Familial Mediterranean Fever (FMF); is an autosomal recessively inherited autoinflammatory disease. FMF is caused by the mutations in the Mediterranean Fever (MEFV) gene which encodes the pyrin protein. The best treatment ...

Pediatric stroke is rare compared to adults, however causes long term morbidity and mortality. We retrospectively analysed children beyond newborn period, diagnosed with acute stroke and followed up at Hacettepe University ...

Kallikrein-kinin system(KKS) is a known mediator of vasogenic edema in patients with retinal vascular diseases. Although its effects are well characterized on vascular permeability and retinal thickness, the initiator of ...

KARIMISAKHVIDI, N., Investigation of the effect of melatonin administration on calpain-1 expression and atrophic morphology on atrophy of mouse Myoblast cell line exposed to hydrogen peroxide, Hacettepe Graduate School of ...

Drug repurposing approach is used to identify new indications of drugs outside the scope of their original indications. This approach has been used to identify effective compounds for neurodegenerative diseases. Axonal ...

Cystic fibrosis (CF) is the most common autosomal recessive genetic disorder of caucaisan population. Despite the multisystemic involvement in CF, increased mucus viscosity in the lungs, deterioration of mucociliary clearance ...

Autoinflammatory diseases, periodic fever syndromes, are a group of diseases that develop recurrent inflammatory response in the absence of infection. Familial Mediterranean fever, which is the most common disease among ...

Spinal muscular atrophy (SMA), which is characterized by motor neuron loss and muscle atrophy, is a neurodegenerative disease primarily in childhood. In SMA, Survival of motor neuron 1 (SMN1) gene mutations lead to the ...

The most common pathogens in urinary tract infections are E. coli, P. aeruginosa, K. pneumoniae. and A. baumannii. Therapy which is often empirical requires knowledge on local antibiotic resistance data. Therefore, it is ...