Başlık için Kanser Enstitüsü Tez Koleksiyonu listeleme
Toplam kayıt 70, listelenen: 35-54
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Kanser Tanısı Alan Hastaların Birinci Derece Yakınlarında Sigara Bırakma Davranışının Değerlendirilmesi
(Kanser Enstitüsü, 2018)Tobacco use is one of the most important causes of morbidity and mortality. As a consequence, quitting smoking is a fundamental aim of primary prevention of diseases. Diagnosing a smoker or his/her relative with cancer may ... -
Kolon Kanserli Hastalarda Interlökin 21 ve Interlökin32 Gen Ekspesyon Düzeyleri ve Metastaz Ilişkisi
(Kanser Enstitüsü, 2014)Tumor microenvironment contains tumor cells, immune cells, stroma and stroma associated immune cells. This microenvironment of the immune system cells release chemokines and cytokines which play an important role in the ... -
Kolorektal Kanserlerde Th17 İlişkili IL-17, IL-21 ve IL-22 Sitokinlerinin Ekspresyon Düzeylerinin Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2019)Immune system cells and released cytokines in tumor microenvironment have a very important role in cancer prognosis. Also, T-helper 17 (Th17) cells have been frequently found in many tumors microenvironment and their effects ... -
Kronik Periodontiti Olan Hastalarda Kanser İnsidansının Değerlendirilmesi
(Kanser Enstitüsü, 2017)Previous studies have noted possible associations between periodontitis and the risk of various cancers, particularly head and neck cancers, esophageal cancer, lung cancer, pancreatic cancer, breast cancer and non-Hodgkin ... -
Küçük Hücreli Dışı Akciğer Kanserinde Serum ve Glukokortikoid ile İndüklenebilen Kinaz 1 (SGK-1) İnhibisyonunun Epidermal Büyüme Faktörü Reseptörü (EGFR) Aracılı Sinyal Yolağı Üzerindeki Etkisi
(Kanser Enstitüsü, 2018)Oncogenic activation of epidermal growth factor receptor (EGFR) signaling exists in non-small cell lung cancer (NSCLC). Increased expression of Serum and Glucocorticoid Inducible Kinase 1 (SGK-1) in NSCLC cells was found ... -
Meme Kanseri Hücreleri Tarafından Üretilen Fibronektinin Miyeloid Hücre Karakteri Üzerine Etkisi
(Kanser Enstitüsü, 2019)Basal-like breast cancer (BLBC) possess high capacity to regulate inflammation and identified with high-level myeloid cell infiltration. Extracellular matrix components produced by tumor cells, e.g. fibronectin (FN), can ... -
Meme Kanseri Hücrelerinde Kostimülatör B7 Ailesi Ligandlarının Ekspresyonu ve Yardımcı T Hücre Yanıtları Üzerine Etkisi
(Kanser Enstitüsü, 2013)B7 ligands are the most critical costimulatory molecules that regulate T cell responses. Although these molecules are mainly expressed on professional antigen presenting cells, they may also be expressed on tumor cells. ... -
Meme Kanseri Hücrelerinde Pı-103 Inhibitörünün Aktive Reseptör Tirozin Kinaz Ekspresyonuna Etkisinin Incelenmesi
(Kanser Enstitüsü, 2014)Oncogenic activation of PI3K/Akt/mTOR signaling pathway is frequently seen in breast cancer. Inhibition of signaling pathway by PI3K inhibitors, tyrosine kinase inhibitors and/or monoclonal antibodies causes increase in ... -
Meme Kanseri Modelinde Myeloid Kökenli Hücrelerin Immün Kompartmanlardaki Dağılımının Anti-Tümör Yanıtlara Yansıması
(Kanser Enstitüsü, 2013)Myeloid cells of peripheral blood, bone marrow and spleens from NMU induced mammary tumor bearing Sprague-Dawley rats were examined in this study. Myeloid derived suppressor cells (MDSCs) in tumor bearing rats are defined ... -
Meme Kanserinde Göğüs Duvarı ve Lenfatik Işınlamada 3 Boyutlu Konformal Radyoterapi ile Yoğunluk Ayarlı Radyoterapi.
