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The Mutational Spectrum Of Ptpn11 In Juvenile Myelomonocytic Leukemia And Noonan Syndrome/Myeloproliferative Disease
(Amer Soc Hematology, 2005)
Germ line PTPN11 mutations cause 50% of cases of Noonan syndrome (NS). Somatic mutations in PTPN11 occur in 35% of patients with de novo, nonsyndromic juvenile myelomonocytic leukemia (JIMML). Myeloproliferative disorders ...