Dosya Biçimi"Bilimsel Araştırma Projeleri KB" Temel Tıp Bilimleri Bölümü Tez Koleksiyonu için listeleme
Toplam kayıt 61, listelenen: 21-40
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Hücre Kültüründe Aromataz/Sirtuin-1 Etkileşiminin miRNA İfade Düzeyine Olan Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)Kartal, Y. Evaluation of the Relationship Between Aromatase/Sirtuin-1 Interaction and miRNA Expression in Human Neuroblastoma Cells, Hacettepe University Graduate School of Health Sciences Physiology Programme Doctor of ... -
Improvement of Germ Stem Cell Pool by Leptin Supplementation and Gene Editing for Male Infertility
(Sağlık Bilimleri Enstitüsü, 2020-06-12)Infertility affects up to 12-15% of sexually active couples, and male factors contribute about 30-55% of these cases. Infertility can be caused by injuries, genetic factors, exposure to toxicants, immune-suppressive and ... -
Investıgatıon of The In Vıtro And In Vıvo Effects of Telomere-Targeted New Drug Candıdate Compounds on Dıfferent Cancer Cell Lınes
(Sağlık Bilimleri Enstitüsü, 2023)Cancer, characterized by its heterogeneity, metastatic character, and limited treatability, stands as a leading global cause of mortality. Cancer cells elongate their telomeres through the activity of the telomerase enzyme, ... -
İlaç Yeniden Konumlandırma Yaklaşımı ile Alfa Tübülin Asetilasyonunu Arttırabilecek Bileşiklerin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Drug repurposing approach is used to identify new indications of drugs outside the scope of their original indications. This approach has been used to identify effective compounds for neurodegenerative diseases. Axonal ... -
İnsan Granüloza Hücresi Mitokondriyon Fonksiyonu ile AMH ve Östrojen İlişkisi
(Tıp Fakültesi, 2021)Anti-Müllerian Hormone (AMH) and estrogen are essential hormones in human ovarian folliculogenesis. AMH and estrogen are produced by granulosa cells. It is known that mitochondria in human granulosa cells are important for ... -
İnsan Serum Bütirilkolinesterazının Olası Lipolitik Aktivitesi-Lipid Metabolizması ile İlişkisi.
(Sağlık Bilimleri Enstitüsü, 2021-01-21)Cholinesterases (AChE and BChE) terminate acetylcholine-induced neurotransmission at cholinergic synapses in muscle-nerve junctions. We previously showed BChE expression is regulated by essential fatty acids. The similarity ... -
KAFEİN VE GLİKOZ TÜKETİMİNİN PREFRONTAL KORTEKS AKTİVİTESİ VE BİLİŞSEL PERFORMANS ÜZERİNE ETKİSİ
(Sağlık Bilimleri Enstitüsü, 2024-02-05)Caffeine is a psychoactive drug used to improve cognitive functions and is found in coffee, chocolate, various drinks and many medical treatments. Glucose is the most common dietary sugar in mammalian metabolism. Caffeine ... -
Kalıtsal Metabolik Hastalıklarda Otofaji, Oksidatif Stres ve İnflamasyon İlişkisi
(Sağlık Bilimleri Enstitüsü, 2023-08)The complications such as epilepsy, cataract, hepatic failure, chronic renal disease may develop during the clinical follow-up of the patients with inherited metabolic diseases. The aim of this study is to investigate the ... -
Kan Kültüründen İzole Edilen Acinetobacter Baumannii ve Pseudomonas Aeruginosa Suşlarında Karbapenem Heterodirencinin Fenotipik ve Moleküler Yöntemlerle Araştırılması
(Tıp Fakültesi, 2023)Since heteroresistance (HR) was first detected in Haemophilus influenzae in 1947, it has been described in many bacterial species and against different antibiotic classes. Briefly, HR is defined as the presence of bacterial ... -
Karyojenik Bakterilerin Dental Pulpa Hücresinde Oluşturduğu Oksidatif Stresin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Caries-causing pathogenic microorganisms (cariogenic microorganisms) are the major source of pulpal inflammation and infection, and they cause the formation of reactive oxygen molecules (ROS) with the cell membrane components ... -
