Browsing Temel Eczacılık Bilimleri Bölümü Tez Koleksiyonu by Issue Date
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Raloksifen'in Biyolojik Materyalden ve Farmasötik Preparattan Analizi İçin Gaz Kromatografisi-Kütle Spektrometrisi Yönteminin Geliştirilmesi ve Valide Edilmesi
(Sağlık Bilimleri Enstitüsü, 2012)Raloxifene is selective estrogen modulator (SERM) drug which is used in the treatment of postmenopausal osteoporosis in women and used for doping in men. A new gas chromatography-mass spectrometry (GC-MS) method was developed ... -
Özgün Heterosiklik Bileşiklerin Glutatyon Transferaz P1-1 İnhibitörleri Olarak Araştırılması ve İnsan Meme Kanser Hücreleri Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2012)The aim of this project is to design inhibitors for GST P1-1 and test their effectiveness on breast cancer cells. For this purpose benzoxazole, benzimidazole, benzothiazole derivative compounds were synthesized. Recombinant ... -
Farmasötik Preparatlardan ve Gıdalardan Tobramisin Tayini İçin Moleküler Baskılanmış Nanosensörlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)In this thesis study, the molecularly imprinted glassy carbon and quartz crystal microbalance (QCM) nanosensors were developed for the determination of tobramycin. For QCM nanosensor, firstly the modification of gold surface ... -
Karaciğer ve Meme Kanseri Hücreleri ile Embriyonik Böbrek Hücrelerinde Doksorubisinin Apoptotik Genlerin ve Mdr-1 Geninin Ekspresyon Düzeylerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2013)In this study, in order to investigate roles of certain genes and expression levels of these genes in apoptosis, MCF-7 (breast), HEPG2 (liver) cancer cells and HEK293 embryonic kidney cells were treated with increasing ... -
Development and Validation of an Ultra-Performance Liquid Chromatographic-Tandem Mass Spectrometry (Uplc-Ms/Ms) Method for Determination of Betamethasone or Dexamethasone in Pharmaceutical Preparations
(Sağlık Bilimleri Enstitüsü, 2013)Development and Validation of an Ultra-Performance Liquid Chromatographic-Tandem Mass Spectrometry (UPLC-MS/MS) Method for Determination of Betamethasone or Dexamethasone in Pharmaceutical Preparations, Hacettepe University, ... -
Metastatik Meme Kanseri Hücrelerinde Mtor Üzerine Etkili Bazı Mekanizmaların Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)Signal trunsduction pathways play crucial roles in breast cancer pathogenesis. mTOR, which plays a central role in cell proliferation and interacts with several cell components, is selected as a target in MDA-MB- 231 ... -
Ht29 Ve K562 Kanser Hücrelerinde Protein ve Metabolitlerin Analizi Için Çeşitli Analitik Yöntemlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)Cancer is one of the most dangerous fatal diseases threating the human being both economically and socially. Therefore, the studies are performed on molecular level to understand cancer on molecular level and prevent the ... -
Leflunomid In Farmasötik Preparatlardan Analizi Için Kapiler Elektroforez Yöntemi Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2013)In this study, a new micellar electrokinetic capillary chromatography (MEKC) method was developed to analysis of Leflunomide in pharmaceutical preparations. Best results in the MEKC method were obtained by the use of pH ... -
Lökosit Miyeloperoksidaz Enziminin Saflaştırılması, Kinetik Özellikleri ile Reaktif Türlerin Oluşumundaki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)Myeloperoxidase (MPO) has been purified from human leucocytes obtained by leukapheresis, and kinetic properties were determined, nitrite oxidation and tyrosine nitration catalyzed by the purified enzyme have been studied. ... -
