Adjuvan Kemoterapi Tedavisi Alan Meme Kanserli Hastalarda Oral Kriyoterapi Uygulamasının Beklentisel, Akut Ve Geç Bulantı Kusmaya Etkisi

Abstract

The purpose of this randomized controlled, statistical blind study that has an intervention control group was to determine the effect of oral cryotherapy on anticipatory, acute, and late nausea and vomiting of breast cancer patients receiving adjuvant chemotherapy. The study was carried out between July 2020-May 2021 in the Unit of the Medical Oncology Department of University of Health Sciences Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital. The study sample consisted of 54 breast cancer patients. 26 patients belonged to the intervention group and 28 to the control group. They were stratified based on their ages and body surface areas and were planned to receive chemotherapy for four cycles. Nausea and vomiting training guide and education was given to all patients in the study to avoid discrimination. The intervention group of the study applied oral cryotherapy with the researcher when they came to the hospital for the treatment and at home. No procedure outside of the routine treatment was performed on patients in the control group. Data in the study were collected through the Patient Information Form, the Rhodes Index of Nausea Vomiting and Retching (RINVR), and the EORTC QLQ-C30 Life Quality Index. The effect of oral cryotherapy was measured by the RINVR by contacting the patients every day for the first week during four cycles. EORTC QLQ-C30 and RINVR were conducted on patients when they came to the hospital throughout their cycles. Following the oral cryotherapy, nausea, vomiting, and retching symptom experience, symptom formation, and symptom distress sub-dimensions of the groups during four cycles were measured and compared. It was seen that the results of the intervention group were significantly lower compared to the control group, and all sub-dimensions of the scale were found to be significantly increasing in the control group (p<0.05). According to the analysis results of the life quality index, second, third and fourth cycle general health average scores of the patients in the intervention group are significantly higher than and functional and symptom score scores were significantly lower than the average scores of the patients in the control group. As a result of this study that oral cryotherapy has a reductive effect on anticipatory, acute, and delayed nausea and vomiting was found to be correct. In this regard, oral cryotherapy is recommended for the management of anticipatory, acute, and late nausea and vomiting in breast cancer patients receiving adjuvant chemotherapy.