Ara
Toplam kayıt 72, listelenen: 21-30
Determination of Lipid Metabolism Alterations and Their Association with Disease Pathogenesis in Sickle Cell Disease
(Sağlık Bilimleri Enstitüsü, 2020-07-07)
Sickle cell disease (SCD) is a hemoglobinopathy that causes severe anemia and is characterized by lipid abnormalities, oxidative stress and chronic inflammation. It is caused by a single point-mutation in the beta globin ...
Bisfenol A’nın Hepg2 Hücrelerine Olan Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2020)
Öz, E. Examination of the Effects of Bisphenol A on HepG2 Cells. Hacettepe
University Graduate School of Health Sciences, Biochemistry Program, Master
Thesis, Ankara, 2020. In this study, it was aimed to determine the ...
Improvement of Germ Stem Cell Pool by Leptin Supplementation and Gene Editing for Male Infertility
(Sağlık Bilimleri Enstitüsü, 2020-06-12)
Infertility affects up to 12-15% of sexually active couples, and male factors contribute about 30-55% of these cases. Infertility can be caused by injuries, genetic factors, exposure to toxicants, immune-suppressive and ...
Investigation of the Role of LAP1B in Transcriptional Regulation of Muscle Cells
(Sağlık Bilimleri Enstitüsü, 2021-01-20)
The loss-of-function of
the inner nuclear membrane protein LAP1B (lamina-associated polypeptide 1, isoform
B) causes muscular dystrophy and cardiomyopathy in humans. The function of LAP1B
in muscle is still unknown. The ...
Diyabet Hastalarında Mineral Trioksit Agregat/1α,25-Dihidroksivitamin D3 Kombinasyonu İle Dental Pulpa Kök Hücrelerinde Odontojenik Farklılaşmanın Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021-01-15)
Dental treatments in diabetic patients have been reported to fail in the long term and these patients have more tooth extraction. It is aimed to investigate the odonto/osteogenic differentiation potential of the combination ...
Kistik Fibrozis Patogenezinde Aday Mirna ve Hedef Genlerinin Biyoinformatik Araçlarla Tanımlanması
(Sağlık Bilimleri Enstitüsü, 2021)
Cystic fibrosis (CF) is a very common autosomal recessive genetic disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. Although disease severity is associated with the effect of mutations ...
Larinks Kanseri’nde Anjiyogenez, Proliferasyon, Hücre Adezyonu ve İnvazyonla İlişkili Biyobelirteçlerin Hastalık Özellikleri ile İlişkisinin Araştırılması
(Tıp Fakültesi, 2021)
Larynx squamous cell carcinoma (LSCC) is a
commonly seen subtype of head and neck cancer. Despite the advances in diagnosis
and treatment options through the years, there has been no improvement in the
survival rates ...
Desma Mutant Zebra Balığı Modelinde Tedavi Amaçlı Xmu-Mp-1 Uygulaması
(Sağlık Bilimleri Enstitüsü, 2021)
In this thesis, the application of XMU-MP-1 drug candidate molecule which is a MST1 / 2 kinase inhibitor and selectively inhibits the Hippo pathway was performed by mixing the drug with zebrafish embryo egg water or adult ...
Yeni Sentezlenen Antitirozinaz Aktiviteye Sahip Kojik Asit Türevlerinin A375 Malin Melanoma Hücre Hattında Sitotoksisite ve Hücre Ölümü Üzerine Etkisinin Aydınlatılması
(Tıp Fakültesi, 2021)
Felekoglu, R., The Effect of Kojic Acid Derivatives with New Synthesized
Antithyrosinase Activity on Cytotoxicity and Cell Death in the A375 Malign
Melanoma Cell Line, Hacettepe University Graduate School of Health ...
Spinal Müsküler Atrofi'li Drosophıla Melanogaster Modelinde Rpd3 Proteini ve Histon Asetilasyon Düzeylerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)
Histone acetylation causes relaxation of the DNA-histone interactions and transcriptional activation. It is controlled by the balance between histone acetyl transferase (HAT) enzymes which add acetyl groups to lysine amino ...