Başlık için Temel Eczacılık Bilimleri Bölümü listeleme
Toplam kayıt 188, listelenen: 132-151
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Nanoteknolojinin Farmasötik Uygulamalarda Kullanımının ve Nanopartiküllerin Toksik Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2021-12)ACAR, E. H., Evaluation of the Use of Nanotechnology in Pharmaceutical Applications and the Toxic Effects of Nanoparticles, Hacettepe University Graduate School Health Sciences Pharmacy Department of Pharmaceutical Toxicology ... -
Neurotoxic Effects Of Bisphenol A On Sh-Sy5Y Neuroblastoma Cells Via Nitric Oxide
(2019)Bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl)propane)polycarbonate is an industrial component frequently used as an additive in the construction of epoxy resin and other non-polymer plastics. In this study cytotoxicity of low ... -
Nnav1.5 Sodyum Kanalı ve Noç-4 Reseptör Sinyalinin Baskılanmasının İnsan Meme Kanseri Hücrelerinde Çoğalma ve Metastatik Potansiye Üzerine Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2013)The incidence of breast cancer is rapidly increasing and it is one of the major causes of death. The molecular changes leading to malignant transformation and metastasis of mammary cells is studied intensively. The expression ... -
Non-Enzymatic Electrochemical Sensing Of Malathion Pesticide In Tomato And Apple Samples Based On Gold Nanoparticles-Chitosan-Ionic Liquid Hybrid Nanocomposite
(2018)Malathion (MLT) is an organophosphorous type pesticide and having seriously high toxicity and electrochemical platforms for rapid, simple, inexpensive and sensitive determination of pesticides is still a special concern. ... -
Nonsteroidal Antiinflarmatur İlaçların Toksikolojisi
(Hacettepe Üniversitesi, 2010)Zehirlenmeler yetişkin ve çocuk acil servisleri başta olmak üzere sık karşılaşılan klinik durumlardan biridir. Zehirlenme tedavisinde zamanında ve uygun müdahalenin önemi büyüktür. Zehirlenmeler içerisinde ilaca bağlı ... -
Nucleotide Excision Repair By Dual Incisions In Plants
(Natl Acad Sciences, 2016)Plants use light for photosynthesis and for various signaling purposes. The UV wavelengths in sunlight also introduce DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts ... -
Optimization Of A Gas Chromatography-Mass Spectrometry Method Using Chemometric Techniques For The Determination Of Ezetimibe In Human Plasma
(Scientific Technical Research Council Turkey-Tubitak, 2013)A new, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed for the determination of ezetimibe (EZE) in human plasma. EZE was derivatized prior to GC-MS analysis. Various derivatization ... -
Organik Stereokimya
(Hacettepe Üniversitesi Yayınları, 2014)Stereokimya, farklı bir bilim değil kimya biliminin bir alt alanıdır. Bu alan organik kimya kitaplarında oldukça uygun bir biçimde ayrı bir bölüm olarak bulunmaktadır. Stereokimya, organik kimya içinden doğduğu ve organik ... -
Organosfatlara Maruziyet Sonrasında Oluşan Protein Eklenti Ürünlerini Tanıyan Monoklonal Antikorun Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2018)Organophosphorus (OP) pesticides are irreversible inhibitors of cholinesterases [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)]. The OPs cause the acute toxic effect by covalent binding to a serine amino ... -
Örneklerle Organik Kimya Nomenklatürü
(Hacettepe Üniversitesi, 2008)Bilimsel yaşamımız ve eğitimimizin en önemli sorunlardan birisi Türkçe kitap eksikliğidir. Nomenklatür konusundaki bu eksikliği gidermek amacı ile 1995 yılında "Organik Kimya Nomenklatürü" isimli kitabımızı yayınlamıştık. ... -
Özgün Heterosiklik Bileşiklerin Glutatyon Transferaz P1-1 İnhibitörleri Olarak Araştırılması ve İnsan Meme Kanser Hücreleri Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2012)The aim of this project is to design inhibitors for GST P1-1 and test their effectiveness on breast cancer cells. For this purpose benzoxazole, benzimidazole, benzothiazole derivative compounds were synthesized. Recombinant ... -
P-31 Nmr Correlation Maps Of O-18/O-16 Chemical Shift Isotopic Effects For Phosphometabolite Labeling Studies
(Springer, 2011)Intramolecular correlations among the O-18-labels of metabolic oligophosphates, mapped by J-decoupled P-31 NMR 2D chemical shift correlation spectroscopy, impart stringent constraints to the O-18-isotope distributions over ... -
Parasetamolün Parenteral Çözeltide Stabilite Göstergeli Miktar Tayini İçin Yüksek Performanslı Sıvı Kromatografisi Yöntemi Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2022-09-20)The analytical validation of the parenteral solution in the semi-permeable primary bag and the non-permeable primary vial packaging containing the active ingredient Paracetamol was completed by developing a stability ... -
Plasma 8-Isopgf2 Alpha and Serum Melatonin Levels in Patients with Minimal Cognitive Impairment and Alzheimer Disease
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: F2 alpha-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with ... -
Poly-(L)-Histidine Immobilized Cryogels for Lysozyme Purification
(Sage Publications Inc, 2016)Immobilized metal ion affinity chromatography is one of the methods used for the adsorption of proteins. In this study, poly(glycidyl methacrylate) cryogel discs were prepared by free radical polymerization. The metal ... -
Polyproline Tetramer Organizing Peptides in Fetal Bovine Serum Acetylcholinesterase
(Elsevier Science Bv, 2013)Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was ... -
Proguanil Metabolism in Relation To S-Mephenytoin Oxidation in A Turkish Population
(Blackwell Science Ltd, 1996)The oxidation of proguanil was studied in 89 unrelated healthy Turkish volunteers after administration of proguanil (single dose, 200 mg, orally). Based on the distribution of the ratio of proguanil to cycloguanil excreted ... -
Raloksifen'in Biyolojik Materyalden ve Farmasötik Preparattan Analizi İçin Gaz Kromatografisi-Kütle Spektrometrisi Yönteminin Geliştirilmesi ve Valide Edilmesi
(Sağlık Bilimleri Enstitüsü, 2012)Raloxifene is selective estrogen modulator (SERM) drug which is used in the treatment of postmenopausal osteoporosis in women and used for doping in men. A new gas chromatography-mass spectrometry (GC-MS) method was developed ... -
Regeneration and Healing of Bone and Cartilage in Type-1 and Type-2 Diabetes: The Effects of Insulin
(Tubitak Scientific & Technical Research Council Turkey, 2016)Increased fragility of long bones and delay in fracture healing in adults as well as skeletal development disorders in children are thought to be associated with endochondral ossification problems. The extracellular matrix ...