Bölüm "Tıbbi Biyokimya" Temel Tıp Bilimleri Bölümü Tez Koleksiyonu için listeleme
Toplam kayıt 14, listelenen: 1-14
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Antioksidan Kullanımının Meme Kanseri Tedavisi Üzerindeki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021-01-20)Drug resistance against chemotherapy is one of the main factors limitating the success of cancer treatment. Several studies have reported that the expression level of the glutathione S-transferase P1 (GSTP1) isozyme from ... -
Determination of Lipid Metabolism Alterations and Their Association with Disease Pathogenesis in Sickle Cell Disease
(Sağlık Bilimleri Enstitüsü, 2020-07-07)Sickle cell disease (SCD) is a hemoglobinopathy that causes severe anemia and is characterized by lipid abnormalities, oxidative stress and chronic inflammation. It is caused by a single point-mutation in the beta globin ... -
Hacettepe Üniversitesi Merkez Laboratuvarı Biyokimya Analizlerinde Onay Destek Sistemi Geliştirilmesi ve Validasyonu
(Tıp Fakültesi, 2020)The autoverification (AV) system in medical laboratories is a process in which computer-based algorithms automatically take actions on laboratory test results without the need for manual intervention by laboratory employees ... -
Investıgatıon of The In Vıtro And In Vıvo Effects of Telomere-Targeted New Drug Candıdate Compounds on Dıfferent Cancer Cell Lınes
(Sağlık Bilimleri Enstitüsü, 2023)Cancer, characterized by its heterogeneity, metastatic character, and limited treatability, stands as a leading global cause of mortality. Cancer cells elongate their telomeres through the activity of the telomerase enzyme, ... -
İnsan Serum Bütirilkolinesterazının Olası Lipolitik Aktivitesi-Lipid Metabolizması ile İlişkisi.
(Sağlık Bilimleri Enstitüsü, 2021-01-21)Cholinesterases (AChE and BChE) terminate acetylcholine-induced neurotransmission at cholinergic synapses in muscle-nerve junctions. We previously showed BChE expression is regulated by essential fatty acids. The similarity ... -
Karyojenik Bakterilerin Dental Pulpa Hücresinde Oluşturduğu Oksidatif Stresin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Caries-causing pathogenic microorganisms (cariogenic microorganisms) are the major source of pulpal inflammation and infection, and they cause the formation of reactive oxygen molecules (ROS) with the cell membrane components ... -
Kistik Fibrozis Hastalarının Alevlenme ve Remisyon Dönemleri Plazma Sfingomyelin ve Seramid Düzeylerinin Sıvı Kromatografisi-Kütle Spektrometresi ile Belirlenmesi ve Bazı İnflamasyon Belirteçleriyle İlişkisinin İncelenmesi
(Tıp Fakültesi, 2018)Cystic fibrosis (CF) is the most common autosomal recessive genetic disorder of caucaisan population. Despite the multisystemic involvement in CF, increased mucus viscosity in the lungs, deterioration of mucociliary clearance ... -
Klorofilinin Meme Kanseri Kaynaklı Metastaz Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)The development of drug resistance against chemotherapeutic agents is one of the main reasons for reducing the success of breast cancer treatment. It has been reported that the expression levels of Glutathione S-transferase ... -
Meme Kanserinde Sisplatin Hücresel Yanıtının DDB2 ve DNA Polimeraz Eta Üzerinden İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022)In this study, it was aimed to investigate the effect of administration of PNR-7-02 together with cisplatin to MCF-7 breast cancer cells on the expression of genes encoding DDB2 and DNA polymerase η proteins, which are ... -
Metakromatik Lökodistrofi Hastalığının Alt Tiplerinin Tanımlanması, Patojenik Mutasyonların Belirlenmesi, Patogenezde İnflamasyonun İncelenmesi
(Tıp Fakültesi, 2018)Pekgul, F., Identification of subtypes of metachromatic leukodystrophy, determination of pathogenic mutations, investigation of inflammation in pathogenesis, Hacettepe University Faculty of Medicine, Thesis in Medical ... -
Opioid kullanım bozukluğunda idrar ve tükürük numunelerinde yasaklı madde analizlerinin karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2023-01-20)Various drugs are used in the treatment of opioid use disorder (OUD). In the diagnosis and treatment of this group of patients, laboratory analyzes are required in order to detect the drugs used in the treatment as well ... -
Primer ve sekonder glioblastomların metabolomik yaklaşımla incelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Glioblastoma is the most common brain tumor in adults. Despite all treatments, the average survival is around 15 months. Glioblastoma includes primary and secondary subtypes that develop by different genetic pathways. In ... -
Trombositopenik Hastalarda Platelet Yüzey Antijenlerinin Akım Sitometri ile İncelenmesi ve Kanama Diyatezi ile İlişkisinin Araştırılması
(Tıp Fakültesi, 2019)Bleeding is mainly associated with low platelet counts and platelet dysfunctions. Although there are several methods to evaluate platelet function, they require large amount of blood and platelet counts more than 150.000/µl. ... -
Yeni Sentezlenen Antitirozinaz Aktiviteye Sahip Kojik Asit Türevlerinin A375 Malin Melanoma Hücre Hattında Sitotoksisite ve Hücre Ölümü Üzerine Etkisinin Aydınlatılması
(Tıp Fakültesi, 2021)Felekoglu, R., The Effect of Kojic Acid Derivatives with New Synthesized Antithyrosinase Activity on Cytotoxicity and Cell Death in the A375 Malign Melanoma Cell Line, Hacettepe University Graduate School of Health ...