Konu "Oncology" için Matematik Bölümü Makale Koleksiyonu listeleme
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Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target
(Amer Assoc Cancer Research, 2007)Protein kinases are central targets for drug-based cancer treatment. To avoid functional impairment, the cell develops mechanisms of drug resistance, primarily based on adaptive mutations. Redesigning a drug to target a ...