Kanda Sfingosin-1-Fosfat Düzeyi ve Endometrioma İlişkisi

Abstract

Mammadova S, S1P blood level and Endometrioma relation. The overall prevalence of endometriosis in reproductive age patients is 3-10%. Endometriosis is diagnosed by histologic examination of ectopic endometrial gland and stroma but this method is invasive. Therefore, many markers for endometriosis have been investigated, but none have been an alternative to laparoscopy. Sphingosine-1-phosphate is a bioactive lipid. Yapılan çalışmalarda daha çok S1P malign hastalıklardaki angiogenetik özelliklerınin üzerinde durulmaktadır. In endometrial cells, the rate of proliferation is similar to that of malignant diseases and the apoptotic sensitivity is decreased. Therefore, it is thought that patients with endometriosis may be a useful diagnostic marker for non-invasive diagnosis of S1P endometriosis. In this study, we aimed to investigate whether there is correlation between sphingosine-1 phosphate level and disease in patients with endometrioma and we think that S1P may be used in the future for the non-invasive diagnosis of endometriosis. Thirty patients who were diagnosed with endometriomas greater than 3 cm and who met the criteria of the study were admitted to the outpatient clinic of Hacettepe University Faculty of Medicine, Department of Obstetrics and Gynecology between December 2016 and March 2017 for 30 cases Control group. The mean age of the patients was similar in both groups. There was no statistically significant difference between groups in terms of S1P value (P = 0.8). There was no statistically significant difference between groups in terms of AMH value (P = 0.2). The mean value of CA125 value between the groups was calculated as 32.3 ± 28 U / mL in the endometrioma group and 18.8 ± 22.1 U / mL in the control group and statistically significant difference was found (P = 0.002). The number of AFCs in the study group was 8.6 ± 5.9 in the endometrioma group and 16.4 ± 12.2 in the control group and statistically significant difference was found (p = 0.01). There was no statistically significant difference between the groups in terms of VKI (p> 0.05). There was no statistically significant difference between cyst diameter and S1P in single analysis (p> 0,05). Variables that did not independently affect S1P level were determined as age, infertility, AFC count, VKI, AMH, CA125, disease duration and when evaluated together with these factors, it was determined that cyst size affects S1P level in endometriated patients and statistically significant difference was found (p = 0,03