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dc.contributor.authorGuleray, Naz
dc.contributor.authorYucesoy, Halise Meltem
dc.contributor.authorFadiloglu, Erdem
dc.contributor.authorTanacan, Atakan
dc.contributor.authorAlikasifoglu, Mehmet
dc.contributor.authorBeksac, Mehmet Sinan
dc.date.accessioned2021-06-03T05:51:23Z
dc.date.available2021-06-03T05:51:23Z
dc.date.issued2019
dc.identifier.issn0972-3757
dc.identifier.urihttp://dx.doi.org/10.31901/24566330.2019/19.01.713
dc.identifier.urihttp://hdl.handle.net/11655/24159
dc.description.abstractThe researchers evaluated pregnancies in families with balanced/unbalanced translocations. This clinical cohort consisted of 25 pregnancies with balanced/unbalanced chromosomal translocations in family member(s) (maternal, paternal, fetal, abortion material, and/or previous fetus(es)) who underwent prenatal diagnosis. Translocations were observed in 18 cases (14 balanced and 4 unbalanced translocations). The researchers found 2 and 12 cases among the chromosomal translocations were paternal and maternal in origin, respectively. The researchers demonstrated that parent karyotypes were normal in 4 cases, while only maternal karyotypes were normal in 3 cases with unknown paternal karyotypes. Five of the prenatally diagnosed chromosomal abnormalities were Robertsonian and 13 were reciprocal translocations, Among the Robertsonian translocations, 2 were unbalanced. Early fetal loss or recurrent miscarriages were observed in previous history of 10(40%) and 6(24%) respectively. Prenatal diagnosis is critical in pregnancies with balanced/unbalanced chromosomal translocations in a member(s) of the family or those with poor gestational histories.
dc.language.isoen
dc.relation.isversionof10.31901/24566330.2019/19.01.713
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectChorion Villus Sampling
dc.subjectChromosomal Translocation
dc.subjectPregnancy Outcome
dc.subjectPrenatal Diagnosis
dc.titleEvaluation Of Pregnancies In 25 Families With Balanced/Unbalanced Chromosomal Translocations
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalInternational Journal Of Human Genetics
dc.contributor.departmentTıbbi Genetik
dc.identifier.volume19
dc.identifier.issue1
dc.description.indexWoS


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Attribution 4.0 United States
Except where otherwise noted, this item's license is described as Attribution 4.0 United States