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Dinitroanilin Herbisitlerin Neden Olduğu Genotoksik Etkilerin ve Epigenetik Değişikliklerin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2015)
It has been shown that genetic damage has an improtant role in the mechanisms of cancer and other chronic diseases that have been observed all over the world. Recently, theory about that epigenetic changes are also responsible ...
Bazı Yeni 2-Pirazolin Türevlerinin Sentezi ve Monoamin Oksidaz (Mao) İnhibitör Aktiviteleri Üzerinde Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2015)
In this study, forty two compounds which have 1-[2-(5-substituted-2-
benzoxazolinone-3-yl)acetyl]-3,5-disubstitutedphenyl-4,5-dihydro-1H-pyrazole
structure and nine compounds which have N’-(1,3-disubstitutedphenylallyl ...
Kronik Levetirasetam Uygulanan Normal ve Temporal Lob Epilepsi Modeli Oluşturulmuş Sıçanlarda Aromataz Ekspresyonu Değişiklikleri
(Sağlık Bilimleri Enstitüsü, 2015)
Temporal lobe epilepsy (TLE) model was generated at male Wistar rats by intraperitoneal (i.p.) injection of excitotoxic agent kainic acid (KA). This thesis work has been done as to investigate possible side-effects on ...
Kondanse 1,4-Dihidropiridin-3-Karboksilat Türevleri ve Kalsiyum Modülatör Etkileri
(Sağlık Bilimleri Enstitüsü, 2015)
In this study sixteen 2,6,6-trimethyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (compound 1-16) have been synthesized. The synthesis of the compounds was realised by the reaction of the 4,4-dimethyl-1,3-c ...
Astragalus Isauricus Hub.-Mor. & Matthews Üzerinde Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2015)
The genus Astaragalus is represented by 445 species 224 of which are endemic in Turkish flora. Astragalus species have been used to obtain “gum tragacanth” for many years. Also, numerous Astragalus species have been used ...
Hashimoto Tiroiditinde Selenyum ve Selenoprotein Düzeyleri ile Oksidatif Stres Biyogöstergelerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2015)
Hashimoto's thyroiditis (HT) is an autoimmune disease of thyroid gland. In the course of the
disease, thyroid gland is attacked by a variety of cell- and antibody-mediated immune
processes. It is reported that high iodine ...
Perflorooktanoik Asitin Sitotoksisite Ve Oksidatif Stres Indükleyici Etkilerinin In Vivo Ve In Vitro Sistemlerde Araştırılması
(Sağlık Bilimleri Enstitüsü, 2015)
Perfluorooctanoic acid (PFOA)
is a persistent environmental pollutant of toxicological importance. However,
its mechanism of toxicity was not well-characterized. The aim of this study was
to investigate the possible ...