dc.contributor.author | Guleray, Naz | |
dc.contributor.author | Yucesoy, Halise Meltem | |
dc.contributor.author | Fadiloglu, Erdem | |
dc.contributor.author | Tanacan, Atakan | |
dc.contributor.author | Alikasifoglu, Mehmet | |
dc.contributor.author | Beksac, Mehmet Sinan | |
dc.date.accessioned | 2021-06-03T05:51:23Z | |
dc.date.available | 2021-06-03T05:51:23Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0972-3757 | |
dc.identifier.uri | http://dx.doi.org/10.31901/24566330.2019/19.01.713 | |
dc.identifier.uri | http://hdl.handle.net/11655/24159 | |
dc.description.abstract | The researchers evaluated pregnancies in families with balanced/unbalanced translocations. This clinical cohort consisted of 25 pregnancies with balanced/unbalanced chromosomal translocations in family member(s) (maternal, paternal, fetal, abortion material, and/or previous fetus(es)) who underwent prenatal diagnosis. Translocations were observed in 18 cases (14 balanced and 4 unbalanced translocations). The researchers found 2 and 12 cases among the chromosomal translocations were paternal and maternal in origin, respectively. The researchers demonstrated that parent karyotypes were normal in 4 cases, while only maternal karyotypes were normal in 3 cases with unknown paternal karyotypes. Five of the prenatally diagnosed chromosomal abnormalities were Robertsonian and 13 were reciprocal translocations, Among the Robertsonian translocations, 2 were unbalanced. Early fetal loss or recurrent miscarriages were observed in previous history of 10(40%) and 6(24%) respectively. Prenatal diagnosis is critical in pregnancies with balanced/unbalanced chromosomal translocations in a member(s) of the family or those with poor gestational histories. | |
dc.language.iso | en | |
dc.relation.isversionof | 10.31901/24566330.2019/19.01.713 | |
dc.rights | Attribution 4.0 United States | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Chorion Villus Sampling | |
dc.subject | Chromosomal Translocation | |
dc.subject | Pregnancy Outcome | |
dc.subject | Prenatal Diagnosis | |
dc.title | Evaluation Of Pregnancies In 25 Families With Balanced/Unbalanced Chromosomal Translocations | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | International Journal Of Human Genetics | |
dc.contributor.department | Tıbbi Genetik | |
dc.identifier.volume | 19 | |
dc.identifier.issue | 1 | |
dc.description.index | WoS | |