Eczacılık Fakültesi
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Yenidoğan Hastalarda İlaç Kaynaklı Sorunlar
(Sağlık Bilimleri Enstitüsü, 2022-11-01)The higher rate of drug-related problems (DRPs) in hospitalized neonates is associated with the diversity of prescribed drugs and differences in age, weight and diagnosis. The aims of this study were (i) to perform risk ... -
Bazı Gentianella Türlerinin Fitokimyasal Analizleri ve Sekonder Metabolitlerinin BDNF (Beyin-Türevli Nörotrofik Faktör) Üzerindeki Etkileri
(Sağlık Bilimleri Enstitüsü, 2022)Gentianella Moench (Gentianaceae) species contain many secondary metabolites such as xanthones, flavonoids and terpenes. Flavonoids have been reported to contribute to the antidepressant effects of many medicinal plants ... -
İmmünokemoterapötik Nanoplekslerin Kolon Kanseri Tedavisinde Etkinlik ve Güvenliliğinin İn Vitro-İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-10-19)Chemotherapy is the most commonly used method after surgery in the treatment of colon cancer. However, cancer cells escape the recognition mechanism of immune system cells in to survive, developing resistance to chemotherapeutics ... -
GLİOBLASTOMANIN GÖRÜNTÜLEME VE FOTODİNAMİK TEDAVİSİ İÇİN MULTİFONKSİYONEL, HEDEFLENDİRİLMİŞ, TERANOSTİK LİPOZOMLARIN GELİŞTİRİLMESİ VE ETKİNLİĞİNİN İN VİTRO İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2022)The desired success in the effective diagnosis and treatment of glioblastoma (GBM), which is one of the types with the highest incidence and lowest survival of brain tumors, has not yet been achieved and studies on effective ... -
Development of Radiopharmaceutical Formulations for Imaging of Non Hodgkin's lymphoma
(Sağlık Bilimleri Enstitüsü, 2022-03-22)Non Hodgkin's Lymphoma (NHL) is the most common subtype of lymphoma, which consists of tumour cells originating from B lymphocyte cells. Burkitt's lymphoma is one of the most common subtypes of NHL, and it is one of the ... -
Serviks Kanser Hücrelerinde Diklofenak Sodyumun Sisplatin Sitotoksisitesi Üzerine Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022-09-16)Avdan, F. Investigation of the Effects of Diclofenac Sodium on Cisplatin Cytotoxicity in Cervical Cancer Cells. Hacettepe University Graduate School of Health Sciences Master Thesis in Pharmaceutical Toxicology, Ankara, ... -
H2 RESEPTÖR ANTAGONİSTLERİNİN YEŞİL HPLC AYIRIMI İÇİN KEMOMETRİK OPTİMİZASYON YAKLAŞIMI VE FAMOTİDİN İÇEREN FARMASÖTİK PREPARATLARA UYGULANMASI
(Sağlık Bilimleri Enstitüsü, 2022)H2 receptor antagonists are often preferred in gastroesophageal reflux disease or in the treatment of gastric acidity disorders. In this thesis, an HPLC method for simultaneous analysis of H2 receptor antagonists, famotidine, ... -
Hipertansiyon Tedavisinde Etkili Çözünürlük Sorunu Olan Bir Etkin Madde Üzerinde Önformülasyon Çalışmaları
(Sağlık Bilimleri Enstitüsü, 2022-09-19)This thesis aims to improve the poor solubility of M3, a molecule that can block both L-type and T-type calcium channels, with nanocrystal technology (NKT), and to develop orally disintegrating film (ADF) formulations ... -
PARASETAMOLÜN PARENTERAL ÇÖZELTİDE STABİLİTE GÖSTERGELİ MİKTAR TAYİNİ İÇİN YÜKSEK PERFORMANSLI SIVI KROMATOGRAFİSİ YÖNTEMİ GELİŞTİRİLMESİ VE VALİDASYONU
(Sağlık Bilimleri Enstitüsü, 2022-09-20)The analytical validation of the parenteral solution in the semi-permeable primary bag and the non-permeable primary vial packaging containing the active ingredient Paracetamol was completed by developing a stability ... -
Kardiyopulmoner Baypas Sonrası Gelişen Akut Böbrek Yetmezliğinin Erken Tanısı İçin Omiks Yaklaşımlar ve Elektroanalitik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2022-09-09)Patients exposed to cardiopulmonary bypass may develop acute renal failure (ARF) as a result of blood coming into contact with the heart-lung machine circuits. The serum creatinine level is checked for the diagnosis of ... -
