• Reactivation of Camp Pathway by Pde4D Inhibition Represents A Novel Druggable Axis for Overcoming Tamoxifen Resistance in Er-Positive Breast Cancer 

      Mishra, Rasmi R.; Belder, Nevin; Ansari, Suhail A.; Kayhan, Merve; Bal, Hilal; Raza, Umar; Ersan, Pelin G.; Tokat, Unal M.; Eyupoglu, Erol; Saatci, Ozge; Jandaghi, Pouria; Wiemann, Stefan; Uner, Aysegul; Cekic, Caglar; Riazalhosseini, Yasser; Sahin, Ozgur (Amer Assoc Cancer Research, 2018)
      Purpose: Tamoxifen remains an important hormonal therapy for ER-positive breast cancer; however, development of resistance is a major obstacle in clinics. Here, we aimed to identify novel mechanisms of tamoxifen resistance ...
    • Wwox And Ap2 Gamma Expression Levels Predict Tamoxifen Response 

      Guler, Gulnur; Iliopoulos, Dimitrios; Guler, Nilufer; Himmetoglu, Cigdem; Hayran, Mutlu; Huebner, Kay (Amer Assoc Cancer Research, 2007)
      Purpose: Assessment of expression levels of Wwox, Wwox- interacting proteins Ap2 alpha, Ap2 gamma, and ErbB4, the Ap2 gamma transcriptional target protein Her2, and the possible Ap2 alpha transcriptional target Prka Rl ...