Browsing Kanser Enstitüsü Tez Koleksiyonu by Title
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Hacettepe Üniversitesi Onkoloji Hastanesinde Yatmakta Olan Hastalara Bakım Verenlerin Sosyodemografik Özelliklerinin ve Yaşam Kalitelerinin, Hastaların Yaşam Kalitesi Üzerine Etkisi
(Kanser Enstitüsü, 2022)Güner Üliç. P., The Effects of Sociodemographic Characteristics and Quality Of Life of Caregivers on Quality of Life of Inpatient Cancer Patients in Hacettepe University Oncology Hospital, Hacettepe University Graduate ... -
Helikal Tomoterapi ile Prostat Işınlamalarında Kritik Organ Dozlarının Cihaz İçi Parametrelere göre Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2017)The treatment planning of Tomotherapy depends on three device parameters, i.e. field width (FW), pitch (P) and modulation factor (MF). Various treatment plans can be generated with different combinations of these parameters. ... -
HER2 EKSPRESYONU OLAN MEME KANSERİ HÜCRELERİNDE ÖKARYOTİK ELONGASYON FAKTÖR-2 KİNAZ (eEF2K) AKTİVASYONUNUN ROLÜ
(Kanser Enstitüsü, 2021-06-22)Continuous activation of HER2 leads to the deregulation of various biological responses such as cell proliferation, survival, and migration, and tumor growth. eEF2K is a protein kinase involved in the regulation of protein ... -
Hipoksinin Anti-Tümor İmmün Yanıt Üzerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)Inhibition of tumor angiogenesis has been extensively utilized in the treatment of metastatic colorectal cancer and renal cell carcinoma. Complete disruption of tumor angiogenesis results in hypoxia which promotes tumor ... -
Inhibition of Serum and Glucocortıcoıd Inducible Kinase 1 (Sgk1) in Triple Negative Breast Cancer
(Kanser Enstitüsü, 2018-07-18)Glucocorticoid receptor overexpression leads to poor prognosis in breast cancer, particularly in triple negative phenotype. This poor prognosis has been shown to be due to the activation of SGK1 (serum and glucocorticoid ... -
Interactıon Mechanısms Between Small Cell Lung Cancer Cells And T Lymphocytes
(Kanser Enstitüsü, 2019-08)Tumors are capable of reshaping their microenvironment to escape from immune destruction. For this purpose, tumor cells initiate an immune regulatory program that is typically used by the normal cells to mitigate ... -
Investigation of Lung Cancer Cell Culture Supernatants Activated with Tlr Agonists Effect on Macrophage Polarization
(Kanser Enstitüsü, 2018)It is well known that inflammation is involved in the development of lung cancer. Macrophages in the tumor microenvironment are the anti-inflammatory M2 type and anti-tumor type M1. Inflammatory cytokines, such as IL-1β, ... -
İnsan Makrofajlarında Nitrik Oksit Sentaz 2 (Nos2) İfade ve Aktivitesinin Bazal Benzeri Meme Kanseri Hücrelerinden Üretilen Faktörler Varlığında İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022)Macrophages are the leading cells of innate immunity in the immune response against pathogens and are involved in the regulation of adaptive immune responses. Macrophages with microbicidal properties promote the proinflammatory ... -
Kanser Tanısı Alan Hastaların Birinci Derece Yakınlarında Sigara Bırakma Davranışının Değerlendirilmesi
(Kanser Enstitüsü, 2018)Tobacco use is one of the most important causes of morbidity and mortality. As a consequence, quitting smoking is a fundamental aim of primary prevention of diseases. Diagnosing a smoker or his/her relative with cancer may ... -
Kolon Kanserli Hastalarda Interlökin 21 ve Interlökin32 Gen Ekspesyon Düzeyleri ve Metastaz Ilişkisi
(Kanser Enstitüsü, 2014)Tumor microenvironment contains tumor cells, immune cells, stroma and stroma associated immune cells. This microenvironment of the immune system cells release chemokines and cytokines which play an important role in the ... -