Kistik Fibrozis Hastalarında Fenotipik Ciddiyeti Etkileyen Genlerin ve İlişkili Yolakların Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020-03-02)Cystic fibrosis, the most common autosomal recessive disease, is caused by mutations in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene. In addition to CFTR mutations, modifier genes and environmental factors play ... -
Kistik Fibrozis Patogenezinde Aday Mirna ve Hedef Genlerinin Biyoinformatik Araçlarla Tanımlanması
(Sağlık Bilimleri Enstitüsü, 2021)Cystic fibrosis (CF) is a very common autosomal recessive genetic disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. Although disease severity is associated with the effect of mutations ... -
Klinik Bacteroides fragilis Grubu İzolatlarda Enterotoksin ve Antibiyotik Direnç Genlerinin Prevalansı ve Moleküler Tiplendirme
(Tıp Fakültesi, 2023)Increasing rates of resistance to antibiotics used in the treatment of infections caused by Bacteroides fragilis group (BFG) isolates are reported worldwide. Surveillance is important as resistance profiles vary among ... -
Klinik Stenotrophomonas Maltophılıa İzolatlarında Kolistin Heterodirencinin Araştırılması
(Tıp Fakültesi, 2019)Liste U., Investigation of colistin heteroresistance in clinical Stenotrophomonas maltophilia isolates ,Hacettepe University Faculty of Medicine, Thesis In Medical Microbiology, Ankara, 2019. Stenotrophomonas maltophilia ... -
Klorofilinin Meme Kanseri Kaynaklı Metastaz Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)The development of drug resistance against chemotherapeutic agents is one of the main reasons for reducing the success of breast cancer treatment. It has been reported that the expression levels of Glutathione S-transferase ... -
Kolestaz Hastalarında Safra Asitlerinin Lc-Ms/Ms ile Araştırılması ve Olası Biyobelirteçlerin Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2020-02-18)Inborn errors of bile acid synthesis (IEBAS) are autosomal recessively inherited disorders that are resulted from the deficiencies in the structure or function of the enzymes involved in the synthesis of bile acids, causing ... -
L-arjinin ve Agmatinin İnsan NCI-H716 Hücrelerinde GLP-1 ve PYY Salgısı Üzerine Etkisi: Kalsiyum Algılayan Reseptörlerin Rolü
(Sağlık Bilimleri Enstitüsü, 2023-08-14)Agmatine is a natural polyamine produced from L-arginine by arginine decarboxylase and is abundant in foods. One of the most significant effects of glucagon like peptide-1 (GLP1) and peptide YY (PYY) hormones released ... -
Larinks Kanseri’nde Anjiyogenez, Proliferasyon, Hücre Adezyonu ve İnvazyonla İlişkili Biyobelirteçlerin Hastalık Özellikleri ile İlişkisinin Araştırılması
(Tıp Fakültesi, 2021)Larynx squamous cell carcinoma (LSCC) is a commonly seen subtype of head and neck cancer. Despite the advances in diagnosis and treatment options through the years, there has been no improvement in the survival rates ... -
Meme Kanserinde Sisplatin Hücresel Yanıtının DDB2 ve DNA Polimeraz Eta Üzerinden İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022)In this study, it was aimed to investigate the effect of administration of PNR-7-02 together with cisplatin to MCF-7 breast cancer cells on the expression of genes encoding DDB2 and DNA polymerase η proteins, which are ... -
Metakromatik Lökodistrofi Hastalığının Alt Tiplerinin Tanımlanması, Patojenik Mutasyonların Belirlenmesi, Patogenezde İnflamasyonun İncelenmesi
(Tıp Fakültesi, 2018)Pekgul, F., Identification of subtypes of metachromatic leukodystrophy, determination of pathogenic mutations, investigation of inflammation in pathogenesis, Hacettepe University Faculty of Medicine, Thesis in Medical ...