In addition to CFTR mutations, modifier genes and environmental factors play ...

Dental treatments in diabetic patients have been reported to fail in the long term and these patients have more tooth extraction. It is aimed to investigate the odonto/osteogenic differentiation potential of the combination ...

Felekoglu, R., The Effect of Kojic Acid Derivatives with New Synthesized Antithyrosinase Activity on Cytotoxicity and Cell Death in the A375 Malign Melanoma Cell Line, Hacettepe University Graduate School of Health ...

FF-MAS oxysterol is a derivative of steroid, found in follicular fluid and involved in oocyte maturation. Hedgehog pathway is one of the many cell signaling mechanisms effective in cell proliferation and its effect on the ...

Extracellular Matrix (ECM) is the mechanical supportive structure for cells and tissues. Chronic damage may cause loss of ECM integrity that may result in fibrosis which is the progressive and irreversible accumulation of ...

The autoverification (AV) system in medical laboratories is a process in which computer-based algorithms automatically take actions on laboratory test results without the need for manual intervention by laboratory employees ...