(Kanser Enstitüsü, 2013)Breast/chest wall (CW) and lymphatic irradiation for breast cancer is one of the most difficult techniques in radiotherapy. In this study, forward and inverse planing IMRT, hybrid IMRT plans were compared with the corresponding ... -
Meme Kanserinde, Il-1β ile Tetiklenen Epitelyal Mezenkimal Dönüşümde Hücre İskeleti Dinamiklerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023-03)The presence of interleukin (IL)-1β, a proinflammatory cytokine, has been demonstrated in the breast cancer microenvironment. IL-1β supports cell survival, proliferation, adhesion, invasion, and migration mechanisms. It ... -
Meme Kanserinde, Normal Fibroblastlar ve Kanserle İlişkili Fibroblastların Monosit Çağrılması, Makrofaj Polarizasyonu ve İnvazyona Etkisi
(Kanser Enstitüsü, 2018)GÖK YAVUZ B., The Effect of Cancer Associated Fibroblasts and Normal Fibroblasts on Monocyte Recruitment, Macrophage Polarization and Invasion in Breast Cancer. Hacettepe University Institute of Health Sciences Ph.D Thesis ... -
Mikozis Fungoides Mikroçevresinde Bulunan Dermal Fibroblastların Anti-Tümör İmmün Yanıta Etkisi
(Sağlık Bilimleri Enstitüsü, 2017-12)Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. The interaction of the neoplastic lymphocytes with their microenvironment is of crucial importance in disease progression. Cancer associated ... -
Mikrotübül İnhibitörlerinin Kanser Hücrelerinde Tehlike-İlişkili Moleküler Desen Düzeylerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Cancer cells are proliferate rapidly and uncontrolled. Chemotherapeutics such as vinorelbine and colchicine affect the cell cycle and DNA synthesis mechanism; they causes cells to be kept in the G2 / M phase by preventing ... -
Modulation of Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR)-GITR Ligand (GITRL) Interaction in Breast Cancer Cells Under the Control of Ataxia Telangiectasia Mutated (ATM) Promoter
(Kanser Enstitüsü, 2017-07-21)Treatment response for basal-like breast cancers (BLBC) is limited and this aggressive breast cancer sub-type has poor prognosis and high mortality. Our first aim is to investigate ATM activity in BLBC cell lines with ... -
Pankreas Kanseri Hücre Hattında TFAM Ekspresyon Düzeyinin Hücre Fonksiyonları Üzerine Etkisi
(Kanser Enstitüsü, 2022-07-29)Pancreatic cancer is an aggressive malignancy with a poor prognosis. Early diagnosis and application of tumor-specific treatment are very important in pancreatic cancer. Therefore, new biomarkers are needed in the diagnosis ... -
Pankreas Kanserinde MUC1, MUC4, MUC16 Molekülleri ile Treg Hücreleri ve Epitelyal-Mezenkimal Transizyon Arasındaki İlişki
(Kanser Enstitüsü, 2020-08-14)Pancreatic cancer has a poor prognosis due to its increased invasion and metastasis capacity. Transmembrane mucins normally have as their functions to protect the epithelial tissues but their expression level is has been ... -
Pankreas Kanserinde Nectin-2 Ekspresyonu ile Sitotoksik T Hücre Fonksiyonları Arasındaki İlişki
(Kanser Enstitüsü, 2023)Checkpoint inhibitors such as anti-CTLA-4, anti-PD1 and anti-PDL-1 are used in the treatment of various cancers. However, they cannot be used in pancreatic cancer due to the lack of PDL-1 expression. Other checkpoint ... -
Prostat Kanserinde Tlr Agonistlerinin M1, M2 Makrofaj Polarizasyonunda Rolü
(Kanser Enstitüsü, 2019)It is well known that inflammation is effective in the development of prostate cancer. Macrophages in the tumor microenvironment are either anti-inflammatory M2-type that help tumor growth or pro-inflammatory M1-type that ... -
Prostat Ve Akciğer Kanserlerinin Vmat (Volümetrik Ayarlı Radyoterapi) ve Yart (Yoğunluk Ayarlı Radyoterapi) Tabanlı Tedavilerinde Termal Fotonötron Kontaminasyonunun İncelenmesi
(Kanser Enstitüsü, 2022)Yılmaz, E. Investigation of Thermal Photoneutron Contamination in VMAT (Volumetric Modulated Arc Therapy) and IMRT (Intensity-Modulated Radiation Therapy)-Based Treatments of Prostate and Lung Cancers, Hacettepe University ...