• A European Organization for Research and Treatment of Cancer - International Antimicrobial Therapy Group Study of Secondary Infections in Febrile, Neutropenic Patients with Cancer 

      Akova, M; Paesmans, M; Calandra, T; Viscoli, C (Univ Chicago Press, 2005)
      Background. Neutropenic patients with cancer may develop several episodes of fever and infection during chemotherapy-induced myeloaplasia. Methods. To identify risk factors for secondary infectious episodes among patients ...
    • A Novel Mutation in the Interleukin-1 Receptor Antagonist Associated with Intrauterine Disease Onset 

      Altiok, Ender; Aksoy, Figen; Perk, Yildiz; Taylan, Fulya; Kim, Peter W.; Ilikkan, Barbaros; Asal, Gulten Turkkani; Goldbach-Mansky, Raphaela; Sanal, Ozden (Academic Press Inc Elsevier Science, 2012)
      Deficiency of the IL-1 receptor antagonist (DIRA) is a recently described rare autoinflammatory disease, caused by loss of function mutations in IL1RN leading to the unopposed activation of the IL-1 pathway. We describe a ...
    • A Phase II, Multicenter, Single-Arm Study to Evaluate the Safety and Efficacy of Deferasirox after Hematopoietic Stem Cell Transplantation in Children with Beta-Thalassemia Major 

      Yesilipek, Mehmet Akif; Karasu, Gulsun; Kaya, Zuhre; Kuskonmaz, Baris B.; Uygun, Vedat; Dag, Ilkiz; Ozudogru, Onur; Ertem, Mehmet (Elsevier Science Inc, 2018)
      We conducted a prospective, phase II, multicenter, single-arm study to evaluate the efficacy and safety of deferasirox in patients age >2 to <18 years with beta-thalassemia major (TM) who underwent hematopoietic stem cell ...
    • Acquisition of Meningococcal Serogroup W-135 Carriage in Turkish Hajj Pilgrims Who Had Received The Quadrivalent Meningococcal Polysaccharide Vaccine 

      Ceyhan, M.; Celik, M.; Demir, E. T.; Gurbuz, V.; Aycan, A. E.; Unal, S. (Amer Soc Microbiology, 2013)
      Invasive meningococcal disease is a recognized public health problem worldwide, with a dynamic and changeable epidemiology. In Turkey, the second most common pathogenic meningococcal serogroup (after serogroup B) is W-135, ...
    • Activity of Amoxicillin/Clavulanate in Patients with Tuberculosis 

      Chambers, HF; Kocagöz, T; Sipit, T; Turner, J; Hopewell, PC (Univ Chicago Press, 1998)
      Some beta-lactam antibiotics are active in vitro against Mycobacterium tuberculosis. There are anecdotal reports of successful treatment of tuberculosis caused by multiple-drug-resistant strains of M. tuberculosis with ...
    • Additional Diverse Findings Expand The Clinical Presentation of Dock8 Deficiency 

      Sanal, Özden; Jing, Huie; Ozgur, Tuba; Ayvaz, Deniz; Strauss-Albee, Dara M.; Ersoy-Evans, Sibel; Tezcan, Ilhan; Turkkani, Gulten; Matthews, Helen F.; Haliloglu, Goknur; Yuce, Aysel; Yalcin, Bilgehan; Gokoz, Ozay; Oguz, Kader K.; Su, Helen C. (Springer/Plenum Publishers, 2012)
      We describe seven Turkish children with DOCK8 deficiency who have not been previously reported. Three patients presented with typical features of recurrent or severe cutaneous viral infections, atopic dermatitis, and ...
    • Allelic Variants in Genes Associated with Hereditary Periodic Fever Syndromes as Susceptibility Factors for Reactive Systemic AA Amyloidosis 

