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dc.contributor.authorPınana, Jose Luis
dc.contributor.authorXhaard, Aliénor
dc.contributor.authorTridello, Gloria
dc.contributor.authorPassweg, Jakob
dc.contributor.authorKozijn, Anne
dc.contributor.authorPolverelli, Nicola
dc.contributor.authorHeras, Inmaculada
dc.contributor.authorPerez, Ariadna
dc.contributor.authorSanz, Jaime
dc.contributor.authorBerghuis, Dagmar
dc.contributor.authorLourdes, Vázquez
dc.contributor.authorSuárez-Lledó, María
dc.contributor.authorItäla-Remes, Maija
dc.contributor.authorOzcelik, Tulay
dc.contributor.authorBasarán, Isabel Iturrate
dc.contributor.authorKarakukcu, Musa
dc.contributor.authorAl Zahrani, Mohsen
dc.contributor.authorChoi, Goda
dc.contributor.authorCuesta Casas, Marián Angeles
dc.contributor.authorMassana, Montserrat Batlle
dc.contributor.authorViviana, Amato
dc.contributor.authorBlijlevens, Nicole
dc.contributor.authorGanser, Arnold
dc.contributor.authorKuskonmaz, Baris
dc.contributor.authorLabussière-Wallet, Hélène
dc.contributor.authorShaw, Peter J
dc.contributor.authorYegin, Zeynep Arzu
dc.contributor.authorGonzález-Vicent, Marta
dc.contributor.authorRocha, Vanderson
dc.contributor.authorFerster, Alina
dc.contributor.authorKnelange, Nina
dc.contributor.authorNavarro, David
dc.contributor.authorMikulska, Malgorzata
dc.contributor.authorde la Camara, Rafael
dc.contributor.authorStyczynski, Jan
dc.date.accessioned2020-10-19T08:20:42Z
dc.date.available2020-10-19T08:20:42Z
dc.date.issued2020
dc.identifier.issn1537-6613
dc.identifier.urihttp://hdl.handle.net/11655/22912
dc.identifier.urihttps://doi.org/10.1093/infdis/jiaa553
dc.description.abstractBackground. Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods. This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3–73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 × 109 /mL, corticosteroid use, and ICU admission (hazard ratios: 10.8, 4.68, and 8.22, respectively; P < .01). Conclusions. Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity
dc.language.isoentr_TR
dc.publisherOxford Univ Presstr_TR
dc.relation.isversionof10.1093/infdis/jiaa553tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSeasonal human coronavirusestr_TR
dc.subjectTransplantationtr_TR
dc.titleSeasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantationtr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalThe Journal of Infectious Diseasestr_TR
dc.contributor.departmentÇocuk Sağlığı ve Hastalıklarıtr_TR
dc.description.indexWoStr_TR
dc.fundingYoktr_TR


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