Browsing Kök Hücre Bilimleri by Language "tur"
Now showing items 1-20 of 24
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AKUT MYELOBLASTİK LÖSEMİ (AML) HASTALIĞI HÜCRELERİNİN APTAMER TEMELLİ AKIM SİTOMETRİK PROFİLLENMESİ
(Sağlık Bilimleri Enstitüsü, 2023-02)AKCA O, Aptamer Based Flow Cytometric Profiling in Acute Myeloblastic Leukemia (AML) Disease Cells. Hacettepe University Graduate School of Health Sciences Stem Cell Program Master Thesis, Ankara, 2023. Aptamers are short, ... -
Apc Mutant Fare İntestinal Organoidlerinde Wnt Yolak Modülasyonunun Kök Hücreler Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ... -
Baş Boyun Kanserli Hastaların Tükürük Örneklerinden İzole Edilen Eksozom ve Bakterilerin, Sağlıklı Kemik İliği Mezenkimal Kök Hücreler Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-01-25)Recently, in the development of head and neck cancers, the components, which are responsible for the interaction between cells and surrounding healthy tissues, in the tumor microenvironment have become a burgeoning area. ... -
Değişik Kaynaklı MKH’lerin Detaylı Karakterizasyonu, Lenfohematopoezi Destekleyici Özellikleri ve İzolasyonunda CD271 Antijeninin Önemi
(Sağlık Bilimleri Enstitüsü, 2018)Mesenchymal Stem Cells (MSCs) are multipotent cells with self-renewal ability and form the basis for regenerative treatments. CD271 antigen is an effective marker for isolation of pure populations of MSCs from bone marrow ... -
Eritropoetin Uygulamasının Mezenkimal Kök Hücre Gen ifade Profiline Etkisi
(Sağlık Bilimleri Enstitüsü, 2018)Mesenchymal Stem Cells (MSC) have therapeutic importance because of their multipotency and immune modulation potentials. Erythropoietin is responsible for erytropoesis. However, EPO treatment of cells including mesenchymal ... -
Griscelli Sendromu Uyarılmış Pluripotent Kök Hücre Geliştirilmesi, Karakterizasyonu ve İn Vitro Hematopoetik Farklılaşması
(Sağlık Bilimleri Enstitüsü, 2018-04-04)Griscelli type 2 Syndrome (GS-2) is a rare, autosomal recessive immune deficiency syndrome. The RAB27A gene mutation in GS-2 patients results in the loss of function of T and NK cells. Induced pluripotent stem cells ... -
Hematopoetik Kök Hücre Gen Tedavi Kültür Koşulları ve Engraftman Optimizasyonu
(Sağlık Bilimleri Enstitüsü, 2021)RAG2 severe combined immunodeficiency (SCID) is a rare, inherited primary immunodeficiency (PID), characterized by a T-/B-/NK+ phenotype and is treated with hematopoietic stem cell (HSC) transplantation. When no suitable ... -
Hücre Tabaka Mühendisliği ile Göbek Kordonu Perisitlerinden Üç Boyutlu Damar Grefti Eldesi
(Sağlık Bilimleri Enstitüsü, 2018-01-25)In the case of limited accessibility of the autologous vessels and the disadvantages of synthetic scaffolds, small-diameter vascular grafts (SDVG) made from cellularized natural scaffolds are needed for the treatment of ... -
İn Vitro Kültür Ortamında Kemik İliği Nişi Modellenmesine Yönelik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2018)Mesenchymal stem cells (MSC) are the widely used stem cell type in preclinical research, clinical studies and investigational new drug applications. Isolation of MSC can be provided from bone marrow and adipose tissue, and ... -
İnfantil Osteopetrozisli Hasta Uyarılmış Pluripotent Kök Hücreleri ile Osteoklast Defektinin Modellenmesi,Osteoklast ve Hematopoietik Niş İlişkisi
(Sağlık Bilimleri Enstitüsü, 2019)Malignant infantile osteopetrosis is an autosomal recessive disorder. The only available treatment is allogeneic hematopoietic stem cell transplantation. The objective of this study was to model hematopoietic niche in ... -