      Aganna, E; Hawkins, PN; Ozen, Seza; Pettersson, T; Bybee, A; McKee, S; Lachmann, H; Karenko, L; Ranki, A; Bakkaloglu, A; Besbas, N; Topaloglu, R; Hoffman, H; Hitman, G; Woo, P; McDermott, M (Nature Publishing Group, 2004)
      We investigated the hypothesis that low-penetrance mutations in genes (TNFRSF1A, MEFV and NALP3/CIAS1) associated with hereditary periodic fever syndromes (HPFs) might be risk factors for AA amyloidosis among patients with ...
    • Allergen Immunotherapy For Allergic Asthma: A Systematic Review And Meta-Analysis 

      Dhami, S.; Kakourou, A.; Asamoah, F.; Agache, I.; Lau, S.; Jutel, M.; Muraro, A.; Roberts, G.; Akdis, C. A.; Bonini, M.; Cavkaytar, O.; Flood, B.; Gajdanowicz, P.; Izuhara, K.; Kalayci, O.; Mosges, R.; Palomares, O.; Pfaar, O.; Smolinska, S.; Sokolowska, M.; Asaria, M.; Netuveli, G.; Zaman, H.; Akhlaq, A.; Sheikh, A. (Wiley, 2017)
      BackgroundTo inform the development of the European Academy of Allergy and Clinical Immunology's (EAACI) Guidelines on Allergen Immunotherapy (AIT) for allergic asthma, we assessed the evidence on the effectiveness, ...
    • Allergic Rhinitis And Its Impact On Asthma (Aria): Achievements In 10 Years And Future Needs 

