One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ...

Malignant infantile osteopetrosis is an autosomal recessive disorder. The only available treatment is allogeneic hematopoietic stem cell transplantation. The objective of this study was to model hematopoietic niche in ...

Induced pluripotent stem cells (iPSC) are a unique resource for personalized treatment, disease modeling and drug trials. Target tissue and organ formation can be achieved with various transcription factors or small molecules ...