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Kardiyovasküler Toksisite Olasılığı Bulunan Bazı İlaçlar Ile Zehirlenmelerin Beyin Natriüretik Peptid Düzeyi Ile Ilişkisi
(Sağlık Bilimleri Enstitüsü, 2014)
Nowadays, referrals to emergency departments due to intoxication
remains to be important in terms of mortality and morbidity. Among these
intoxications, cases with cardiac involvement should be closely monitored. ...
Bazı 2-(4-Sübstitüe)Fenil-5-Benziliden P-Sübstitüebenziliden-3-Fenilaminotiyazolidin-4-On Türevleri Üzerinde Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2014)
In this study, 2 new compunds having 3-
(phenylamino)-2-[4-(1H-1,2,4-triazole/imidazolyl)phenyl]-1,3-thiazolidin-4-one
(Compounds 1,2) and 9 new compounds having 5-(benzylidene/-psubstitutedbenzylidene)-
3-(phenylamin ...
Fetal Sığır Serum Asetilkolinesterazının Tetramerik Yapısını Organize Eden Poliprolin Peptidlerin Kütle Spektrometre ile Analizi
(Sağlık Bilimleri Enstitüsü, 2014)
Acetylcholinesterase (AChE) in the serum of fetal bovine is a tetrameric
enzyme. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans
and horse requires polyproline peptides for assembly into tetramers. ...
Ht29 Ve K562 Kanser Hücrelerinde Protein ve Metabolitlerin Analizi Için Çeşitli Analitik Yöntemlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)
Cancer is one of the most dangerous fatal diseases threating the human being both economically and socially. Therefore, the studies are performed on molecular level to understand cancer on molecular level and prevent the ...
In Vitro/In Vivo Evaluation of Dendrimeric Systems Forretinal Drug Delivery
(Sağlık Bilimleri Enstitüsü, 2014)
Ocular drug delivery is still
a challenge due to its complex structure with many anatomical and physiological
barriers. Delivering drugs to the back of the eye is especially harder because of
barriers like cornea, sclera, ...
Barsaklardan Paraselüler Ilaç Absorpsiyonu Üzerine Permeabilite Artırıcı Ajanların Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)
The aim of this study was to investigate the effect of permeability enhancers on
paracellular drug absorption. For this purpose, acyclovir classified as Class III drug
(high solubility and low permeability) according to ...
Raloksifen'in Biyolojik Materyalden ve Farmasötik Preparattan Analizi İçin Gaz Kromatografisi-Kütle Spektrometrisi Yönteminin Geliştirilmesi ve Valide Edilmesi
(Sağlık Bilimleri Enstitüsü, 2012)
Raloxifene is selective estrogen modulator (SERM) drug which is used in the treatment of postmenopausal osteoporosis in women and used for doping in men. A new gas chromatography-mass spectrometry (GC-MS) method was developed ...
Alzheimer Hastalığı Tedavisinde Kullanılmak Üzere Donepezil Yüklü Plga-B-Peg Nanopartiküllerinin Hazırlanması ve Beyne Hedeflendirilmesi
(Sağlık Bilimleri Enstitüsü, 2015)
Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative
disease, which is caused by irreversible loss of neurons in the hippocampus and
cortex regions of the brain. Although the molecular mechanism ...
Özgün Heterosiklik Bileşiklerin Glutatyon Transferaz P1-1 İnhibitörleri Olarak Araştırılması ve İnsan Meme Kanser Hücreleri Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2012)
The aim of this project is to
design inhibitors for GST P1-1 and test their effectiveness on breast cancer
cells. For this purpose benzoxazole, benzimidazole, benzothiazole derivative
compounds were synthesized. Recombinant ...
Changes in the Vascular Tissue Protein Profile of the Diabetic Rats and the Protective Role of the Beta Blockers
(Sağlık Bilimleri Enstitüsü, 2014)
Cardiovascular complication is the main cause of mortality in diabetes mellitus. Beta blockers are groups of drugs that used in the treatment of heart disease in diabetes mellitus. The object of this study is to investigate ...