Kolorektal Kanserlerde Th17 İlişkili IL-17, IL-21 ve IL-22 Sitokinlerinin Ekspresyon Düzeylerinin Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2019)Immune system cells and released cytokines in tumor microenvironment have a very important role in cancer prognosis. Also, T-helper 17 (Th17) cells have been frequently found in many tumors microenvironment and their effects ... -
Kronik Periodontiti Olan Hastalarda Kanser İnsidansının Değerlendirilmesi
(Kanser Enstitüsü, 2017)Previous studies have noted possible associations between periodontitis and the risk of various cancers, particularly head and neck cancers, esophageal cancer, lung cancer, pancreatic cancer, breast cancer and non-Hodgkin ... -
Küçük Hücreli Dışı Akciğer Kanserinde Serum ve Glukokortikoid ile İndüklenebilen Kinaz 1 (SGK-1) İnhibisyonunun Epidermal Büyüme Faktörü Reseptörü (EGFR) Aracılı Sinyal Yolağı Üzerindeki Etkisi
(Kanser Enstitüsü, 2018)Oncogenic activation of epidermal growth factor receptor (EGFR) signaling exists in non-small cell lung cancer (NSCLC). Increased expression of Serum and Glucocorticoid Inducible Kinase 1 (SGK-1) in NSCLC cells was found ... -
Meme Kanseri Hücreleri Tarafından Üretilen Fibronektinin Miyeloid Hücre Karakteri Üzerine Etkisi
(Kanser Enstitüsü, 2019)Basal-like breast cancer (BLBC) possess high capacity to regulate inflammation and identified with high-level myeloid cell infiltration. Extracellular matrix components produced by tumor cells, e.g. fibronectin (FN), can ... -
Meme Kanseri Hücrelerinde Kostimülatör B7 Ailesi Ligandlarının Ekspresyonu ve Yardımcı T Hücre Yanıtları Üzerine Etkisi
(Kanser Enstitüsü, 2013)B7 ligands are the most critical costimulatory molecules that regulate T cell responses. Although these molecules are mainly expressed on professional antigen presenting cells, they may also be expressed on tumor cells. ... -
Meme Kanseri Hücrelerinde Pı-103 Inhibitörünün Aktive Reseptör Tirozin Kinaz Ekspresyonuna Etkisinin Incelenmesi
(Kanser Enstitüsü, 2014)Oncogenic activation of PI3K/Akt/mTOR signaling pathway is frequently seen in breast cancer. Inhibition of signaling pathway by PI3K inhibitors, tyrosine kinase inhibitors and/or monoclonal antibodies causes increase in ... -
Meme Kanseri Modelinde Myeloid Kökenli Hücrelerin Immün Kompartmanlardaki Dağılımının Anti-Tümör Yanıtlara Yansıması
(Kanser Enstitüsü, 2013)Myeloid cells of peripheral blood, bone marrow and spleens from NMU induced mammary tumor bearing Sprague-Dawley rats were examined in this study. Myeloid derived suppressor cells (MDSCs) in tumor bearing rats are defined ... -
Meme Kanserinde Göğüs Duvarı ve Lenfatik Işınlamada 3 Boyutlu Konformal Radyoterapi ile Yoğunluk Ayarlı Radyoterapi.
(Kanser Enstitüsü, 2013)Breast/chest wall (CW) and lymphatic irradiation for breast cancer is one of the most difficult techniques in radiotherapy. In this study, forward and inverse planing IMRT, hybrid IMRT plans were compared with the corresponding ... -
Meme Kanserinde, Il-1β ile Tetiklenen Epitelyal Mezenkimal Dönüşümde Hücre İskeleti Dinamiklerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023-03)The presence of interleukin (IL)-1β, a proinflammatory cytokine, has been demonstrated in the breast cancer microenvironment. IL-1β supports cell survival, proliferation, adhesion, invasion, and migration mechanisms. It ... -
Meme Kanserinde, Normal Fibroblastlar ve Kanserle İlişkili Fibroblastların Monosit Çağrılması, Makrofaj Polarizasyonu ve İnvazyona Etkisi
(Kanser Enstitüsü, 2018)GÖK YAVUZ B., The Effect of Cancer Associated Fibroblasts and Normal Fibroblasts on Monocyte Recruitment, Macrophage Polarization and Invasion in Breast Cancer. Hacettepe University Institute of Health Sciences Ph.D Thesis ...