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The Impact Of Jak1/Jak2 Inhibitor Ruxolitinib On The Spleen Size And Symptom Burden In Myeloproliferative Diseases
(Akad Doktorlar Yayınevi, 2016)
Ruxolitinib as a JAK1 and JAK2 inhibitor drug has recently been approved for the treatment of patients with high-or intermediate-risk myelofibrosis with symptomatic splenomegaly. Clinical development of ruxolitinib has ...
The Impact Of Iron Overload On Transplant-Related Complications And Prognosis Of Acute Leukemias
(Akad Doktorlar Yayınevi, 2016)
The impacts of serum iron parameters and/or radiological evidence of systemic iron overload on the prognosis of hematopoietic stem cell transplantation (HSCT) in acute leukemia are controversial. Unfortunately, some of the ...
The Fourier Transform Infrared (Ftir) Spectroscopic and Mass Spectrometric Metabolomics Studies of Ankaferd Hemostat
(Akad Doktorlar Yayınevi, 2013)
Ankaferd is a traditional folkloric medicine that has been used in Anatolia as a hemostatic agent for centuries. Ankaferd Blood Stopper (ABS) is comprised of a standardized plant extracts of T. vulgaris, G. glabra, V. ...
Striking Promotion Of The In Vitro Myeloma Monoclonal Immunoglobulin Aggregation By Ankaferd Hemostat
(Akad Doktorlar Yayınevi, 2012)
Ankaferd Blood Stopper (ABS) is a novel topical hemostatic agent. ABS-induced formation of the protein network with vital erythroid aggregation covers the entire physiological hemostatic process. ABS has pleiotropic cellular, ...
The Clinical Impact of Low Doses of Dasatinib in Patients with Chronic Myeloid Leukemia
(Akad Doktorlar Yayınevi, 2012)
We report our experience in 41 patients with chronic phase (CF)-chronic myeloid leukemia (CML) who had discontinued imatinib switched to dasatinib, retrospectively. The CF-CML patients received dasatinib at starting dose ...
Iron Overload Pattern in Multiple Myeloma at Diagnosis Its Important Clinical Associations
(Akad Doktorlar Yayınevi, 2014)
As a plasmaproliferative disorder, multiple myeloma (MM) is not expected to cause IO and actually there are no reports on this condition in MM. In this retrospective study, we evaluated serum iron test results in MM patients ...
Idelalisib At The Crossroads Of B-Cell Lymphoproliferative Disorders
(Akad Doktorlar Yayınevi, 2016)
Phosphatidylinositol 3-kinases (PI3Ks) are considered as lipid kinases that are very active in the pathobiology of lymphoproliferative disorders (LPDs). Idelalisib, a selective inhibitor of the delta isoform of PI3K, ...
Molecular Management Of Chronic Lymphocytic Leukemia: Towards A Chemotherapy-Free Approach
(Akad Doktorlar Yayınevi, 2016)
B-cell receptor (BCR) signaling is implicated as a pivotal pathway in tumorigenesis in B-cell malignancies. The inhibitors of Bruton's tyrosine kinase (BTK) and phosphatidylinositide 3-kinase-delta (PI3K), modulating BCR ...
Bone Marrow Iron Staining Is a Reliable Test For Elimination of Iron Deficiency Anemia Rather Than Its Diagnosis
(Akad Doktorlar Yayınevi, 2013)
Iron deficiency anemia (IDA) is the most frequent type of anemia. The use of biochemical markers is a challenging way of diagnosis in case of inflammation and functional iron deficiency. The role of bone marrow aspirate ...
Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms In Leukemic Hematopoiesis
(Akad Doktorlar Yayınevi, 2011)
Local bone marrow renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin converting enzyme (ACE) converts angiotensinogen-I to its physiologically active ...