      Bousquet, J.; Schuenemann, H. J.; Samolinski, B.; Demoly, P.; Baena-Cagnani, C. E.; Bachert, C.; Bonini, S.; Boulet, L. P.; Bousquet, P. J.; Brozek, J. L.; Canonica, G. W.; Casale, T. B.; Cruz, A. A.; Fokkens, W. J.; Fonseca, J. A.; van Wijk, R. Gerth; Grouse, L.; Haahtela, T.; Khaltaev, N.; Kuna, P.; Lockey, R. F.; Carlsen, K. C. Lodrup; Mullol, J.; Naclerio, R.; O'Hehir, R. E.; Ohta, K.; Palkonen, S.; Papadopoulos, N. G.; Passalacqua, G.; Pawankar, R.; Price, D.; Ryan, D.; Simons, F. E. R.; Togias, A.; Williams, D.; Yorgancioglu, A.; Yusuf, O. M.; Aberer, W.; Adachi, M.; Agache, I.; Ait-Khaled, N.; Akdis, C. A.; Andrianarisoa, A.; Annesi-Maesano, I.; Ansotegui, I. J.; Baiardini, I.; Bateman, E. D.; Bedbrook, A.; Beghe, B.; Beji, M.; Bel, E. H.; Ben Kheder, A.; Bennoor, K. S.; Bergmann, K. C.; Berrissoul, F.; Bieber, T.; Jensen, C. Bindslev; Blaiss, M. S.; Boner, A. L.; Bouchard, J.; Braido, F.; Brightling, C. E.; Bush, A.; Caballero, F.; Calderon, M. A.; Calvo, M. A.; Camargos, P. A. M.; Caraballo, L. R.; Carlsen, K. H.; Carr, W.; Cepeda, A. M.; Cesario, A.; Chavannes, N. H.; Chen, Y. Z.; Chiriac, A. M.; Chivato Perez, T.; Chkhartishvili, E.; Ciprandi, G.; Costa, D. J.; Cox, L.; Custovic, A.; Dahl, R.; Darsow, U.; De Blay, F.; Deleanu, D.; Denburg, J. A.; Devillier, P.; Didi, T.; Dokic, D.; Dolen, W. K.; Douagui, H.; Dubakiene, R.; Durham, S. R.; Dykewicz, M. S.; El-Gamal, Y.; El-Meziane, A.; Emuzyte, R.; Fiocchi, A.; Fletcher, M.; Fukuda, T.; Gamkrelidze, A.; Gereda, J. E.; Gonzalez Diaz, S.; Gotua, M.; Guzman, M. A.; Hellings, P. W.; Hellquist-Dahl, B.; Horak, F.; Hourihane, J. O'B.; Howarth, P.; Humbert, M.; Ivancevich, J. C.; Jackson, C.; Just, J.; Kalayci, O.; Kaliner, M. A.; Kalyoncu, A. F.; Keil, T.; Keith, P. K.; Khayat, G.; Kim, Y. Y.; N'Goran, B. Koffi; Koppelman, G. H.; Kowalski, M. L.; Kull, I.; Kvedariene, V.; Larenas-Linnemann, D.; Le, L. T.; Lemiere, C.; Li, J.; Lieberman, P.; Lipworth, B.; Mahboub, B.; Makela, M. J.; Martin, F.; Marshall, G. D.; Martinez, F. D.; Masjedi, M. R.; Maurer, M.; Mavale-Manuel, S.; Mazon, A.; Melen, E.; Meltzer, E. O.; Mendez, N. H.; Merk, H.; Mihaltan, F.; Mohammad, Y.; Morais-Almeida, M.; Muraro, A.; Nafti, S.; Namazova-Baranova, L.; Nekam, K.; Neou, A.; Niggemann, B.; Nizankowska-Mogilnicka, E.; Nyembue, T. D.; Okamoto, Y.; Okubo, K.; Orru, M. P.; Ouedraogo, S.; Ozdemir, C.; Panzner, P.; Pali-Schoell, I.; Park, H. S.; Pigearias, B.; Pohl, W.; Popov, T. A.; Postma, D. S.; Potter, P.; Rabe, K. F.; Ratomaharo, J.; Reitamo, S.; Ring, J.; Roberts, R.; Rogala, B.; Romano, A.; Rodriguez, M. Roman; Rosado-Pinto, J.; Rosenwasser, L.; Rottem, M.; Sanchez-Borges, M.; Scadding, G. K.; Schmid-Grendelmeier, P.; Sheikh, A.; Sisul, J. C.; Sole, D.; Sooronbaev, T.; Spicak, V.; Spranger, O.; Stein, R. T.; Stoloff, S. W.; Sunyer, J.; Szczeklik, A.; Todo-Bom, A.; Toskala, E.; Tremblay, Y.; Valenta, R.; Valero, A. L.; Valeyre, D.; Valiulis, A.; Valovirta, E.; Van Cauwenberge, P.; Vandenplas, O.; van weel, C.; Vichyanond, P.; Viegi, G.; Wang, D. Y.; Wickman, M.; Woehrl, S.; Wright, J.; Yawn, B. P.; Yiallouros, P. K.; Zar, H. J.; Zernotti, M. E.; Zhong, N.; Zidarn, M.; Zuberbier, T. (Mosby-Elsevier, 2012)
      Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a ...
    • Allogeneic Hematopoietic Sct For Adults Aml Using I.V. Bu In The Conditioning Regimen: Outcomes And Risk Factors For The Occurrence Of Hepatic Sinusoidal Obstructive Syndrome 

      Nagler, A.; Labopin, M.; Berger, R.; Bunjes, D.; Campos, A.; Socie, G.; Kroeger, N.; Goker, H.; Yakoub-Agha, I.; Shimoni, A.; Mohty, M.; Rocha, V. (Nature Publishing Group, 2014)
      I.v. BU is frequently used in the conditioning regimen prior to allogeneic hematopoietic SCT (allo-HSCT); however, overall outcomes, incidence of hepatic sinusoidal obstructive syndrome (SOS) and its risk factors are not ...
    • Aseptic Abscess: A Report Of Two Cases 

