Başlık için Temel Eczacılık Bilimleri Bölümü listeleme
Toplam kayıt 188, listelenen: 99-118
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Karaciğer ve Meme Kanseri Hücreleri ile Embriyonik Böbrek Hücrelerinde Doksorubisinin Apoptotik Genlerin ve Mdr-1 Geninin Ekspresyon Düzeylerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2013)In this study, in order to investigate roles of certain genes and expression levels of these genes in apoptosis, MCF-7 (breast), HEPG2 (liver) cancer cells and HEK293 embryonic kidney cells were treated with increasing ... -
Kardiyopulmoner Baypas Sonrası Gelişen Akut Böbrek Yetmezliğinin Erken Tanısı İçin Omiks Yaklaşımlar ve Elektroanalitik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2022-09-09)Patients exposed to cardiopulmonary bypass may develop acute renal failure (ARF) as a result of blood coming into contact with the heart-lung machine circuits. The serum creatinine level is checked for the diagnosis of ... -
Kimyasal Olarak İndüklenmiş Meme Kanseri Modelinde Klorofilin-Cu Kompleksinin Antioksidan Etkinliğinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2015)Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Investigation show that glutathione and related enzymes are often overexpressed in tumor cells ... -
Kojic Acid Derivatives As Potential Anticancer Agents: Synthesis And Cytotoxic Evaluation On A375 Human Malignant Melanoma Cells
(2019)Malignant melanoma is a serious type of skin cancer with high mortality rates, arising from melanocytic cells responsible for the pigmentation of the skin. Besides, the excessive accumulation of melanin pigment can lead ... -
Kolon Kanserinin Tedavisinde Fenotiyazin Yapılı Bileşiklerin Kullanımlarının Değerlendirilmesi ve Etki Mekanizmalarının Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022-07). Epidemiological studies associate cancer and neurodegenerative diseases with each other. Amyloid precursor protein (APP), which is closely related to Alzheimer's disease, attracts attention in cancer research. Recent ... -
Kuzey Kıbrıs Türk Cumhuriyeti’nde Tüketilen Süt Örneklerinde Aflatoksin M1 Düzeylerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)AFM1 is the hydroxylated metabolite of AFB1, and it is formed in the liver by cytochrome P450 enzymes and can be secreted into the urine, feces and milk of mammals. Since AFM1 is a carcinogenic, cytotoxic, teratogenic, ... -
Lactoferrin In Gingival Crevicular Fluid And Peripheral Blood During Experimental Gingivitis
(2009)Objectives Lactoferrin (LF) is an iron binding protein and stored in the specific granules of granulocytes. It is released by degranulation following granulocyte activation. A positive correlation was previously reported ... -
Leflunomid In Farmasötik Preparatlardan Analizi Için Kapiler Elektroforez Yöntemi Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2013)In this study, a new micellar electrokinetic capillary chromatography (MEKC) method was developed to analysis of Leflunomide in pharmaceutical preparations. Best results in the MEKC method were obtained by the use of pH ... -
Long-Term Effects Of Early-Life Antibiotic Exposure On Resistance To Subsequent Bacterial Infection
(2019)The gastrointestinal microbiota protects hosts from enteric infections; while antibiotics, by altering the microbiota, may diminish this protection. We show that after early-life exposure to antibiotics host susceptibility ... -
Low-Dose Bisphenol A Induces Ripk1-Mediated Necroptosis In Sh-Sy5Y Cells: Effects On Tnf-Alpha And Acetylcholinesterase
(2019)Bisphenol A (BPA) is an endocrine disruptor chemical, which is commonly used in everyday products. Adverse effects of its exposure are reported even at picomolar doses. Effects of picomolar and nanomolar concentrations of ... -
Lökosit Miyeloperoksidaz Enziminin Saflaştırılması, Kinetik Özellikleri ile Reaktif Türlerin Oluşumundaki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)Myeloperoxidase (MPO) has been purified from human leucocytes obtained by leukapheresis, and kinetic properties were determined, nitrite oxidation and tyrosine nitration catalyzed by the purified enzyme have been studied. ... -
Melaleuca Alternifolia (Çay Ağacı) Yağının Kozmetiklerdeki Güvenliliğinin ve Olası Toksisitesinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2021)Essential oils have been used in cosmetic products for centuries. Its use for many years can be perceived as a reassuring factor; however, some of these oils can be dangerous for consumers through transdermal absorption ... -
Meme Kanserinde Hedeflenmiş Metabolitlerin LC-MS/MS Yöntemi ile Tayinleri
(Sağlık Bilimleri Enstitüsü, 2019)The best preventive method for breast cancer, which accounts for 18% of the most common cancer-related deaths among women, is the early diagnosis. Metabolomic analyzes have an important role in early diagnosis and tracking ... -
Metabolomik Ve Fluksomik Çalışmalar ile Kolon Kanserinde Kemoterapötiklere Karşı Direncin in Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019-06-25)Özen G., In Vitro Analysis of Resistance to Chemotherapeutics in Colon Cancer by Metabolomic and Fluxomic Studies, Hacettepe University Graduate of Health Sciences, Analytical Chemistry Program, Ph.D. Thesis, Ankara, 2019. ... -
Metastatik Meme Kanseri Hücrelerinde Mtor Üzerine Etkili Bazı Mekanizmaların Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)Signal trunsduction pathways play crucial roles in breast cancer pathogenesis. mTOR, which plays a central role in cell proliferation and interacts with several cell components, is selected as a target in MDA-MB- 231 ... -
Methamidophos, Dichlorvos, O-Methoate And Diazinon Pesticides Used In Turkey Make A Covalent Bond With Butyrylcholinesterase Detected By Mass Spectrometry
(Wiley, 2010)Organophosphorus pesticides used most commonly in Turkey include methamidophos, dichlorvos, O-methoate and diazinon. These toxic chemicals or their metabolites make a covalent bond with the active site serine of ... -
Misincorporation Of Free M-Tyrosine Cytotoxic Mechanism For Oxidized A Into Cellular Proteins: A Potential Amino Acids
(Portland Press Ltd, 2006)In vitro studies demonstrate that the hydroxyl radical converts L-phenylalanine into in-tyrosine, an unnatural isomer of L-tyrosine. Quantification of m-tyrosine has been widely used as an index of oxidative damage in ... -
Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline In Multiple Animal Models Of Familial Alzheimer'S Disease
(2015)Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau ...