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dc.contributor.authorErden, Abdulsamet
dc.contributor.authorFanouriakis, Antonis
dc.contributor.authorKiliç, Levent
dc.contributor.authorSari, Alper
dc.contributor.authorArmağan, Berkan
dc.contributor.authorBilgin, Emre
dc.contributor.authorŞener, Yusuf Ziya
dc.contributor.authorHymabaccus, Benazir
dc.contributor.authorGürler, Fatih
dc.contributor.authorCeylan, Serdar
dc.contributor.authorKiraz, Sedat
dc.contributor.authorKaradağ, Ömer
dc.contributor.authorBoumpas, Dimitrious
dc.date.accessioned2021-03-18T11:19:34Z
dc.date.available2021-03-18T11:19:34Z
dc.date.issued2020-01-09
dc.identifier.citationErden A, Fanouriakis A, Kiliç L, Sari A, Armağan B, Bilgin E, Şener YZ, Hymabaccus B, Gürler F, Ceylan S, Kiraz S, Karadağ Ö, Boumpas D. Geoepidemiology and clinical characteristics of neonatal lupus erythematosus: a systematic literature review of individual patients’ data. Turk J Med Sci. 2020 Jan 9;50(1):281-290. doi: 10.3906/sag-1910-39. PMID: 31905489; PMCID: PMC7164747.tr_TR
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164747/
dc.identifier.urihttps://doi.org/10.3906/sag-1910-39
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/31905489/
dc.identifier.urihttp://hdl.handle.net/11655/23578
dc.description.abstractBackground/aim: Neonatal lupus erythematosus (NLE) is an autoimmune syndrome caused by transplacental transmission of maternal autoantibodies, often with devastating consequences. The objective of this systematic literature review was to analyze the demographic data, geoepidemiology, clinical, and serological characteristics associated with NLE. Materials and methods: We performed a systematic literature search of the Pubmed database covering the period from 1976 to August 2015, using the MeSH terms “neonatal lupus” or “congenital heart block”. To be included in the study, articles of any type (original articles, case series, and case reports) had to report on infants with NLE on an individualized (i.e. patient-by-patient) basis. Results: A total of198 studies were included in the review, reporting on a total of 755 NLE patients. The most frequently reported clinical manifestations of NLE were congenital heart block (CHB, 65.2%), cutaneous lupus (33.1%), and cytopenias (15.5%). We found differences in NLE characteristics based on study geographical origin, with CHB being much more frequent in patients of European or American descent (49.4% and 35%, respectively), while reports originating from Asia reported a higher prevalence of skin involvement (45.2%). Most CHB cases (72.9%) were diagnosed between the 18th and 26th week of gestation. Conclusions: Phenotypic differences of NLE depending on race and country may reflect true pathophysiologic differences or methodologic discrepancies. While maternal autoimmune disease is not a prerequisite for the development of NLE, the existence of a truly “immunonegative” CHB is questionable.tr_TR
dc.language.isoentr_TR
dc.publisherTÜBİTAKtr_TR
dc.relation.isversionof10.3906/sag-1910-39tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectCongenital heart blocktr_TR
dc.subjectGeoepidemiologytr_TR
dc.subjectNeonatal lupustr_TR
dc.subject.lcshTıp uygulamasıtr_TR
dc.titleGeoepidemiology and clinical characteristics of neonatal lupus erythematosus: a systematic literature review of individual patients’ datatr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurk J Med Scitr_TR
dc.contributor.departmentİç Hastalıklarıtr_TR
dc.identifier.volume50tr_TR
dc.identifier.issue1tr_TR
dc.identifier.startpage281tr_TR
dc.identifier.endpage290tr_TR
dc.description.indexPubMedtr_TR
dc.fundingTÜBİTAKtr_TR


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