Başlık için Temel Eczacılık Bilimleri Bölümü listeleme
Toplam kayıt 188, listelenen: 86-105
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In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
(Wiley, 2008)HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ... -
In Vivo Inhibition Of Lung Cancer By Grn163L: A Novel Human Telomerase Inhibitor
(Amer Assoc Cancer Research, 2005)Differential regulation of telomerase activity in normal and tumor cells provides a rationale for the design of new classes of telomerase inhibitors. The telomerase enzyme complex presents multiple potential sites for the ... -
Increased Levels Of Nitric Oxide, Cortisol And Adrenomedullin In Patients With Chronic Schizophrenia
(Karger, 2007)Objective: To investigate the levels of serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), nitric oxide (NO) and adrenomedullin (AM) in schizophrenic patients. Subjects and Methods: Sixty-six male patients with chronic ... -
Indian Saffron - Turmeric (Curcuma Longa) Embedded Supermacroporous Cryogel Discs For Heavy Metal Removal
(2019)Cryogels are used in a variety of environmental and biotechnological processes. Cryogels are polymeric materials with large pores and open flow channels. Turmeric is a very popular spice, especially in India, which has ... -
Induction Of Telomere Dysfunction Mediated By The Telomerase Substrate Precursor 6-Thio-2'-Deoxyguanosine
(Amer Assoc Cancer Research, 2015)The relationships between telomerase and telomeres represent attractive targets for new anticancer agents. Here, we report that the nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG) is recognized by telomerase and ... -
Investigating the Structural Influence of Surface Mutations on Acetylcholinesterase Inhibition by Organophosphorus Compounds and Oxime Reactivation
(Elsevier Ireland Ltd, 2010)Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have ... -
Investigation Of Gelatinase Gene Expression And Growth Of Enterococcus Faecalis Clinical Isolates In Biofilm Models
(2019)Objectives: Enterococcus faecalis is the major reason for biofilm-related infections and it also interacts with Staphylococcus aureus in biofilms. Gelatinase (gelE) enzyme is an important virulence factor of E. faecalis ... -
Islamic Fasting Leads To An Increased Abundance Of Akkermansia Muciniphila And Bacteroides Fragilis Group: A Preliminary Study On Intermittent Fasting
(2019)Background/Aims It has been largely accepted that dietary habits affect intestinal microbiota composition. In this pilot study, we hypothesized that time-restricted feeding, which can be regarded as a type of intermittent ... -
İnsan Serum Bütirilkolinesterazı ve Eritrosit Asetilkolinesterazının Statin Türevleri ile Etkileşiminin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2014)To investigate effects of statins on cholinesterases, Butyrylcholinesterase (BChE; E.C.3.1.1.8 ) was purified from human plasma through acid dialysis, DEAE-Tris Acryl M ion exchange and Procainamide-Sepharose 4B chromatography ... -
İnsan Serum Bütirilkolinesterazının Karaciğer Hepg2 Hücrelerinde Lipid Metabolizması ile Etkileşiminin İncelenmesi.
(Sağlık Bilimleri Enstitüsü, 2015)Butyrylcholinesterase (BChE) synthesized in liver is mostly associated with the detoxification of xenobiotics. Recently we have shown that in sedentary young males, application of exercise and/or conjugated linoleic acid ... -
İşle İlişkili Astım ve Silikozis Tanılı Hastalarda Oksidatif Stres Parametrelerinin ve Genotoksik Etkilerin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022)Asthma is a global health problem that affects more than 300 million people in the world. About 10-33% of adult-onset asthma is work-related asthma (WRA). Silicosis is an occupational lung disease that can result in the ... -
Karaciğer ve Meme Kanseri Hücreleri ile Embriyonik Böbrek Hücrelerinde Doksorubisinin Apoptotik Genlerin ve Mdr-1 Geninin Ekspresyon Düzeylerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2013)In this study, in order to investigate roles of certain genes and expression levels of these genes in apoptosis, MCF-7 (breast), HEPG2 (liver) cancer cells and HEK293 embryonic kidney cells were treated with increasing ... -
Kardiyopulmoner Baypas Sonrası Gelişen Akut Böbrek Yetmezliğinin Erken Tanısı İçin Omiks Yaklaşımlar ve Elektroanalitik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2022-09-09)Patients exposed to cardiopulmonary bypass may develop acute renal failure (ARF) as a result of blood coming into contact with the heart-lung machine circuits. The serum creatinine level is checked for the diagnosis of ... -
Kimyasal Olarak İndüklenmiş Meme Kanseri Modelinde Klorofilin-Cu Kompleksinin Antioksidan Etkinliğinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2015)Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Investigation show that glutathione and related enzymes are often overexpressed in tumor cells ... -
Kojic Acid Derivatives As Potential Anticancer Agents: Synthesis And Cytotoxic Evaluation On A375 Human Malignant Melanoma Cells
(2019)Malignant melanoma is a serious type of skin cancer with high mortality rates, arising from melanocytic cells responsible for the pigmentation of the skin. Besides, the excessive accumulation of melanin pigment can lead ... -
Kolon Kanserinin Tedavisinde Fenotiyazin Yapılı Bileşiklerin Kullanımlarının Değerlendirilmesi ve Etki Mekanizmalarının Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022-07). Epidemiological studies associate cancer and neurodegenerative diseases with each other. Amyloid precursor protein (APP), which is closely related to Alzheimer's disease, attracts attention in cancer research. Recent ... -
Kuzey Kıbrıs Türk Cumhuriyeti’nde Tüketilen Süt Örneklerinde Aflatoksin M1 Düzeylerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)AFM1 is the hydroxylated metabolite of AFB1, and it is formed in the liver by cytochrome P450 enzymes and can be secreted into the urine, feces and milk of mammals. Since AFM1 is a carcinogenic, cytotoxic, teratogenic, ... -
Lactoferrin In Gingival Crevicular Fluid And Peripheral Blood During Experimental Gingivitis
(2009)Objectives Lactoferrin (LF) is an iron binding protein and stored in the specific granules of granulocytes. It is released by degranulation following granulocyte activation. A positive correlation was previously reported ...