      Isık, M.; Calguneri, M.; Dogan, I.; Yesilkaya, Y.; Shourbagi, A. (Biolife Sas, 2012)
      An aseptic abscess (AA) is an auto-inflammatory disorder characterized by necrotic lymph nodes and internal organ abscesses, most frequently located in the spleen. Described herein are two cases of aseptic abscesses; one ...
    • Bacterial Agents Causing Meningitis During 2013-2014 in Turkey: A Multi-Center Hospital-Based Prospective Surveillance Study 

      Ceyhan, Mehmet; Ozsurekci, Yasemin; Gürler, Nezahat; Öncel, Eda Karadağ; Camcıoglu, Yıldız; Salman, Nuran; Çelik, Melda; Emiroglu, Melike Keser; Akın, Fatih; Tezer, Hasan; Parlakay, Aslinur Ozkaya; Tuygun, Nilden; Tamburaci, Diyar; Dinleyici, Ener Cagri; Karbuz, Adem; Uluca, Unal; Alhan, Emre; Cay, Ummuhan; Kurugol, Zafer; Hatipoglu, Nevin; Siraneci, Rengin; Ince, Tolga; Sensoy, Gulnar; Belet, Nursen; Coskun, Enes; Yilmaz, Fatih; Hacimustafaoglu, Mustafa; Celebi, Solmaz; Celik, Umit; Ozen, Metehan; Akaslan, Aybuke; Devrim, Ilker; Kuyucu, Necdet; Oz, Fatmanur; Bozdemir, Sefika Elmas; Kara, Ahu (Taylor & Francis Inc, 2016)
      This is an observational epidemiological study to describe causes of bacterial meningitis among persons between 1 month and 18 y of age who are hospitalized with suspected bacterial meningitis in 7 Turkish regions. covering ...
    • Bacterial Infection Prevention After Hematopoietic Cell Transplantation 

      Engelhard, D.; Akova, M.; Boeckh, M. J.; Freifeld, A.; Sepkowitz, K.; Viscoli, C.; Wade, J.; Raad, I. (Nature Publishing Group, 2009)
    • Clinical Features Of Candidiasis In Patients With Inherited Interleukin 12 Receptor Beta 1 Deficiency 

      Ouederni, Monia; Sanal, Ozden; Ikinciogullari, Aydan; Tezcan, Ilhan; Dogu, Figen; Sologuren, Ithaisa; Pedraza-Sanchez, Sigifredo; Keser, Melike; Tanir, Gonul; Nieuwhof, Chris; Colino, Elena; Kumararatne, Dinakantha; Levy, Jacov; Kutukculer, Necil; Aytekin, Caner; Herrera-Ramos, Estefania; Bhatti, Micah; Karaca, Neslihan; Barbouche, Ridha; Broides, Arnon; Goudouris, Ekaterini; Luis Franco, Jose; Parvaneh, Nima; Reisli, Ismail; Strickler, Alexis; Shcherbina, Anna; Somer, Ayper; Segal, Anthony; Angel-Moreno, Alfonso; Luis Lezana-Fernandez, Jose; Bejaoui, Mohamed; Bobadilla-Del Valle, Miriam; Kachboura, Salem; Sentongo, Timothy; Ben-Mustapha, Imen; Bustamante, Jacinta; Picard, Capucine; Puel, Anne; Boisson-Dupuis, Stephanie; Abel, Laurent; Casanova, Jean-Laurent; Rodriguez-Gallego, Carlos (Oxford Univ Press, 2014)
      Background. Interleukin 12R beta 1 (IL-12R beta 1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin ...
    • Clinical Heterogeneity And Diagnostic Delay Of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome 

