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dc.contributor.authorRoubaud-Baudron, Claire
dc.contributor.authorRuiz, Victoria E.
dc.contributor.authorSwan, Alexander M.
dc.contributor.authorVallance, Bruce A.
dc.contributor.authorOzkul, Ceren
dc.contributor.authorPei, Zhiheng
dc.contributor.authorLi, Jackie
dc.contributor.authorBattaglia, Thomas W.
dc.contributor.authorPerez-Perez, Guillermo I.
dc.contributor.authorBlaser, Martin J.
dc.date.accessioned2021-06-03T09:00:40Z
dc.date.available2021-06-03T09:00:40Z
dc.date.issued2019
dc.identifier.issn2150-7511
dc.identifier.urihttp://dx.doi.org/10.1128/mBio.02820-19
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935859/
dc.identifier.urihttp://hdl.handle.net/11655/24377
dc.description.abstractThe gastrointestinal microbiota protects hosts from enteric infections; while antibiotics, by altering the microbiota, may diminish this protection. We show that after early-life exposure to antibiotics host susceptibility to enhanced Citrobacter rodentium-induced colitis is persistent and that this enhanced disease susceptibility is transferable by the antibiotic-altered microbiota. These results strongly suggest that early-life antibiotics have long-term consequences on the gut microbiota and enteropathogen infection susceptibility., Early-life antibiotic exposure may provoke long-lasting microbiota perturbation. Since a healthy gut microbiota confers resistance to enteric pathogens, we hypothesized that early-life antibiotic exposure would worsen the effects of a bacterial infection encountered as an adult. To test this hypothesis, C57BL/6 mice received a 5-day course of tylosin (macrolide), amoxicillin (β-lactam), or neither (control) early in life and were challenged with Citrobacter rodentium up to 80 days thereafter. The early-life antibiotic course led to persistent alterations in the intestinal microbiota and even with pathogen challenge 80 days later worsened the subsequent colitis. Compared to exposure to amoxicillin, exposure to tylosin led to greater disease severity and microbiota perturbation. Transferring the antibiotic-perturbed microbiota to germfree animals led to worsened colitis, indicating that the perturbed microbiota was sufficient for the increased disease susceptibility. These experiments highlight the long-term effects of early-life antibiotic exposure on susceptibility to acquired pathogens.
dc.language.isoen
dc.relation.isversionof10.1128/mBio.02820-19
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleLong-Term Effects Of Early-Life Antibiotic Exposure On Resistance To Subsequent Bacterial Infection
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalMbio
dc.contributor.departmentFarmasötik Mikrobiyoloji
dc.identifier.volume10
dc.identifier.issue6
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus


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Attribution 4.0 United States
Aksi belirtilmediği sürece bu öğenin lisansı: Attribution 4.0 United States