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Toplam kayıt 13, listelenen: 1-10
Determination Of Regional Intestinal Permeability Of Diclofenac And Metoprolol Using A Newly-Developed And Validated High Performance Liquid Chromatographic Method
(Pharmacotherapy Group, 2015)
Purpose: To develop a simple and rapid reversed-phase high performance liquid chromatographic (HPLC) method with UV detection for the simultaneous determination of diclofenac, metoprolol tartrate, phenol red and propyl ...
The Operational Multiple Dosing Half-Life: A Key To Defining Drug Accumulation In Patients And To Designing Extended Release Dosage Forms
(Springer/Plenum Publishers, 2008)
Half-life (t (1/2)) is the oldest but least well understood pharmacokinetic parameter, because most definitions are related to hypothetical 1-compartment body models that don't describe most drugs in humans. Alternatively, ...
Comparison Of Dissolution Profiles Of Commercially Available Lamivudine Tablets
(Dissolution Technologies, Inc, 2015)
The aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three ...
Design And Characterization Of Nanocrystal Formulations Containing Ezetimibe
(Pharmaceutical Soc Japan, 2011)
Ezetimibe is a lipid-lowering compound that selectively inhibits the absorption of cholesterol and related phytosterols from the intestine As ezetimibe is almost Insoluble in water, its bioavailability is too low to be ...
Thrombus Localization By Using Streptokinase Containing Vesicular Systems
(Taylor & Francis Ltd, 2006)
Our research focused on the preparation of vesicular drug delivery systems, such as liposomes, noisomes, and sphingosomes, for achieving slow release of entrapped proteins in the circulation to increase half-life, to mask ...
Development Of A Peptide-Containing Chewing Gum As A Sustained Release Antiplaque Antimicrobial Delivery System
(Springer, 2007)
The objective of this study was to characterize the stability of KSL-W, an antimicrobial decapeptide shown to inhibit the growth of oral bacterial strains associated with caries development and plaque formation, and its ...
A Quadruped Study on Chitosan Microspheres Containing Atorvastatin Calcium: Preparation, Characterization, Quantification And In-Vivo Application
(Pharmaceutical Soc Japan, 2010)
Atorvastatin is commonly used as a cholesterol lowering agent in patients. Recently, the neuroprotective effects of atorvastatin became the focus of many research studies. In this study, we have formulated chitosan ...
Few Drugs Display Flip-Flop Pharmacokinetics And These Are Primarily Associated With Classes 3 And 4 Of The Bddcs
(Wiley, 2015)
This study was conducted to determine the number of drugs exhibiting flip-flop pharmacokinetics following oral (p.o.) dosing from immediate-release dosage forms and if they exhibit a common characteristic that may be ...
Long-Circulating Peg-Pe Micelles Co-Loaded with Paclitaxel and Elacridar (Gg918) Overcome Multidrug Resistance
(Taylor & Francis Ltd, 2012)
Overexpression of drug efflux pump P-gp is one of the major reasons to cause multidrug resistance (MDR). To overcome P-gp mediated MDR, modulators, so called P-gp inhibitors, can be used to block efflux pump activity. ...
Preparation and In Vitro/In Vivo Evaluation of Microparticle Formulations Containing Meloxicam
(Springer, 2012)
In this study, we have formulated chitosan-coated sodium alginate microparticles containing meloxicam (MLX) and aimed to investigate the correlation between in vitro release and in vivo absorbed percentages of meloxicam. ...