Nnav1.5 Sodyum Kanalı ve Noç-4 Reseptör Sinyalinin Baskılanmasının İnsan Meme Kanseri Hücrelerinde Çoğalma ve Metastatik Potansiye Üzerine Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2013)The incidence of breast cancer is rapidly increasing and it is one of the major causes of death. The molecular changes leading to malignant transformation and metastasis of mammary cells is studied intensively. The expression ... -
İnsan Serum Bütirilkolinesterazı ve Eritrosit Asetilkolinesterazının Statin Türevleri ile Etkileşiminin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2014)To investigate effects of statins on cholinesterases, Butyrylcholinesterase (BChE; E.C.3.1.1.8 ) was purified from human plasma through acid dialysis, DEAE-Tris Acryl M ion exchange and Procainamide-Sepharose 4B chromatography ... -
Fetal Sığır Serum Asetilkolinesterazının Tetramerik Yapısını Organize Eden Poliprolin Peptidlerin Kütle Spektrometre ile Analizi
(Sağlık Bilimleri Enstitüsü, 2014)Acetylcholinesterase (AChE) in the serum of fetal bovine is a tetrameric enzyme. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. ... -
Changes in the Vascular Tissue Protein Profile of the Diabetic Rats and the Protective Role of the Beta Blockers
(Sağlık Bilimleri Enstitüsü, 2014)Cardiovascular complication is the main cause of mortality in diabetes mellitus. Beta blockers are groups of drugs that used in the treatment of heart disease in diabetes mellitus. The object of this study is to investigate ... -
The in Vitro and in Vivo Effects of Telomerase Substrate 6-Thio-2 -Deoxyguanosine
(Sağlık Bilimleri Enstitüsü, 2014)Telomerase mediated telomere targeted therapy represents a new approach in cancer therapy. In this study, I report that the nucleoside analogue 6-thio-2’-deoxyguanosine (6-thio-dG) is recognized by the telomerase ... -
Kimyasal Olarak İndüklenmiş Meme Kanseri Modelinde Klorofilin-Cu Kompleksinin Antioksidan Etkinliğinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2015)Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Investigation show that glutathione and related enzymes are often overexpressed in tumor cells ... -
Serotoninin Renal Hasardaki Rolü
(Sağlık Bilimleri Enstitüsü, 2015)In various acute and chronic renal diseases, tissue damage occurs and platelet activation is observed. Recent studies suggest that some factors released from activated platelets may participate in inflammation and fibrosis ... -
Alzheimer Hastalığı Tedavisinde Kullanılmak Üzere Donepezil Yüklü Plga-B-Peg Nanopartiküllerinin Hazırlanması ve Beyne Hedeflendirilmesi
(Sağlık Bilimleri Enstitüsü, 2015)Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disease, which is caused by irreversible loss of neurons in the hippocampus and cortex regions of the brain. Although the molecular mechanism ... -
Sefuroksim Aksetil' in Voltametrik Davranışlarının İncelenmesi ve Elektroanalitik Yöntemlerle Farmasötik Preparatlardan Analizi
(Sağlık Bilimleri Enstitüsü, 2015)In this thesis, square wave voltammetric (SWV) methods have been developed for the quantitative determination of cefuroxime axetil (CEFA) from pharmaceutical preparations. Electrochemical reduction and oxidation of the ... -
İnsan Serum Bütirilkolinesterazının Karaciğer Hepg2 Hücrelerinde Lipid Metabolizması ile Etkileşiminin İncelenmesi.
(Sağlık Bilimleri Enstitüsü, 2015)Butyrylcholinesterase (BChE) synthesized in liver is mostly associated with the detoxification of xenobiotics. Recently we have shown that in sedentary young males, application of exercise and/or conjugated linoleic acid ... -
Assit Ayırıcı Tanısında Assit Metabolom Tayini için Sıvı Kromatografisi Kütle Spektrometrisi Yöntemi Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2017)Pathological fluid collected in the peritoneal cavity is called ascitic fluid. The concept of the differential diagnosis of ascites is process of diagnosing the disease that causes ascites formation. In this thesis, ...
