Browsing Kök Hücre Bilimleri by Rights "info:eu-repo/semantics/openAccess"
Now showing items 1-18 of 18
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Characterization of Acute Myeloid Leukemia Stem Cells By Niche-Like Coculture System
(Sağlık Bilimleri Enstitüsü, 2019)AML heterogeneity show evidence of hierarchical cellular organization and at the top of this hierarchical structure there is a rare group of LSCs. It was mentioned that there is an association between LSCs and disease ... -
Değişik Kaynaklı MKH’lerin Detaylı Karakterizasyonu, Lenfohematopoezi Destekleyici Özellikleri ve İzolasyonunda CD271 Antijeninin Önemi
(Sağlık Bilimleri Enstitüsü, 2018)Mesenchymal Stem Cells (MSCs) are multipotent cells with self-renewal ability and form the basis for regenerative treatments. CD271 antigen is an effective marker for isolation of pure populations of MSCs from bone marrow ... -
Endokannabinoidler ve Reseptörlerinin İnsan Hematopoetik Kök Hücreleri ve Kemik İliği Kaynaklı Mezenkimal Kök Hücrelerindeki Varlığı ve Düzeyinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2017)Köse, S. The Effects of Endocannabinoids and Their Receptors on Human Bone Marrow Mesenchymal and Hematopetic Stem Cells. Hacettepe University Institude of Health Sciences, Ph.D. Thesis in Stem Cell Science, Ankara, 2017. ... -
Eritropoetin Uygulamasının Mezenkimal Kök Hücre Gen ifade Profiline Etkisi
(Sağlık Bilimleri Enstitüsü, 2018)Mesenchymal Stem Cells (MSC) have therapeutic importance because of their multipotency and immune modulation potentials. Erythropoietin is responsible for erytropoesis. However, EPO treatment of cells including mesenchymal ... -
Griscelli Sendromu Uyarılmış Pluripotent Kök Hücre Geliştirilmesi, Karakterizasyonu ve İn Vitro Hematopoetik Farklılaşması
(Sağlık Bilimleri Enstitüsü, 2018-04-04)Griscelli type 2 Syndrome (GS-2) is a rare, autosomal recessive immune deficiency syndrome. The RAB27A gene mutation in GS-2 patients results in the loss of function of T and NK cells. Induced pluripotent stem cells ... -
INVESTIGATING THE EFFECTS OF PKNOX2 AND ITS INTERACTORS IN P53 PATHWAY REGULATION IN BONE MARROW MESENCHYMAL STEM CELLS
(Sağlık Bilimleri Enstitüsü, 2023)Mesenchymal Stem Cells (MSC) are good platforms to study in-vitro molecular mechanisms. Like all cells, MSCs detect and respond to various stimuli with molecular signal mechanisms. p53 signal pathway is a well-known molecular ... -
İn Vitro Kültür Ortamında Kemik İliği Nişi Modellenmesine Yönelik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2018)Mesenchymal stem cells (MSC) are the widely used stem cell type in preclinical research, clinical studies and investigational new drug applications. Isolation of MSC can be provided from bone marrow and adipose tissue, and ... -
İnfantil Osteopetrozisli Hasta Uyarılmış Pluripotent Kök Hücreleri ile Osteoklast Defektinin Modellenmesi,Osteoklast ve Hematopoietik Niş İlişkisi
(Sağlık Bilimleri Enstitüsü, 2019)Malignant infantile osteopetrosis is an autosomal recessive disorder. The only available treatment is allogeneic hematopoietic stem cell transplantation. The objective of this study was to model hematopoietic niche in ... -
İnsan Göbek Kordon Veni CD146+ Hücrelerin ve Bu Hücrelerden Elde Edilen Matriks Proteinlerinin in vitro Biyofilm Modellerinde Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019)In the treatment of wounds, the application of cells or decellularized matrices with antimicrobial effects to the wound area has attracted attention in recent years. The aim of this thesis is to evaluate CD146+ stem cells ... -
İskelet Kası Dejenerasyonu Sürecinde Stromal Hücre Alt Gruplarının İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017)The characteristics of the skeletal muscle degeneration are muscle fiber atrophy and fibrosis. The genetic and cellular therapeutic approaches for skeletal muscle treatment remain incapable due to the fibrosis. Studies ... -
Kemik İliği Yağ Tabakasından Elde Edilen Mezenkimal Kök Hücrelerin Karakterizasyonu ve Subkutan Yağ ve Kemik İliği Kökenli Mezenkimal Kök Hücreleri ile Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2020-09)Bone marrow adipose tissue (BMAT) has different properties than other adipose tissues. Recent studies have shown the effects of bone marrow adipose tissue on development / progression of acute myeloblastic leukemia (AML), ... -
Mezenkimal Kök Hücre Üretiminde İn Vitro Temelli Metabolomik ve Analizler
(Sağlık Bilimleri Enstitüsü, 2020-02-12)Karaağaç Akyol, T. Metabolomic And Analyzes In In-Vitro Based On The Production Of Mesenchimal Stem Cells, Hacettepe University Graduate School of Health Sciences Stem Cells Program Doctor of Philosophy Thesis, Ankara, ... -
Mezenkimal Kök Hücrelerin Diamond Blackfan Anemisi Hastalığındaki Rolünün Aydınlatılması
(Sağlık Bilimleri Enstitüsü, 2018-07)In this thesis, the molecular etiology of Diamond Blackfan Anemia is tried to be enlightened. For this purpose, bone marrow mesenchymal and hematopoietic stem cells from the patients were comparatively analyzed with healthy ... -
Mezenkimal Kök Hücrelerin In Vıtro Koşullarda Testis Mikroçevresi ve Spermatogonyal Kök Hücre Havuzunun Korunmasına Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2019)Önen, S. Researching The Effect of Mesenchymal Stem Cells on the Testicular Microenvironment and the Spermatogonial Stem Cell Pool Under in vitro Conditions. Hacettepe University Graduate School of Health Sciences, Master ... -
Nörofibromatozis Tip 1(Nf1) Kaynaklı Mezenkimal Stromal Hücrelerin Detaylı Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2022-10-07)Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disease characterized by mutation in the neurofibromin (NF1) tumor suppressor gene. The lack of neurofibromin, the gene product, causes defects in the nervous ... -
Podosit Hasar Modelinde İndüklenmiş Mezenkimal Kök Hücrelerinin Etkisi
(Sağlık Bilimleri Enstitüsü, 2023-02-08)Sahan, OB., The Effect of İnduced Mesenchymal Stem Cells On Podocyte Injury Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, Ankara,2023. Self-renewal, ... -
The Effect of Melatonın on Hıppo Sıgnallıng Pathway in Dental Pulp Stem Cells
(Sağlık Bilimleri Enstitüsü, 2020)Dental pulp stem cells (DPSCs) are heterogeneous multipotent adult stem cells with high capacity to differentiate to both neuronal and non-neuronal cell lineage. Hippo pathway regulates diverse cellular processes, including ... -
Uyarılmış Pluripotent Kök Hücrelerin Araştırma Amaçlı Bankalanmasında Standardizasyon ve Kalite Süreci - Bir Uygulama Modeli: “Pedı-Stem”
(Sağlık Bilimleri Enstitüsü, 2020-06-18)Induced pluripotent stem cell (iPSC) is generated by genetic modification of any cell type of the body in laboratory conditions by transferring of embryonic stem cell-like pluripotent properties. iPSC is a cell model that ...
