Bölüm "Tıbbi Farmakoloji" Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu için listeleme
Toplam kayıt 24, listelenen: 1-20
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5-Hydroxytryptamine Does Not Reduce Sympathetic Nerve Activity or Neuroeffector Function In The Splanchnic Circulation
(Elsevier Science Bv, 2015)Infusion of 5-hydroxytryptamine (5 HI) in conscious rats results in a sustained (up to 30 days) fall in blood pressure. This is accompanied by an increase in splanchnic blood flow. Because the splanchnic circulation is ... -
Aging Changes Agonist Induced Contractile Responses In Permeabilized Rat Bladder
(Springer, 2015)Aging alters bladder functions where a decrease in filling, storage and emptying is observed. These changes cause urinary incontinence, especially in women. The aim of this study is to examine how aging affects the ... -
Alpha(1)-Adrenoceptor-Mediated Contraction Of Rat Aorta Is Partly Mediated Via Transactivation Of The Epidermal Growth Factor Receptor
(Wiley-Blackwell, 2010)Background and purpose: High level of plasma catecholamines is a risk factor for vascular diseases such as hypertension and atherosclerosis. Catecholamines induce hypertrophy of vascular smooth muscle through alpha(1)-ad ... -
Automated Discrimination of Psychotropic Drugs in Mice Via Computer Vision-Based Analysis
(Elsevier Science Bv, 2009)We developed an inexpensive computer vision-based method utilizing an algorithm which differentiates drug-induced behavioral alterations. The mice were observed in an open-field arena and their activity was recorded for ... -
Bernard Lerer: Recipient of the 2014 Inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association For Clinical Pharmacogenetics)
(Mary Ann Liebert, Inc, 2014)This article announces the recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine by the Pacific Rim Association for Clinical Pharmacogenetics (PRACP): Bernard ... -
Decreased Activity And Genetic Polymorphisms Of Cyp2C19 In Behcet'S Disease
(Wiley, 2017)Behcet's disease (BD) is a systemic autoimmune disorder. Cytochrome P450 enzymes (CYPs) are responsible for various drug metabolism reactions as well as those of endogenous substances which may be associated with autoimmune ... -
Estrogen And Aging Affect Synaptic Distribution Of Phosphorylated Lim Kinase (Plimk) In Ca1 Region Of Female Rat Hippocampus
(Pergamon-Elsevier Science Ltd, 2008)17 beta-Estradiol (E) increases axospinous synapse density in the hippocampal CA1 region of young female rats, but not in aged rats. This may be linked to age-related alterations in signaling pathways activated by synaptic ... -
Evidence For Regulation Of Udp-Glucuronosyltransferase (Ugt) 1A1 Protein Expression And Activity Via Dna Methylation In Healthy Human Livers
(Wiley, 2013)Objectives Interindividual variability in glucuronidation of bilirubin and drugs by UDP-glucuronosyltransferase 1A1 (UGT1A1) is considerable and only partially explained by genetic polymorphisms and enzyme inducers. Here ... -
Hepatitis A Immunity In Yozgat, Turkey
(2019)BACKGROUND Since routine immunization could change the epidemiological profile of hepatitis A virus (HAV) infection in the future, it is important to determine the baseline immunity to HAV across Turkey. OBJECTIVE The aim ... -
Penetration of Topical, Oral, and Combined Administered Ofloxacin into the Subretinal Fluid
(Bmj Publishing Group, 1999)Aims-To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration. Methods-31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three ... -
Phorbol Esters Target the Activity-Dependent Recycling Pool and Spare Spontaneous Vesicle Recycling
(Soc Neuroscience, 2005)Using electrophysiology and styryl dye imaging, we studied the effect of phorbol 12-myristate 13-acetate ( PMA) on activity-dependent and spontaneous vesicle recycling. In electrophysiological experiments, we found that ... -
Risk Assessment and Communication Tools For Genotype Associations With Multifactorial Phenotypes: The Concept of "Edge Effect" And Cultivating an Ethical Bridge Between Omics Innovations and Society
(Mary Ann Liebert, Inc, 2009)Applications of omics technologies in the postgenomics era swiftly expanded from rare monogenic disorders to multifactorial common complex diseases, pharmacogenomics, and personalized medicine. Already, there are signposts ... -
Short-Term and Long-Term Fk506 Treatment Alters the Vascular Reactivity of Renal and Mesenteric Vascular Beds
(Japanese Pharmacological Soc, 2006)The aims of this study were to investigate the role of endothelin-1 in FK506-induced hypertension and vascular dysfunction of rats treated with the drug for 8 (short-term) or 30 (long-term) days and to measure malondialdehyde ... -
The Effects of Aspirin, Flurbiprofen, and No-Donating Acetylsalicylic Acid (Ncx 4016) on Mice Models of Endotoxic and Septic Shock
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: Nitric oxide-donating nonsteroidal antiinflammatory drugs (NO-NSAIDs) are a promising new class of antiinflammatory agents, which are obtained by adding NO-donating moieties to the existing conventional ...