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dc.contributor.authorAgache, Ioana
dc.contributor.authorLau, Susanne
dc.contributor.authorAkdis, Cezmi A.
dc.contributor.authorSmolinska, Sylwia
dc.contributor.authorBonini, Matteo
dc.contributor.authorCavkaytar, Ozlem
dc.contributor.authorFlood, Breda
dc.contributor.authorGajdanowicz, Pawe
dc.contributor.authorIzuhara, Kenji
dc.contributor.authorKalayci, Omer
dc.contributor.authorMosges, Ralph
dc.contributor.authorPalomares, Oscar
dc.contributor.authorPapadopoulos, Nikolaos G.
dc.contributor.authorSokolowska, Milena
dc.contributor.authorAngier, Elisabeth
dc.contributor.authorFernandez-Rivas, Montserrat
dc.contributor.authorPajno, Giovanni
dc.contributor.authorPfaar, Oliver
dc.contributor.authorRoberts, Graham C.
dc.contributor.authorRyan, Dermot
dc.contributor.authorSturm, Gunter J.
dc.contributor.authorvan Ree, Ronald
dc.contributor.authorVarga, Eva M.
dc.contributor.authorvan Wijk, Roy Gerth
dc.contributor.authorYepes-Nunez, Juan Jose
dc.contributor.authorJutel, Marek
dc.date.accessioned2021-06-02T10:39:40Z
dc.date.available2021-06-02T10:39:40Z
dc.date.issued2019
dc.identifier.issn0105-4538
dc.identifier.urihttp://dx.doi.org/10.1111/all.13749
dc.identifier.urihttp://hdl.handle.net/11655/23798
dc.description.abstractAllergen immunotherapy (AIT) has been in use for the treatment of allergic disease for more than 100 years. Asthma treatment relies mainly on corticosteroids and other controllers recommended to achieve and maintain asthma control, prevent exacerbations, and improve quality of life. AIT is underused in asthma, both in children and in adults. Notably, patients with allergic asthma not adequately controlled on pharmacotherapy (including biologics) represent an unmet health need. The European Academy of Allergy and Clinical Immunology has developed a clinical practice guideline providing evidence-based recommendations for the use of house dust mites (HDM) AIT as add-on treatment for HDM-driven allergic asthma. This guideline was developed by a multi-disciplinary working group using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. HDM AIT was separately evaluated by route of administration and children and adults: subcutaneous (SCIT) and sublingual AIT (SLIT), drops, and tablets. Recommendations were formulated for each. The important prerequisites for successful treatment with HDM AIT are (a) selection of patients most likely to respond to AIT and (b) use of allergen extracts and desensitization protocols of proven efficacy. To date, only AIT with HDM SLIT-tablet has demonstrated a robust effect in adults for critical end points (exacerbations, asthma control, and safety). Thus, it is recommended as an add-on to regular asthma therapy for adults with controlled or partially controlled HDM-driven allergic asthma (conditional recommendation, moderate-quality evidence). HDM SCIT is recommended for adults and children, and SLIT drops are recommended for children with controlled HDM-driven allergic asthma as the add-on to regular asthma therapy to decrease symptoms and medication needs (conditional recommendation, low-quality evidence).
dc.language.isoen
dc.relation.isversionof10.1111/all.13749
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectallergy
dc.subjectasthma
dc.subjectlung function
dc.subjectallergen immunotherapy
dc.subjectasthma control
dc.subjectasthma exacerbations
dc.subjectGRADE
dc.subjecthouse dust mites
dc.titleEaaci Guidelines On Allergen Immunotherapy: House Dust Mite-Driven Allergic Asthma
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalAllergy
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları
dc.identifier.volume74
dc.identifier.issue5
dc.description.indexWoS
dc.description.indexScopus


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Attribution 4.0 United States
Except where otherwise noted, this item's license is described as Attribution 4.0 United States