Browsing Kök Hücre Bilimleri by Funding "TÜBİTAK"
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Akut myeloblastik lösemi (aml) hastalığı hücrelerinin aptamer temelli akım sitometrik profillenmesi
(Sağlık Bilimleri Enstitüsü, 2023-02)AKCA O, Aptamer Based Flow Cytometric Profiling in Acute Myeloblastic Leukemia (AML) Disease Cells. Hacettepe University Graduate School of Health Sciences Stem Cell Program Master Thesis, Ankara, 2023. Aptamers are short, ... -
Allojenik Mezenkimal Kök Hücreler ve Mikroakışkan Sistemle Vücut Dışında Testisteki Spermatogonyal Kök Hücre Mikroçevresinin Devamlılığının Sağlanması
(Sağlık Bilimleri Enstitüsü, 2023)Chemoradiotherapeutics used in childhood cancers result in permenant infertility in half of male patients. Bone marrow derived mesenchymal stem cells (BMMSC) share some of their secretomes and their embryonic origin with ... -
Apc Mutant Fare İntestinal Organoidlerinde Wnt Yolak Modülasyonunun Kök Hücreler Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ... -
Apc Mutant Fare Modelinde Azaltılmış Bdnf Ekspresyonunun İntestinal Tümör Gelişimi Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023-04)Gök, A., Effects of Reduced Bdnf Expression on Intestinal Tumor Development in Apc Mutant Mouse Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, ... -
Hematopoetik Kök Hücre Gen Tedavi Kültür Koşulları ve Engraftman Optimizasyonu
(Sağlık Bilimleri Enstitüsü, 2021)RAG2 severe combined immunodeficiency (SCID) is a rare, inherited primary immunodeficiency (PID), characterized by a T-/B-/NK+ phenotype and is treated with hematopoietic stem cell (HSC) transplantation. When no suitable ... -
İnfantil Osteopetrozisli Hasta Uyarılmış Pluripotent Kök Hücreleri ile Osteoklast Defektinin Modellenmesi,Osteoklast ve Hematopoietik Niş İlişkisi
(Sağlık Bilimleri Enstitüsü, 2019)Malignant infantile osteopetrosis is an autosomal recessive disorder. The only available treatment is allogeneic hematopoietic stem cell transplantation. The objective of this study was to model hematopoietic niche in ... -
Oksidatif Stres Altında Mezenkimal Kök Hücrelerde Src-YAP Aktivitesi ve Apoptoz ile İlişkisi
(Sağlık Bilimleri Enstitüsü, 2024)One of the reasons for the post-transplantation loss of mesenchymal stem cells (MSCs), which are used in the treatment of many diseases with their immunomodulatory and regenerative properties, is oxidative stress-induced ... -
Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives Using Current Molecular Techniques and Technologies
(Sağlık Bilimleri Enstitüsü, 2024-02-09)EROL DUYAR, Ö.D. Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives using Current Molecular Techniques and Technologies. Hacettepe University Graduate School of Health Sciences Stem Cell Doctor of ... -
Sağlıklı İnsan Uyarılmış Pluripotent Kök Hücrelerinden (uPKH’lerden) NGN2, LHX3 ve ISL1 Üçlü Kasedi Kullanarak Motor Nöron Eldesi
(Sağlık Bilimleri Enstitüsü, 2023)Neurodegenerative diseases are progressive and fatal diseases that reduce the standard of living of individuals and cause significant functional losses. Amyotropic lateral sclerosis (ALS) is a disease caused by motor neurone ... -
Sağlıklı İnsan Uyarılmış Pluripotent Kök Hücrelerinden Kortikal Nöron Elde Edilmesi
(Sağlık Bilimleri Enstitüsü, 2023)Induced pluripotent stem cells (iPSC) are a unique resource for personalized treatment, disease modeling and drug trials. Target tissue and organ formation can be achieved with various transcription factors or small molecules ...