Deneysel Epilepsi Modelinde Prolaktin Hormon Düzeyinin Hipokampüs Üzerine Etkisi

Abstract

Epilepsy is the one of the most common type of the cerebral diseases. Seizure is defined as the sudden, abnormal and unexpected electrical discharge that results in clinical change and generally they are short episodes which terminate spontenously. Distractable or untreatable seizures can cause neuronal death or injury which can result in structural and cognitive demolition in brain. Because of this, nowadays intensive studies about epilepsy and the treatment are going on. In recent studies the authors found out an relationship between epilepsy and prolactin hormone. In experimental epilepsy models, some authors found that the increasing prolactin hormone level causes less cell death and damage in hippocampal region. In this research the aim is searching if the prolactin hormone level rise after epileptic seizures and what is the effect of increasing prolactin hormone level on hippocampus cell death/injury in experimental epilepsy model in rats. In this research sum of 24 Wistar-Hannover type female rats were used. The groups consist of 8 rats for the comparable results in a statistical manner. All the grups were taken blood sample for prolactin analysis and then 2. and 3. groups have had pilocarpine induced experimental epileptic seizure. After seizure blood samples were taken again and all the groups sacrified. Hipocampus specimens obtained for the histopathological evaluation with flouressence dyes in light microscope. This study showed that prolactine level after epileptic seizure was significantly high. Hipocampal damage was significantly high in 2. and 3. groups in comparison with control group. But a correlation not found between prolactine hormon level and the hipocampal damage.