      Mazza, Cinzia; Buzi, Fabio; Ortolani, Federica; Vitali, Alberto; Notarangelo, Lucia D.; Weber, Giovanna; Bacchetta, Rosa; Soresina, Annarosa; Lougaris, Vassilios; Greggio, Nella A.; Taddio, Andrea; Pasic, Srdjan; de Vroede, Monique; Pac, Malgorzata; Kilic, Sara Sebnem; Ozden, Sanal; Rusconi, Roberto; Martino, Silvana; Capalbo, Donatella; Salerno, Mariacarolina; Pignata, Claudio; Radetti, Giorgio; Maggiore, Giuseppe; Plebani, Alessandro; Notarangelo, Luigi D.; Badolato, Raffaele (Academic Press Inc Elsevier Science, 2011)
      Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive organ-specific autoimmune disorder that is characterized by a variable combination of (i) chronic mucocutaneous candidiasis, ...
    • Cost Of Pneumococcal Infections And Cost-Effectiveness Analysis Of Pneumococcal Vaccination In At Risk Adults And Elderly In Turkey 

      Akin, Levent; Kaya, Mehmet; Altinel, Serdar; Durand, Laure (Landes Bioscience, 2011)
      Pneumococcal infections have a substantial burden in Turkey, particularly in the elderly (> 60 years) and at-risk adults (1859 years). VCR is low at approximately 2%. The first aim of this study was the evaluation of the ...
    • Cost-Effectiveness Of Rotavirus Vaccination In Turkey 

      Köksal, Tulin; Akelma, Ahmet Zulfikar; Koksal, Ali Osman; Kutukoglu, Irem; Ozdemir, Osman; Yuksel, Cigdem Nuket; Bozkaya, Davut; Catal, Ferhat; Sari, Sinan (Elsevier Taiwan, 2017)
      Background/Purpose: Cost-effectiveness studies about rotavirus (RV) vaccination programs were performed in many countries due to the severe economic burden of RV infections. This study is an economic evaluation performed ...
    • Dali: Defining Antibiotic Levels In Intensive Care Unit Patients: Are Current Beta-Lactam Antibiotic Doses Sufficient For Critically Ill Patients? 

      Roberts, Jason A.; Paul, Sanjoy K.; Akova, Murat; Bassetti, Matteo; De Waele, Jan J.; Dimopoulos, George; Kaukonen, Kirsi-Maija; Koulenti, Despoina; Martin, Claude; Montravers, Philippe; Rello, Jordi; Rhodes, Andrew; Starr, Therese; Wallis, Steven C.; Lipman, Jeffrey (Oxford Univ Press, 2014)
      Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether beta-lactam antibiotic dosing in critically ill patients achieves concentrations ...
    • Differential Biological Role Of Cd3 Chains Revealed By Human Immunodeficiencies 

      Recio, Maria J.; Moreno-Pelayo, Miguel Angel; Kilic, Sara S.; Guardo, Alberto C.; Sanal, Ozden; Allende, Luis M.; Perez-Flores, Veronica; Mencia, Angeles; Modamio-Hoybjor, Silvia; Seoane, Elena; Regueiro, Jose R. (Amer Assoc Immunologists, 2007)
      The biological role in vivo of the homologous CD3 gamma and delta invariant chains within the human TCR/CD3 complex is a matter of debate, as murine models do not recapitulate human immunodeficiencies. We have characterized, ...
    • Differential Roles Of Microglia And Monocytes In The Inflamed Central Nervous System 

      Yamasaki, Ryo; Lu, Haiyan; Butovsky, Oleg; Ohno, Nobuhiko; Rietsch, Anna M.; Cialic, Ron; Wu, Pauline M.; Doykan, Camille E.; Lin, Jessica; Cotleur, Anne C.; Kidd, Grahame; Zorlu, Musab M.; Sun, Nathan; Hu, Weiwei; Liu, LiPing; Lee, Jar-Chi; Taylor, Sarah E.; Uehlein, Lindsey; Dixon, Debra; Gu, Jinyu; Floruta, Crina M.; Zhu, Min; Charo, Israel F.; Weiner, Howard L.; Ransohoff, Richard M. (Rockefeller Univ Press, 2014)
      In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their numbers correlate to tissue damage. Macrophages may ...