İnsan Göbek Kordon Veni CD146+ Hücrelerin ve Bu Hücrelerden Elde Edilen Matriks Proteinlerinin in vitro Biyofilm Modellerinde Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019)In the treatment of wounds, the application of cells or decellularized matrices with antimicrobial effects to the wound area has attracted attention in recent years. The aim of this thesis is to evaluate CD146+ stem cells ... -
İNSAN SOMATİK HÜCRELERİNİN UYARILMIŞ PLÜRİPOTENT KÖK HÜCRELERE YENİDEN PROGRAMLANMASI SÜRECİNDE ARİLHİDROKARBON RESEPTÖRÜ SİNYALİZASYONUNDAKİ DEĞİŞİMLERİN İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2023)Sevindi S., Investigation of Changes in Arylhydrocarbon Receptor Signaling in the Reprogramming of Human Somatic Cells into Induced Pluripotent Stem Cells, Hacettepe University Graduate School of Health Sciences Department ... -
İskelet Kası Dejenerasyonu Sürecinde Stromal Hücre Alt Gruplarının İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017)The characteristics of the skeletal muscle degeneration are muscle fiber atrophy and fibrosis. The genetic and cellular therapeutic approaches for skeletal muscle treatment remain incapable due to the fibrosis. Studies ... -
Kemik İliği Mezenkimal Kök Hücrelerinde PKNOX2 Proteinin ATM ve RNF8 Proteinleri ile Etkileşimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2019)Donmez, N., Investigation of PKNOX2 Protein Interactions with ATM and RNF8 in Bone Marrow Derived Mesenchymal Stem Cells, Hacettepe University Graduate School Health Sciences Stem Cell Program Master Thesis, Ankara, 2019. ... -
Kemik İliği Yağ Tabakasından Elde Edilen Mezenkimal Kök Hücrelerin Karakterizasyonu ve Subkutan Yağ ve Kemik İliği Kökenli Mezenkimal Kök Hücreleri ile Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2020-09)Bone marrow adipose tissue (BMAT) has different properties than other adipose tissues. Recent studies have shown the effects of bone marrow adipose tissue on development / progression of acute myeloblastic leukemia (AML), ... -
Metabolom ve Transkriptom Profillemesi ile İnsan Kemik İliğinde Hematopoetik Niş Karakterizasyonu
(Çocuk Sağlığı Enstitüsü, 2015)In model organisms and animal experiments, it has been shown that hematopoietic stem cells (HSC) in bone marrow have special organizations and they provide this organization through special microenvironment called niche. ... -
Mezenkimal Kök Hücre Yaşlanmasında Nf-Κb/P65 ve Pknox2 Protein-Protein Etkileşimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2021)Mesenchymal stem cells undergo replicative senescence by cultivating in vitro and as the passage extends they lose their stem cell properties. Previous study of our group investigating proteomics of the co-immunoprecipitated ... -
Mezenkimal Kök Hücrelerin Diamond Blackfan Anemisi Hastalığındaki Rolünün Aydınlatılması
(Sağlık Bilimleri Enstitüsü, 2018-07)In this thesis, the molecular etiology of Diamond Blackfan Anemia is tried to be enlightened. For this purpose, bone marrow mesenchymal and hematopoietic stem cells from the patients were comparatively analyzed with healthy ... -
Mezenkimal Kök Hücrelerin In Vıtro Koşullarda Testis Mikroçevresi ve Spermatogonyal Kök Hücre Havuzunun Korunmasına Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2019)Önen, S. Researching The Effect of Mesenchymal Stem Cells on the Testicular Microenvironment and the Spermatogonial Stem Cell Pool Under in vitro Conditions. Hacettepe University Graduate School of Health Sciences, Master ... -
Nörofibromatozis Tip 1(Nf1) Kaynaklı Mezenkimal Stromal Hücrelerin Detaylı Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2022-10-07)Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disease characterized by mutation in the neurofibromin (NF1) tumor suppressor gene. The lack of neurofibromin, the gene product, causes defects in the nervous ...
