Takayasu Arteriti Hastalarında Antifosfolipid Antikor ve Lupus Antikoagülan Pozitifliğiyle Vasküler Tutulum Şiddetinin Değerlendirilmesi

Abstract

Fırat, E. The Evaluation of asssociation between antiphospholipid antibodies or lupus anticoagulant positivity and severity of vascular involvement in Takaysu arteritis patients Hacettepe University Faculty of Medicine, Thesis in Internal Medicine Departmant, Ankara, 2016. This study was planned to find out the prevelance of immunoglobulin IgM/G anti-cardiolipin antibodies, anti beta 2 glycoprotein- 1antibodies and lupus anticogulant in Takayasu Arteritis patients and evaluate the relationship between these antib odies and disease severity/complications in Takayasu arteritis patients. 53 patients with Takayasu arteritis patients were enrolled in this study. We obtained blood samples to detect IgM/G anti-cardiolipin antibodies, anti beta 2 glycoprotein 1antibodies and lupus anticogulant (LA) levels from all patients during their routine control. Immunoglobulin IgM/G anti-cardiolipin antibody, anti beta 2 glycoprotein 1antibodies were measured by using a standardized enzyme-linked immunosorbent assay (ELISA) and lupus anticogulant was measured using the dilute Russell’s viper venom time (dRVVT). No one was positive for IgM/G anti-cardiolipin antibody. Seven were pozisitive immunoglobulin IgM anti beta 2 glycoprotein 1antibodies, three were pozisitive immunoglobulin IgG anti beta 2 glycoprotein 1 antibodies, one was positive LA. All of the antibody titters were low. TA patients who had antibody positivity has longer disease duration (p<0,05). Antibody and LA positive patients had more superior mesenteric artery and Celiac artery involvement then the antibody negative patients (p<0,05). In this study that there were no association between the antibodies positivity and vascular involvement or disease complications or disease severity in TA patients. In conclusion we can not recommed the routine evaluation of antiphospholipid antibodies or lupus anticoagulant test during the follow-up Takayasu artritis patients. These antibosies may only be measured in the presence of clinical suspicion. Key words: Takayasu arteritis, anti beta 2 glycoprotein 1antibodies, G anti-cardiolipin antibody, lupus anticogulant, antiphospholipid antibody syndrome