THE ROLE AND IMPORTANCE OF DORSAL AND VENTRAL HIPPOCAMPAL CATECHOLAMINERGIC INNERVATIONS IN SOCIAL MEMORY OF RATS
(Sağlık Bilimleri Enstitüsü, 2022)This study aims to investigate the role and importance of the catecholaminergic innervations in the dorsal (DH) and ventral hippocampus (VH) in social memory of rats. Female Wistar rats were injected bilaterally with ... -
Somatostatin ve Bazı Analoglarının Miktar Tayini İçin Elektroanalitik Yöntemler Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-02)Ozkan E., Development of Electroanalytical Methods for Quantification of Somatostatin and Some Analogs. Hacettepe University Graduate School of Health Sciences, Analytical Chemistry Program, PhD Thesis, Ankara, 2022. The ... -
DİHİDROPİRİDİN TÜREVLERİNİN SENTEZİ VE L-/T-TİPİ KALSİYUM KANAL BLOKE EDİCİ AKTİVİTELERİ
(Sağlık Bilimleri Enstitüsü, 2022-07-19)1,4- Dihydropyridines (DHPs) are the most well known inhibitors of L-type calcium channels and have important therapeutic value against cardiovascular diseases. Since they target different calcium channel subtypes, they ... -
Glioblastoma Multiforme, Menenjiyom (Birincil) ve Metastaz (İkincil) Beyin Tümörlerine Ait Fenotiplerin Belirlenmesinde Kullanılacak Bütünleşik Omiks Analizler İçin Analitik Yöntem Geliştirilmesi ve Uygulanması
(Sağlık Bilimleri Enstitüsü, 2022)A thorough examination of intermediate molecular levels such as protein, metabolite, and lipid is required to establish direct causal and functional links between genotype and phenotype. Comprehensive metabolomics and ... -
KOLON KANSERİNİN TEDAVİSİNDE FENOTİYAZİN YAPILI BİLEŞİKLERİN KULLANIMLARININ DEĞERLENDİRİLMESİ VE ETKİ MEKANİZMALARININ ARAŞTIRILMASI
(Sağlık Bilimleri Enstitüsü, 2022-07). Epidemiological studies associate cancer and neurodegenerative diseases with each other. Amyloid precursor protein (APP), which is closely related to Alzheimer's disease, attracts attention in cancer research. Recent ... -
Akciğer Kanserine Yönelik siRNA Taşıyıcı Polimerik Nanopartiküllerin Geliştirilmesi ve Etkinliklerinin İn Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022). Lung cancer, one of the most common type of cancers, has the highest mortality rate among all types of cancer, The low effectiveness of current therapies and serious side and toxic effects lead researchers to develop ... -
İmidakloprid ve Asetamipridin İn Vitro Sistemler Üzerindeki Toksik Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-06-27)Neonicotinoids, which have received attention in recent years due to their toxic effects on non-target organisms, particularly bees, are a nicotine-derived insecticide group that is widely used in many countries, including ... -
Böbrek Görüntüleme Amacıyla Kullanılan Teknesyum-99m (Tc-99m) ve Galyum-68 (Ga-68) İşaretli Radyofarmasötiklerin Etkinliklerinin Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2022-03-25)PET and SPECT has an obvious diagnostic advantage over anatomical techniques such as classical BT and MR in determining biochemical changes which mainly occurs before anatomical changes. Most powerful sides of PET are ... -
Sistemik Antifungal İlaç Kullanımının Değerlendirilmesi ve Antifungal Yönetim Ekibi Uygulamaları
(Sağlık Bilimleri Enstitüsü, 2022)Implementation of antifungal stewardship (AFS) program aims to reduce inappropriate use of antifungal drugs. The role of AFS program in the appropriate use of antifungal therapy was evaluated in this study. This study was ... -
Aşılarda Kullanılan Koruyucu ve Adjuvan Maddelerin Olası Toksik Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022)The World Health Organization defines vaccines as “pharmaceutical products that enable our immune system to recognize and fight pathogens such as viruses and bacteria and protect our body against the diseases caused by ...
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