Farklı Beden Kütle İndeksine Sahip Kadınların Beslenme Durumunun Bazı İnflamasyon Belirteçleri ile İlişkisinin Değerlendirilmesi
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This study aims to evaluate the relationship between nutritional status and some biochemical and inflammatory indicators in women aged 20-45 years and with varying body mass index (BMI). This study was carried out in Ankara Numune Education and Research Hospital. The study includes a case group of 40 women with BMI between 30.0-39.9 kg/m2 and a control group of 40 women, at similar ages, with healthy BMI. General informations, 3-days food records and same-day physical activities were recorded for the women included in the study. Anthropometric measurements, bioelectrical impedance analyses (BIA) and biochemical and inflammation parameters, blood pressure and diet quality index of the individuals were defined. The relationship between serum sCD14, LPS, LBP, TLR-4 and some parameters were analysed. A statistically significant difference was found in the mean values of serum iron, leukocyte, lymphocyte, neutrophil, fibrinogen, vitamin D, LDL-cholesterol, triglyceride, IL-6, TNF-α and hsCRP levels between the groups (p<0.05). No significant difference was found in terms of fasting serum glucose, HDL-cholesterol, ferritin, sCD14, LPS, LBP and TLR-4 levels between the groups (p>0.05). Serum iron and vitamin D levels were lower in the case group than in the control group (p<0.05). The serum urine, triglyceride, total cholesterol, LDL-cholesterol, unsaturated iron binding capacity, WBC, LYM, NE, fibrinogen, free T3, insulin, HOMA-IR, IL-6, TNF-α and hsCRP levels were higher than the control group of the case group (p<0.05). The case group achieved a suboptimal Diet Quality Index (DQI) score. Wherase the control group achieved an average score (p<0.05). Daily dietary energy intake and the total percentage of energy from carbohydrate were higher in the case group, whereas the control group had acquired more of its energy from fats (p<0.05). The total percentage of energy from protein is similar for both groups (p>0.05). A low-level, negative and significant correlation was found between serum sCD14 and neck circumference, serum LDL cholesterol (r=-0.342, p<0.05 and r=-0.419, p<0.05, respectively) in the control group, and between serum ferritin and n-6 intake in the case group (r=-0.322, p<0.05 and r=-0.360, p<0.05, respectively). A low-level and positive (r=0.339, p<0.05) relationship was found between control group dietary cholesterol intake and serum LPS, whereas a low-level, negative and significant correlation was found between water-insoluble fiber and serum LPS in the case group (r=-0.361, p<0.05). A negative and significant correlation was found between serum sCD14, LPS, LBP, TLR-4 and DQI score in the case and control groups. Changing lifestyle and reduction of inflammation plays a crucial role in obesity treatment. To improve and protect health, a personalized diet should be prepared, optimized and monitored.