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Anabolic Actions of Parathyroid Hormone during Bone Growth Are Dependent on C-Fos
(Endocrine Soc, 2002)
PTH has anabolic and catabolic actions in bone that are not clearly understood. The protooncogene c-fos and other activating protein 1 family members are critical transcriptional mediators in bone, and c-fos is up-regulated ...
Parathyroid Hormone and Parathyroid Hormone-Related Protein Exert Both Pro- and Anti-Apoptotic Effects In Mesenchymal Cells
(Amer Soc Biochemistry Molecular Biology Inc, 2002)
During bone formation, multipotential mesenchymal cells proliferate and differentiate into osteoblasts, and subsequently many die because of apoptosis. Evidence suggests that the receptor for parathyroid hormone (PTH) and ...