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dc.contributor.authorHanashalshahaby, Essam Hamied Ahmed
dc.contributor.authorUnaleroglu, Canan
dc.contributor.authorCan, Ayse A. K.
dc.contributor.authorOzgun, Alp
dc.contributor.authorGaripcan, Bora
dc.date.accessioned2021-06-09T06:47:11Z
dc.date.available2021-06-09T06:47:11Z
dc.date.issued2019
dc.identifier.issn1300-0527
dc.identifier.urihttp://dx.doi.org/10.3906/kim-1907-71
dc.identifier.urihttp://hdl.handle.net/11655/24867
dc.description.abstractNovel methylene-tethered tetrahydroquinolines (THQs) and cyclopenta[b]pyridines were synthesized by one-pot multicomponent reactions of Mannich bases, enolizable ketones, and NH4 OAc in water by an environmentally friendly K-10 montmorillonite clay-catalyzed reaction. The cytotoxic activities of 1-(2-methyl-8-methylene-5,6,7,8-tetrahydroquinolin-3-yl)ethanone (9a), ethyl 2-methyl-8-methylene-5,6,7,8-tetrahydroquinoline-3 carboxylate (9b), and 1-(2-methyl-7-methylene-6,7-dihydro-5 H-cyclopenta[b]pyridin-3-yl)ethanone (11a) were tested against rat glioblastoma (C6), human breast cancer (MCF-7), prostate cancer (PC3), neuroblastoma (SH-SY5Y), and mouse fibroblast (L929) cell lines in a concentration-dependent (50-300 mu M) and time-dependent (24-72 h) manner and expressed as IC50 values. The results showed that compound 9a induced the lowest IC50 values in all cell lines ranging from 111 +/- 1.1 mu M to 128 +/- 1.3 mu M when compared to 9b and 11a after 72 h. As an evaluation of antibacterial properties, a swarming motility assay was performed with the Pseudomonas aeruginosa PA01 strain and compound 9a showed higher inhibition of swarming motility.
dc.language.isoen
dc.relation.isversionof10.3906/kim-1907-71
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectantitumor activity
dc.subjectgreen synthesis
dc.subjectheteroaromatics
dc.subjectMannich base
dc.subjectmulticomponent reaction
dc.subjectTetrahydroquinolines
dc.titleDesign, Synthesis, And Antitumor Evaluation Of Novel Methylene Moiety-Tethered Tetrahydroquinoline Derivatives
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Chemistry
dc.contributor.departmentKimya
dc.identifier.volume43
dc.identifier.issue6
dc.description.indexWoS
dc.description.indexScopus


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Attribution 4.0 United States
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